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AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 56895, updated on 7-Apr-2024

Summary

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Official Symbol
AGPAT4provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:20885
See related
Ensembl:ENSG00000026652 MIM:614795; AllianceGenome:HGNC:20885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAAT4; LPLAT4; 1-AGPAT4; dJ473J16.2; LPAAT-delta
Summary
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
6q26
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (161129967..161274061, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (162488365..162632384, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161550999..161695093, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378093 Neighboring gene uncharacterized LOC102724087 Neighboring gene Sharpr-MPRA regulatory region 6130 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:161396855-161397569 Neighboring gene MPRA-validated peak6299 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:161412339-161413208 Neighboring gene Sharpr-MPRA regulatory region 85 Neighboring gene NANOG hESC enhancer GRCh37_chr6:161422459-161422960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25410 Neighboring gene MPRA-validated peak6300 silencer Neighboring gene MAP3K4 antisense RNA 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:161500530-161501729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25411 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:161549261-161550460 Neighboring gene Sharpr-MPRA regulatory region 15502 Neighboring gene uncharacterized LOC124901455 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:161579309-161579810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161582962-161583462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:161581716-161582274 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:161579811-161580310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161586885-161587594 Neighboring gene NANOG hESC enhancer GRCh37_chr6:161589077-161589672 Neighboring gene Sharpr-MPRA regulatory region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25412 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161606735-161607934 Neighboring gene AGPAT4 intronic transcript 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:161644168-161644410 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:161647413-161647718 Neighboring gene Sharpr-MPRA regulatory region 4197 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:161713123-161713635 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161724387-161725586 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:161736020-161737219 Neighboring gene uncharacterized LOC105378094 Neighboring gene uncharacterized LOC124901457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:161775686-161776186 Neighboring gene parkin RBR E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages. Zhang D, et al. Signal Transduct Target Ther, 2020 Mar 27. PMID 32296017, Free PMC Article
  2. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Bradley RM, et al. Biochim Biophys Acta, 2015 Dec. PMID 26417903
  3. The structure and functions of human lysophosphatidic acid acyltransferases. Leung DW. Front Biosci, 2001 Aug 1. PMID 11487472
  4. Genome-wide association study of co-occurring anxiety in major depression. Schosser A, et al. World J Biol Psychiatry, 2013 Dec. PMID 24047446
  5. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. Lu B, et al. Biochem J, 2005 Jan 15. PMID 15367102, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
    Title: The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of co-occurring anxiety in major depression.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Names
1-AGP acyltransferase 4
1-AGPAT 4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
lysophosphatidic acid acyltransferase delta
lysophosphatidic acid acyltransferase-delta (LPAAT-delta)
lysophospholipid acyltransferase 4
NP_064518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020133.3 → NP_064518.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

    See identical proteins and their annotated locations for NP_064518.1

    Status: REVIEWED

    Source sequence(s)
    AF156776, AL109942, AL122123, BQ072907
    Consensus CDS
    CCDS5280.1
    UniProtKB/Swiss-Prot
    B4DSF9, Q5TEF0, Q9NRZ5
    Related
    ENSP00000314036.4, ENST00000320285.9
    Conserved Domains (3) summary
    cd07990
    Location:62 → 256
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:20 → 345
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:243 → 314
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    161129967..161274061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    162488365..162632384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012733.1: Suppressed sequence

    Description
    NM_001012733.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001012734.1: Suppressed sequence

    Description
    NM_001012734.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRZ5.1 GenPept UniProtKB/Swiss-Prot:Q9NRZ5

Gene LinkOut

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