U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IRGC immunity related GTPase cinema [ Homo sapiens (human) ]

Gene ID: 56269, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
IRGCprovided by HGNC
Official Full Name
immunity related GTPase cinemaprovided by HGNC
Primary source
HGNC:HGNC:28835
See related
Ensembl:ENSG00000124449 MIM:620634; AllianceGenome:HGNC:28835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFGGE; IRGC1; Iigp5; CINEMA; R30953_1
Summary
Predicted to enable GTPase activity. Predicted to be involved in cellular response to interferon-beta and defense response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 28.8) See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43716076..43720021)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46538808..46542768)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44220228..44224173)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene plasminogen activator, urokinase receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10726 Neighboring gene uncharacterized LOC124904724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14732 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44183469-44183968 Neighboring gene phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44204596-44205096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44220201-44220701 Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10729 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44268619-44268844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14739 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44270408-44270571 Neighboring gene CRISPRi-validated cis-regulatory element KCNN4 K1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44281957-44282457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44283513-44284012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10731 Neighboring gene potassium calcium-activated channel subfamily N member 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility. Li J, et al. FEBS Lett, 2023 Jun. PMID 37195149
  2. Human IRGM gene "to be or not to be". Bekpen C, et al. Semin Immunopathol, 2010 Dec. PMID 20737271
  3. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility.
    Title: The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to other organism IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm mitochondrial sheath IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
interferon-inducible GTPase 5
Names
immunity-related GTPase cinema 1
immunity-related GTPase family, cinema 1
interferon-gamma-inducible GTPase IFGGE protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019612.4 → NP_062558.1  interferon-inducible GTPase 5

    See identical proteins and their annotated locations for NP_062558.1

    Status: VALIDATED

    Source sequence(s)
    BC033853, BC066939
    Consensus CDS
    CCDS12629.1
    UniProtKB/Swiss-Prot
    Q05BR8, Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
    Related
    ENSP00000244314.5, ENST00000244314.6
    Conserved Domains (2) summary
    cd04104
    Location:54 → 250
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    cl26332
    Location:12 → 76
    DUF258; Protein of unknown function, DUF258

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43716076..43720021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527118.4 → XP_011525420.1  interferon-inducible GTPase 5 isoform X2

    See identical proteins and their annotated locations for XP_011525420.1

    UniProtKB/Swiss-Prot
    Q05BR8, Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
    Conserved Domains (2) summary
    cd04104
    Location:54 → 250
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    cl26332
    Location:12 → 76
    DUF258; Protein of unknown function, DUF258

  2. XM_005259058.4 → XP_005259115.1  interferon-inducible GTPase 5 isoform X1

    See identical proteins and their annotated locations for XP_005259115.1

    Conserved Domains (3) summary
    cd04104
    Location:91 → 287
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    pfam05049
    Location:59 → 440
    IIGP; Interferon-inducible GTPase (IIGP)
    cl21455
    Location:55 → 113
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006723283.4 → XP_006723346.1  interferon-inducible GTPase 5 isoform X2

    See identical proteins and their annotated locations for XP_006723346.1

    UniProtKB/Swiss-Prot
    Q05BR8, Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
    Conserved Domains (2) summary
    cd04104
    Location:54 → 250
    p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
    cl26332
    Location:12 → 76
    DUF258; Protein of unknown function, DUF258

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46538808..46542768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321467.1 → XP_054177442.1  interferon-inducible GTPase 5 isoform X1

  2. XM_054321469.1 → XP_054177444.1  interferon-inducible GTPase 5 isoform X2

    UniProtKB/Swiss-Prot
    Q05BR8, Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4

  3. XM_054321468.1 → XP_054177443.1  interferon-inducible GTPase 5 isoform X2

    UniProtKB/Swiss-Prot
    Q05BR8, Q6NXR0
    UniProtKB/TrEMBL
    J7NNX4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXR0.1 GenPept UniProtKB/Swiss-Prot:Q6NXR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous