SELENOS selenoprotein S [Homo sapiens (human)] - Gene

Summary

Official Symbol: SELENOSprovided by HGNC
Official Full Name: selenoprotein Sprovided by HGNC
Primary source: HGNC:HGNC:30396
See related: Ensembl:ENSG00000131871 MIM:607918; AllianceGenome:HGNC:30396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015
Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
Expression: Ubiquitous expression in testis (RPKM 27.4), colon (RPKM 26.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q26.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (101270809..101277485, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (99025841..99032517, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (101811014..101817690, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7.
Title: Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7.
Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population.
Title: Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population.
Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3beta/NF-kappaB signaling pathway.
Title: Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway.
The SELS rs34713741 Polymorphism Is Associated with Susceptibility to Colorectal Cancer and Gastric Cancer: A Meta-Analysis.
Title: The SELS rs34713741 Polymorphism Is Associated with Susceptibility to Colorectal Cancer and Gastric Cancer: A Meta-Analysis.
Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis.
Title: Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis.
The levels of SelS and SelK were decreased during adipocyte differentiation and were inversely related to the levels of peroxisome proliferator-activated receptor gamma (PPARgamma), a central regulator of adipogenesis.
Title: Degradation of selenoprotein S and selenoprotein K through PPARγ-mediated ubiquitination is required for adipocyte differentiation.
Selenoprotein S regulates adipogenesis through IRE1alpha-XBP1 pathway.
Title: Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway.
significantly down-regulated in mesangial cells exposed to high glucose or TGF-beta1
Title: High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.
Studied association of selenoprotein S (SEPS1) and selenoprotein P (SEPP1) single nucleotide polymorphisms (SNPs) with expression of SEPS1 and SEPP1 in patients with metabolic syndrome and history of cardiovascular disease.
Title: Effect of single nucleotide polymorphisms in SEPS1 and SEPP1 on expression in the protein level in metabolic syndrome in subjects with cardiovascular disease.
SEPS1 gene polymorphism is associated with diabetic nephropathy.
Title: Correlation between SEPS1 gene polymorphism and type 2 diabetes mellitus: A preliminary study.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH101959 (e-PCR)
- UniSTS:96294

RH46969 (e-PCR)
- UniSTS:6952

SHGC-146438 (e-PCR)
- UniSTS:175216

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables antioxidant activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables ubiquitin-specific protease binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ER overload response	IDA Inferred from Direct Assay more info	PubMed
involved_in ER overload response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell redox homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucose import	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of glycogen biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of inflammatory response	IC Inferred by Curator more info	PubMed
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of macrophage apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nitric-oxide synthase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gluconeogenesis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of nitric oxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to redox state	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde protein transport, ER to cytosol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Derlin-1 retrotranslocation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Derlin-1 retrotranslocation complex	IDA Inferred from Direct Assay more info	PubMed
part_of Derlin-1-VIMP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Derlin-1-VIMP complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
part_of low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of very-low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: selenoprotein S

Names: VCP interacting membrane selenoprotein; VCP-interacting membrane protein; tanis; valosin-containing protein-interacting membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013322.1 RefSeqGene

Range

5011..10305

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_018445.6 → NP_060915.2 selenoprotein S isoform 1

See identical proteins and their annotated locations for NP_060915.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1).

Source sequence(s)

AK097011, BC005840, BG829960

Consensus CDS

CCDS53979.1

UniProtKB/Swiss-Prot

Q3B771, Q9BQE4, Q9P0I6

UniProtKB/TrEMBL

A0A182DWI4

Related

ENSP00000433541.1, ENST00000526049.6

Conserved Domains (1) summary

pfam06936
Location:1 → 187

Selenoprotein_S; Selenoprotein S (SelS)
NM_203472.3 → NP_982298.2 selenoprotein S isoform 2

See identical proteins and their annotated locations for NP_982298.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1, and lacks a selenocysteine (Sec) insertion sequence (SECIS) element in its 3' UTR, which is necessary for the recognition of UGA as a Sec codon. This results in translation termination at the UGA codon and a non-Sec containing shorter isoform (2) compared to isoform 1 (PMID:23614019).

Source sequence(s)

AC023024, BC107774, BG829960, DW430970

UniProtKB/TrEMBL

A0A182DWI4, Q6GYA4

Related

ENSP00000381282.3, ENST00000398226.7

Conserved Domains (1) summary

pfam06936
Location:1 → 187

Selenoprotein_S; Selenoprotein S (SelS)