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EXOC1 exocyst complex component 1 [ Homo sapiens (human) ]

Gene ID: 55763, updated on 5-Mar-2024

Summary

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Official Symbol
EXOC1provided by HGNC
Official Full Name
exocyst complex component 1provided by HGNC
Primary source
HGNC:HGNC:30380
See related
Ensembl:ENSG00000090989 MIM:607879; AllianceGenome:HGNC:30380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC3; SEC3P; BM-102; SEC3L1
Summary
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 10.9), skin (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (55853648..55905086)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59341793..59393237)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56719814..56771252)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377661 Neighboring gene RNA, U6 small nuclear 276, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:56707633-56708266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:56708267-56708900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15445 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:56726227-56727426 Neighboring gene exocyst complex component 1 like Neighboring gene uncharacterized LOC105377663 Neighboring gene RNA, U6 small nuclear 652, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:56786864-56788063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21575 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:56814688-56815652 Neighboring gene uncharacterized LOC124900705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21576 Neighboring gene centrosomal protein 135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:56915160-56915835 Neighboring gene VISTA enhancer hs1651 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56952044-56952696 Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene RNA, 5S ribosomal pseudogene 161

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of rs13117307 single nuclear polymorphism in the risk of uterine cervical cancer from Polish population and its impact on exocyst complex component 1 expression. Łaźniak S, et al. Gene, 2017 Sep 5. PMID 28694212
  2. Anatomic Double-bundle ACL Reconstruction. Schreiber VM, et al. Sports Med Arthrosc Rev, 2010 Mar. PMID 20160627
  3. Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus. Bhuvanakantham R, et al. Cell Microbiol, 2010 Apr 1. PMID 19889084
  4. The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Matern HT, et al. Proc Natl Acad Sci U S A, 2001 Aug 14. PMID 11493706, Free PMC Article
  5. Sec3 knockdown inhibits TGF-β induced epithelial-mesenchymal transition through the down-regulation of Akt phosphorylation in A549 cells. Qian X, et al. Biochem Biophys Res Commun, 2019 Nov 5. PMID 31495494

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study provides evidence that Sec3 is involved in TGF-beta induced cell migration and epithelial-mesenchymal transition processes, presumably through the regulation of PI3K/Akt signaling activation in A549 cancer cells
    Title: Sec3 knockdown inhibits TGF-β induced epithelial-mesenchymal transition through the down-regulation of Akt phosphorylation in A549 cells.
  2. rs13117307 is associated with cervical squamous cell carcinoma. rs13117307 SNP upregulated EXCO1 transcript levels in the non-cancerous cervical and in the cervical SCC tissue.
    Title: Role of rs13117307 single nuclear polymorphism in the risk of uterine cervical cancer from Polish population and its impact on exocyst complex component 1 expression.
  3. This study portrayed the non-structural function of C protein that helped the flavivirus to nullify the antiviral activity of hSec3p by accelerating its degradation and facilitating efficient binding of elongation factor 1alpha with flaviviral RNA genome.
    Title: West Nile virus and dengue virus capsid protein negates the antiviral activity of human Sec3 protein through the proteasome pathway.
  4. This study identified human Sec3 exocyst protein (hSec3p) as a novel interacting partner of West Nile virus and Dengue virus C protein.
    Title: Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus.
  5. Sec3 associates with a subset of Exocyst complexes that are enriched at desmosomes.
    Title: Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells.
  6. The exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation.
    Title: The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef interacts with EXOC1 and this interaction is dependent on the GTPase interaction site of PAK2 PubMed
nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 1 (EXOC1) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10893

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of macroautophagy TAS
Traceable Author Statement
more info
 PubMed 
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 1
Names
SEC3-like 1
exocyst complex component Sec3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024924.2 → NP_001020095.1  exocyst complex component 1 isoform 1

    See identical proteins and their annotated locations for NP_001020095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, as compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC110611, AW589689, BC094751, BM468054
    Consensus CDS
    CCDS3502.1
    UniProtKB/Swiss-Prot
    Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4
    Related
    ENSP00000370695.2, ENST00000381295.7
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 871
    Sec3_C; Exocyst complex component Sec3

  2. NM_018261.4 → NP_060731.2  exocyst complex component 1 isoform 1

    See identical proteins and their annotated locations for NP_060731.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC110611, AK001755, AW589689, BC094751
    Consensus CDS
    CCDS3502.1
    UniProtKB/Swiss-Prot
    Q504V4, Q8WUE7, Q96T15, Q9NV70, Q9NZE4
    Related
    ENSP00000326514.7, ENST00000346134.11
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 871
    Sec3_C; Exocyst complex component Sec3

  3. NM_178237.3 → NP_839955.1  exocyst complex component 1 isoform 2

    See identical proteins and their annotated locations for NP_839955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform 2) lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AC110611, AK027413, AL833208, AW589689, BC094751
    Consensus CDS
    CCDS3503.1
    Related
    ENSP00000334431.6, ENST00000349598.6
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 856
    Sec3_C; Exocyst complex component Sec3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    55853648..55905086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265747.4 → XP_005265804.1  exocyst complex component 1 isoform X1

    See identical proteins and their annotated locations for XP_005265804.1

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 889
    Sec3_C; Exocyst complex component Sec3

  2. XM_017008405.3 → XP_016863894.1  exocyst complex component 1 isoform X2

  3. XM_005265750.4 → XP_005265807.1  exocyst complex component 1 isoform X3

    See identical proteins and their annotated locations for XP_005265807.1

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 856
    Sec3_C; Exocyst complex component Sec3

  4. XM_005265748.2 → XP_005265805.1  exocyst complex component 1 isoform X1

    See identical proteins and their annotated locations for XP_005265805.1

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 889
    Sec3_C; Exocyst complex component Sec3

  5. XM_017008406.2 → XP_016863895.1  exocyst complex component 1 isoform X2

  6. XM_017008407.3 → XP_016863896.1  exocyst complex component 1 isoform X5

  7. XM_047415961.1 → XP_047271917.1  exocyst complex component 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    59341793..59393237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350494.1 → XP_054206469.1  exocyst complex component 1 isoform X1

  2. XM_054350496.1 → XP_054206471.1  exocyst complex component 1 isoform X2

  3. XM_054350498.1 → XP_054206473.1  exocyst complex component 1 isoform X3

  4. XM_054350495.1 → XP_054206470.1  exocyst complex component 1 isoform X1

  5. XM_054350497.1 → XP_054206472.1  exocyst complex component 1 isoform X2

  6. XM_054350500.1 → XP_054206475.1  exocyst complex component 1 isoform X5

  7. XM_054350499.1 → XP_054206474.1  exocyst complex component 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NV70.4 GenPept UniProtKB/Swiss-Prot:Q9NV70

Gene LinkOut

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