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ZNF334 zinc finger protein 334 [ Homo sapiens (human) ]

Gene ID: 55713, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF334provided by HGNC
Official Full Name
zinc finger protein 334provided by HGNC
Primary source
HGNC:HGNC:15806
See related
Ensembl:ENSG00000198185 AllianceGenome:HGNC:15806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in ovary (RPKM 2.5), brain (RPKM 1.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46462313..46513559, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48199760..48249707, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45128269..45142198, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:45034435-45035064 and GRCh37_chr20:45035065-45035694 Neighboring gene uncharacterized LOC105372633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17973 Neighboring gene NANOG hESC enhancer GRCh37_chr20:45052681-45053240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45087277-45087817 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45087818-45088357 Neighboring gene zinc finger protein 663, pseudogene Neighboring gene makorin ring finger protein 7, pseudogene Neighboring gene zinc finger protein 840, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45142238-45142472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45173599-45174450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17976 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45197011-45197512 Neighboring gene solute carrier family 13 member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45211603-45212425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45212426-45213247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:45250755-45251328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45259736-45260484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45260485-45261231 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45302100-45302256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45303169-45303683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45311939-45312450 Neighboring gene TP53 regulating kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth. Yang B, et al. Cell Death Dis, 2023 Mar 25. PMID 36966142, Free PMC Article
  2. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334. Sun D, et al. Cell Death Dis, 2022 May 9. PMID 35534462, Free PMC Article
  3. Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/β-catenin signaling axis. Cheng Z, et al. Cell Mol Life Sci, 2022 May 4. PMID 35507080
  4. Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes. Soroczyńska-Cybula M, et al. Immunology, 2011 Jan. PMID 20738421, Free PMC Article
  5. The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people. Henc I, et al. Acta Biochim Pol, 2015. PMID 25738173

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth.
    Title: Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth.
  2. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334.
    Title: DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334.
  3. Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/beta-catenin signaling axis.
    Title: Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/β-catenin signaling axis.
  4. results obtained in vitro for helper lymphocytes of healthy individuals seem to mimic the regulatory effect of TNFalpha on the expression of ZNF334 in the cells of RA patients
    Title: The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 334

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270497.3 → NP_001257426.1  zinc finger protein 334 isoform c

    See identical proteins and their annotated locations for NP_001257426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK095611, AL034424, AL354745, BC026321
    Consensus CDS
    CCDS74736.1
    UniProtKB/TrEMBL
    A0A087X1P4
    Related
    ENSP00000485779.1, ENST00000625284.2
    Conserved Domains (3) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    COG5048
    Location:318 → 673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001353813.2 → NP_001340742.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745, AL833936, BC026321, DA080528
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001353814.2 → NP_001340743.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001353815.2 → NP_001340744.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001353816.2 → NP_001340745.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001353817.2 → NP_001340746.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001353818.2 → NP_001340747.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001353819.2 → NP_001340748.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001353820.2 → NP_001340749.1  zinc finger protein 334 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    COG5048
    Location:314 → 669
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:234 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:45 → 65
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  10. NM_001353821.2 → NP_001340750.1  zinc finger protein 334 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS74736.1
    UniProtKB/TrEMBL
    A0A087X1P4
    Conserved Domains (3) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    COG5048
    Location:318 → 673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_001353822.2 → NP_001340751.1  zinc finger protein 334 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS74736.1
    UniProtKB/TrEMBL
    A0A087X1P4
    Conserved Domains (3) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    COG5048
    Location:318 → 673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. NM_001353823.2 → NP_001340752.1  zinc finger protein 334 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS74736.1
    UniProtKB/TrEMBL
    A0A087X1P4
    Conserved Domains (3) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    COG5048
    Location:318 → 673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. NM_001353824.2 → NP_001340753.1  zinc finger protein 334 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS33480.1
    UniProtKB/Swiss-Prot
    Q5T6U2, Q9HCZ1, Q9NVW4
    Related
    ENSP00000510334.1, ENST00000692313.1
    Conserved Domains (3) summary
    smart00349
    Location:10 → 70
    KRAB; krueppel associated box
    COG5048
    Location:319 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 259
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. NM_001353825.2 → NP_001340754.1  zinc finger protein 334 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Consensus CDS
    CCDS86959.1
    UniProtKB/TrEMBL
    Q8N3P8
    Related
    ENSP00000473194.1, ENST00000593880.1
    Conserved Domains (3) summary
    COG5048
    Location:342 → 697
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:73 → 93
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  15. NM_001353826.2 → NP_001340755.1  zinc finger protein 334 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745
    Conserved Domains (3) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:326 → 681
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. NM_018102.6 → NP_060572.3  zinc finger protein 334 isoform a

    See identical proteins and their annotated locations for NP_060572.3

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745, BC024177, BC026321
    Consensus CDS
    CCDS33480.1
    UniProtKB/Swiss-Prot
    Q5T6U2, Q9HCZ1, Q9NVW4
    Related
    ENSP00000255129.5, ENST00000347606.8
    Conserved Domains (3) summary
    smart00349
    Location:10 → 70
    KRAB; krueppel associated box
    COG5048
    Location:319 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 259
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. NM_199441.3 → NP_955473.1  zinc finger protein 334 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL034424, AL354745, BC026321
    UniProtKB/TrEMBL
    A0A0B4J1Y0
    Related
    ENSP00000402582.1, ENST00000457685.6
    Conserved Domains (3) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:281 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    46462313..46513559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440281.1 → XP_047296237.1  zinc finger protein 334 isoform X4

    UniProtKB/Swiss-Prot
    Q5T6U2, Q9HCZ1, Q9NVW4

  2. XM_017027937.2 → XP_016883426.1  zinc finger protein 334 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:33 → 93
    KRAB; krueppel associated box
    COG5048
    Location:342 → 697
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262 → 282
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047440282.1 → XP_047296238.1  zinc finger protein 334 isoform X5

    UniProtKB/TrEMBL
    A0A087X1P4
    Related
    ENSP00000484362.1, ENST00000615481.4

  4. XM_047440280.1 → XP_047296236.1  zinc finger protein 334 isoform X2

  5. XM_047440279.1 → XP_047296235.1  zinc finger protein 334 isoform X1

    UniProtKB/TrEMBL
    Q8N3P8

  6. XM_047440284.1 → XP_047296240.1  zinc finger protein 334 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1Y0

  7. XM_047440283.1 → XP_047296239.1  zinc finger protein 334 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1Y0

RNA

  1. XR_007067464.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    48199760..48249707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323668.1 → XP_054179643.1  zinc finger protein 334 isoform X5

    UniProtKB/TrEMBL
    A0A087X1P4

  2. XM_054323667.1 → XP_054179642.1  zinc finger protein 334 isoform X4

    UniProtKB/Swiss-Prot
    Q5T6U2, Q9HCZ1, Q9NVW4

  3. XM_054323666.1 → XP_054179641.1  zinc finger protein 334 isoform X2

  4. XM_054323665.1 → XP_054179640.1  zinc finger protein 334 isoform X1

    UniProtKB/TrEMBL
    Q8N3P8

  5. XM_054323669.1 → XP_054179644.1  zinc finger protein 334 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1Y0

RNA

  1. XR_008485270.1 RNA Sequence

  2. XR_008485272.1 RNA Sequence

  3. XR_008485271.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCZ1.2 GenPept UniProtKB/Swiss-Prot:Q9HCZ1

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