U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PNRC2 proline rich nuclear receptor coactivator 2 [ Homo sapiens (human) ]

Gene ID: 55629, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PNRC2provided by HGNC
Official Full Name
proline rich nuclear receptor coactivator 2provided by HGNC
Primary source
HGNC:HGNC:23158
See related
Ensembl:ENSG00000189266 MIM:611882; AllianceGenome:HGNC:23158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: GeneID 100132235 was merged into this record because the clone on which it was annotated, BX511012.5, was determined to be redundent. [27 May 2009]
Expression
Ubiquitous expression in thyroid (RPKM 68.8), lymph node (RPKM 67.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PNRC2 in Genome Data Viewer
Location:
1p36.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23959164..23963462)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23797250..23800884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24286318..24289952)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 378f Neighboring gene uncharacterized LOC124903877 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:24275932-24276152 Neighboring gene H3 histone pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:24284548-24285176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 386 Neighboring gene serine and arginine rich splicing factor 10 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24306044-24307034 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24307035-24308025 Neighboring gene uncharacterized LOC105378615

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC. Quan J, et al. Biomed Pharmacother, 2019 Feb. PMID 30551118
  2. Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells. Nicholson P, et al. RNA, 2018 Apr. PMID 29348139, Free PMC Article
  3. Structural basis of mRNA-cap recognition by Dcp1-Dcp2. Mugridge JS, et al. Nat Struct Mol Biol, 2016 Nov. PMID 27694842, Free PMC Article
  4. Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. Cho H, et al. Proc Natl Acad Sci U S A, 2015 Mar 31. PMID 25775514, Free PMC Article
  5. Structural basis of the PNRC2-mediated link between mrna surveillance and decapping. Lai T, et al. Structure, 2012 Dec 5. PMID 23085078

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIRN23a is significantly up-regulated in renal cell carcinoma tissues and regulates tumorigenesis by targeting PNRC2 expression.
    Title: MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.
  2. UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay.
    Title: Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.
  3. GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation
    Title: Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.
  4. PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2.
    Title: Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.
  5. PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex.
    Title: Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.
  6. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis.
    Title: Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ20312, MGC99541

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA TAS
Traceable Author Statement
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
proline-rich nuclear receptor coactivator 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017761.4 → NP_060231.1  proline-rich nuclear receptor coactivator 2

    See identical proteins and their annotated locations for NP_060231.1

    Status: VALIDATED

    Source sequence(s)
    AK311305, BC001959, BC078177, DA043474
    Consensus CDS
    CCDS246.1
    UniProtKB/Swiss-Prot
    B4DU72, Q9NPJ4
    Related
    ENSP00000334840.7, ENST00000334351.8
    Conserved Domains (1) summary
    pfam15365
    Location:91 → 137
    PNRC; Proline-rich nuclear receptor coactivator

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23959164..23963462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001691.1 → XP_016857180.1  proline-rich nuclear receptor coactivator 2 isoform X1

    UniProtKB/Swiss-Prot
    B4DU72, Q9NPJ4
    Related
    ENSP00000497590.1, ENST00000647887.1
    Conserved Domains (1) summary
    pfam15365
    Location:91 → 137
    PNRC; Proline-rich nuclear receptor coactivator

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23797250..23800884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPJ4.1 GenPept UniProtKB/Swiss-Prot:Q9NPJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous