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PPP3CC protein phosphatase 3 catalytic subunit gamma [ Homo sapiens (human) ]

Gene ID: 5533, updated on 5-Mar-2024

Summary

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Official Symbol
PPP3CCprovided by HGNC
Official Full Name
protein phosphatase 3 catalytic subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:9316
See related
Ensembl:ENSG00000120910 MIM:114107; AllianceGenome:HGNC:9316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNA3; CALNA3; PP2Bgamma
Summary
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 12.3), lymph node (RPKM 5.3) and 24 other tissues See more
Orthologs
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Genomic context

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See PPP3CC in Genome Data Viewer
Location:
8p21.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22441078..22541125)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22714907..22814982)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22298591..22398638)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22250571-22251133 Neighboring gene ribosomal protein L21 pseudogene 77 Neighboring gene MPRA-validated peak6937 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18986 Neighboring gene RNA, U6 small nuclear 336, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27079 Neighboring gene uncharacterized LOC124901905 Neighboring gene BTF3 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22406579-22407079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22408405-22409369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22409593-22410470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22410471-22411346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22413914-22414436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18990 Neighboring gene Sharpr-MPRA regulatory region 12029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22421349-22422242 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22429393-22430084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22430085-22430775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22431841-22432559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22435755-22436448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22439222-22439914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22442189-22442858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22447071-22448071 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22454615-22455362 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22455363-22456110 Neighboring gene PDZ and LIM domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation. Chen H, et al. J Cell Physiol, 2021 Aug. PMID 33393109
  2. Genetic Variations in the 3'-untranslated Regions of Genes Involved in the Cell Cycle and Apoptosis Pathways Affect Bladder Cancer Risk. Zhang Q, et al. Cancer Genomics Proteomics, 2018 Jan-Feb. PMID 29275364, Free PMC Article
  3. Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury. Osier ND, et al. J Neurotrauma, 2017 Jan 1. PMID 27225880, Free PMC Article
  4. PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway. Fabbri C, et al. Pharmacogenomics J, 2014 Oct. PMID 24709691
  5. Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population. Kinoshita Y, et al. Ann N Y Acad Sci, 2008 Oct. PMID 18991849

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-kappaB pathway by sponging miR-576-5p.
    Title: LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-κB pathway by sponging miR-576-5p.
  2. Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer.
    Title: Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer.
  3. Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation.
    Title: Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation.
  4. PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk.
    Title: Genetic Variations in the 3'-untranslated Regions of Genes Involved in the Cell Cycle and Apoptosis Pathways Affect Bladder Cancer Risk.
  5. These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas.
    Title: Repression of the expression of PPP3CC by ZEB1 confers activation of NF-κB and contributes to invasion and growth in glioma cells.
  6. The rs2443504 AA genotype was associated with the Glasgow coma score at 3, 6, and 12 months following severe brain injury.
    Title: Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.
  7. Knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in hippocampal neurons.
    Title: Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
  8. The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.
    Title: PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway.
  9. protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2+ signaling pathway
    Title: PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation.
  10. study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender
    Title: Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host determinants of HIV-1 control in African Americans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of calcium ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
part_of protein serine/threonine phosphatase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Names
CAM-PRP catalytic subunit
calcineurin, testis-specific catalytic subunit
protein phosphatase 3, catalytic subunit, gamma isozyme
NP_001230903.1
NP_001230904.1
NP_005596.2
XP_047277897.1
XP_047277898.1
XP_054216746.1
XP_054216747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243974.2 → NP_001230903.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 1

    See identical proteins and their annotated locations for NP_001230903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC037459, AK055013, AK299415, AY007249
    Consensus CDS
    CCDS59093.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000380878.3, ENST00000397775.7
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  2. NM_001243975.2 → NP_001230904.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 3

    See identical proteins and their annotated locations for NP_001230904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AK055013, AK299415, AY007249, S46622
    Consensus CDS
    CCDS59094.1
    UniProtKB/Swiss-Prot
    P48454
    Related
    ENSP00000289963.8, ENST00000289963.12
    Conserved Domains (2) summary
    smart00156
    Location:54 → 325
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

  3. NM_005605.5 → NP_005596.2  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2

    See identical proteins and their annotated locations for NP_005596.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK055013, AY007249, BC004864
    Consensus CDS
    CCDS34859.1
    UniProtKB/Swiss-Prot
    B4DRT5, P48454, Q9BSS6, Q9H4M5
    Related
    ENSP00000240139.5, ENST00000240139.10
    Conserved Domains (1) summary
    cd07416
    Location:37 → 341
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22441078..22541125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421941.1 → XP_047277897.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

  2. XM_047421942.1 → XP_047277898.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

RNA

  1. XR_007060744.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22714907..22814982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360771.1 → XP_054216746.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

  2. XM_054360772.1 → XP_054216747.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

RNA

  1. XR_008487862.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48454.3 GenPept UniProtKB/Swiss-Prot:P48454

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
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