AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AGPAT5provided by HGNC
Official Full Name: 1-acylglycerol-3-phosphate O-acyltransferase 5provided by HGNC
Primary source: HGNC:HGNC:20886
See related: Ensembl:ENSG00000155189 MIM:614796; AllianceGenome:HGNC:20886
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPAATE; LPLAT5; 1AGPAT5
Summary: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
Expression: Broad expression in testis (RPKM 16.0), brain (RPKM 13.8) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p23.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (6708642..6761503)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (6464039..6516588)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (6566163..6619024)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5
Title: Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
This publication describes the molecular cloning, tissue distribution, and enzyme characterization of the mouse homolog, mAGPAT5.
Title: Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-14718 (e-PCR)
- UniSTS:829

LPAAT-e__7430 (e-PCR)
- UniSTS:466275

STS-N27164 (e-PCR)
- UniSTS:55927

SHGC-64777 (e-PCR)
- UniSTS:95416

SHGC-143582 (e-PCR)
- UniSTS:171966

RH18525 (e-PCR)
- UniSTS:18143

D8S1511 (e-PCR)
- UniSTS:19699

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	TAS Traceable Author Statement more info
enables acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in acylglycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	TAS Traceable Author Statement more info
involved_in phosphatidylinositol acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Names: 1-AGP acyltransferase 5; 1-AGPAT 5; 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon); lysophosphatidic acid acyltransferase epsilon; lysophospholipid acyltransferase 5; testicular tissue protein Li 144

NP_060831.2

EC 2.3.1.51

XP_047277894.1

EC 2.3.1.51

XP_047277895.1

EC 2.3.1.51

XP_047277896.1

EC 2.3.1.51

XP_054188223.1

EC 2.3.1.51

XP_054188224.1

EC 2.3.1.51

XP_054188225.1

EC 2.3.1.51

XP_054216743.1

EC 2.3.1.51

XP_054216744.1

EC 2.3.1.51

XP_054216745.1

EC 2.3.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018361.5 → NP_060831.2 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

See identical proteins and their annotated locations for NP_060831.2

Status: REVIEWED

Source sequence(s)

AF287957

Consensus CDS

CCDS34796.1

UniProtKB/Swiss-Prot

Q8IZ47, Q9BQG4, Q9NUQ2

UniProtKB/TrEMBL

A0A024R640, Q6NUM7

Related

ENSP00000285518.6, ENST00000285518.11

Conserved Domains (3) summary

cd07990
Location:63 → 263

LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

COG0204
Location:34 → 281

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

pfam16076
Location:258 → 318

Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

6708642..6761503

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421939.1 → XP_047277895.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1
XM_047421938.1 → XP_047277894.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1
XM_047421940.1 → XP_047277896.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2

Reference GRCh38.p14 PATCHES

Genomic

NW_018654717.1 Reference GRCh38.p14 PATCHES

Range

103912..156773

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332249.1 → XP_054188224.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1
XM_054332248.1 → XP_054188223.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1
XM_054332250.1 → XP_054188225.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

6464039..6516588

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054360769.1 → XP_054216744.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1
XM_054360768.1 → XP_054216743.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1
XM_054360770.1 → XP_054216745.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2