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RNF121 ring finger protein 121 [ Homo sapiens (human) ]

Gene ID: 55298, updated on 3-Apr-2024

Summary

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Official Symbol
RNF121provided by HGNC
Official Full Name
ring finger protein 121provided by HGNC
Primary source
HGNC:HGNC:21070
See related
Ensembl:ENSG00000137522 MIM:620529; AllianceGenome:HGNC:21070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in kidney (RPKM 7.3), thyroid (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71929046..71997597)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71855935..71924512)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71640092..71708643)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 128 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71660091-71661028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71661029-71661964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5175 Neighboring gene uncharacterized LOC100128494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71725991-71726738 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:71728895-71730094 Neighboring gene interleukin 18 binding protein Neighboring gene nuclear mitotic apparatus protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Really interesting new gene finger protein 121 is a tumor suppressor of renal cell carcinoma. Xiang P, et al. Gene, 2018 Nov 15. PMID 30149063
  2. RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2. Maghsoudlou A, et al. Traffic, 2016 Mar. PMID 26602861, Free PMC Article
  3. Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis. Zhao Y, et al. Acta Biochim Biophys Sin (Shanghai), 2014 Aug. PMID 24928685
  4. Structure of human glycosylphosphatidylinositol transamidase. Zhang H, et al. Nat Struct Mol Biol, 2022 Mar. PMID 35165458
  5. Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer. Choi Y, et al. Br J Cancer, 2018 Jul. PMID 29955133, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we identified and characterised oncogenic fusion genes and their function in CRC, and implicated NAGLU-IKZF3 and RNF121-FOLR2 as novel molecular targets for personalised medicine development.
    Title: Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.
  2. Study found that RNF121 was less expressed in tumor tissues than adjacent normal tissues of renal cell carcinoma (RCC) patients. Overexpression of RNF121 inhibited the growth of human RCC cells in vivo. Moreover, RNF121 impeded the proliferation, migration and invasion of human RCC cells in vitro. In addition, RNF121 was found to activate NF-kappaB signaling pathway via promoting IkappaBalpha degradation in RCC cells.
    Title: Really interesting new gene finger protein 121 is a tumor suppressor of renal cell carcinoma.
  3. Over-expression of RNF121 promoted ubiquitination of VEGFR-2, inhibited its maturation . RNF121 knockdown in primary endothelial cells reduced VEGFR-2 ubiquitination and increased its cell surface level.
    Title: RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2.
  4. These results unveil an unexpected role of Golgi Apparatus and reveal RNF121 as a new player involved in the signaling leading to NF-kappaB activation.
    Title: The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation.
  5. This is the first study to demonstrate that RNF121 is a novel regulator of apoptosis and provides a new potential target for cancer therapy
    Title: Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11099

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin ligase RNF121
NP_001287855.1
NP_060790.2
XP_006718692.1
XP_006718695.1
XP_047283189.1
XP_047283190.1
XP_054225266.1
XP_054225267.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300926.2 → NP_001287855.1  E3 ubiquitin ligase RNF121 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has shorter and distinct N- and C-termini compared to isoform a.
    Source sequence(s)
    AL833638, AP002490, DA209781
    Consensus CDS
    CCDS73343.1
    UniProtKB/TrEMBL
    C9JQY5
    Related
    ENSP00000377316.3, ENST00000393713.7

  2. NM_018320.5 → NP_060790.2  E3 ubiquitin ligase RNF121 isoform a

    See identical proteins and their annotated locations for NP_060790.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
    Consensus CDS
    CCDS8203.1
    UniProtKB/Swiss-Prot
    B3KSW8, Q6IA57, Q6P449, Q96DB4, Q9H920
    UniProtKB/TrEMBL
    A0PJP0
    Related
    ENSP00000354571.3, ENST00000361756.8
    Conserved Domains (1) summary
    cd16475
    Location:224 → 278
    RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

RNA

  1. NR_024147.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. If translation initiates at the same codon as used in variant 1, then this results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). Although a putative alternate AUG site is observed in a different frame downstream of the standard AUG site, it is not likely to be used because it is located within the short ORF available with the standard AUG site (as defined by variant 1). Therefore, the transcript is represented as a non-protein-coding RefSeq.
    Source sequence(s)
    AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
    Related
    ENST00000530137.1

  2. NR_024148.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing an internal coding exon and also includes an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). There are no other likely translation initiation sites and so the transcript is represented as a non-protein-coding RefSeq.
    Source sequence(s)
    AI291325, AK023139, AK094508, AL833638, AP002490, CN392009, DA209781, DA694800
    Related
    ENST00000526549.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    71929046..71997597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718629.2 → XP_006718692.1  E3 ubiquitin ligase RNF121 isoform X1

    See identical proteins and their annotated locations for XP_006718692.1

    UniProtKB/TrEMBL
    A0PJP0
    Conserved Domains (1) summary
    pfam13639
    Location:190 → 240
    zf-RING_2; Ring finger domain

  2. XM_006718632.2 → XP_006718695.1  E3 ubiquitin ligase RNF121 isoform X4

    See identical proteins and their annotated locations for XP_006718695.1

    Conserved Domains (1) summary
    pfam13639
    Location:119 → 169
    zf-RING_2; Ring finger domain

  3. XM_047427233.1 → XP_047283189.1  E3 ubiquitin ligase RNF121 isoform X2

  4. XM_047427234.1 → XP_047283190.1  E3 ubiquitin ligase RNF121 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    71855935..71924512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369292.1 → XP_054225267.1  E3 ubiquitin ligase RNF121 isoform X4

  2. XM_054369291.1 → XP_054225266.1  E3 ubiquitin ligase RNF121 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194452.1: Suppressed sequence

    Description
    NM_194452.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).

  2. NM_194453.1: Suppressed sequence

    Description
    NM_194453.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H920.1 GenPept UniProtKB/Swiss-Prot:Q9H920

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