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PPP6R3 protein phosphatase 6 regulatory subunit 3 [ Homo sapiens (human) ]

Gene ID: 55291, updated on 5-Mar-2024

Summary

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Official Symbol
PPP6R3provided by HGNC
Official Full Name
protein phosphatase 6 regulatory subunit 3provided by HGNC
Primary source
HGNC:HGNC:1173
See related
Ensembl:ENSG00000110075 MIM:610879; AllianceGenome:HGNC:1173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAPL; PP6R3; SAPLa; SAPS3; SAP190; C11orf23
Summary
Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in thyroid (RPKM 14.0), testis (RPKM 11.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q13.2
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68460752..68615334)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68465656..68620220)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68228220..68382802)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68080045-68080920 Neighboring gene uncharacterized LOC124900302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68080921-68081795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68082507-68083006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68084075-68084742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68095823-68096400 Neighboring gene uncharacterized LOC124902698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68099859-68100434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68110204-68111055 Neighboring gene LDL receptor related protein 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68120602-68121235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68121869-68122501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68141212-68141935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5136 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68154179-68154402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68164501-68165000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3671 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68185667-68186590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68213843-68214446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68214447-68215051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68215052-68215655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68237400-68237900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278329-68278907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278908-68279485 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68307752-68308457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68310718-68311218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68311219-68311719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68351250-68351750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68370649-68370853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68376961-68377462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68377463-68377962 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68390073-68390603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:68399697-68400286 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400287-68400875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400876-68401464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68419596-68420268 Neighboring gene uncharacterized LOC107984343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68450731-68451406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68452083-68452758 Neighboring gene Sharpr-MPRA regulatory region 1260 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68462220-68462721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68474187-68474945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68479758-68480258 Neighboring gene galanin and GMAP prepropeptide Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68518115-68519100 Neighboring gene testis expressed metallothionein like protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis. Guo R, et al. Genes Chromosomes Cancer, 2016 Aug. PMID 27113271
  2. Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase. Heo J, et al. Biochem J, 2020 Jan 31. PMID 31904830
  3. Involvement of DPP9 in gene fusions in serous ovarian carcinoma. Smebye ML, et al. BMC Cancer, 2017 Sep 11. PMID 28893231, Free PMC Article
  4. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. Twells RC, et al. Genomics, 2001 Mar 15. PMID 11401438
  5. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Douglas P, et al. Mol Cell Biol, 2010 Mar. PMID 20065038, Free PMC Article

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The substitution of Ala in nine putative phosphorylation sites in SAPS3 was required to prevent CK2 activation of the phosphatase. Different CK2 chemical inhibitors equally increased phosphorylation of endogenous AURKA in living cells, consistent with reduction in PP6 activity.
    Title: Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase.
  2. Results from a study on gene expression variability markers in early-stage human embryos shows that PPP6R3 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
    Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
  3. we found a DPP9-PPP6R3 fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 corresponding to the breakpoints identified by RNA-seq.
    Title: Involvement of DPP9 in gene fusions in serous ovarian carcinoma.
  4. Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of Nodular fasciitis
    Title: PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 6, regulatory subunit 3 (PPP6R3; C11orf23) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712, DKFZp781E2374, DKFZp781O2362, DKFZp781E17107

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 6 regulatory subunit 3
Names
SAPS domain family, member 3
sporulation-induced transcript 4-associated protein SAPL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164160.2 → NP_001157632.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

    See identical proteins and their annotated locations for NP_001157632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1. The resulting isoform (4) lacks two internal segments, compared to isoform 1. Variants 4, 24, and 39 all encode the same isoform (4).
    Source sequence(s)
    AB046778, BC007738, BP314824
    Consensus CDS
    CCDS53671.1
    UniProtKB/Swiss-Prot
    Q5H9R7
    Related
    ENSP00000377390.3, ENST00000393801.7
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  2. NM_001164161.2 → NP_001157633.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6

    See identical proteins and their annotated locations for NP_001157633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an additional exon in the 5' UTR, lacks three alternate in-frame exons, and uses an alternate splice site resulting in a distinct 3' coding region, compared to variant 1. The resulting isoform (6) lacks three internal segments and has a distinct C-terminus, compared to isoform 1. Variants 6, 28, and 35 all encode the same isoform (6).
    Source sequence(s)
    AB046778, BC007738, BP314824, CR933658
    Consensus CDS
    CCDS53672.1
    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
    Related
    ENSP00000377389.2, ENST00000393800.7
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  3. NM_001164162.2 → NP_001157634.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001157634.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 8, encodes isoform 1.
    Source sequence(s)
    BC007738, BC105933, BP314824, CR749815
    Consensus CDS
    CCDS53673.1
    UniProtKB/Swiss-Prot
    Q5H9R7
    Related
    ENSP00000433058.1, ENST00000524904.5
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  4. NM_001164163.2 → NP_001157635.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_001157635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the C-terminus, compared to isoform 1. Variants 2 and 23 both encode the same isoform (2).
    Source sequence(s)
    AK315136, BC007738, BC107599
    Consensus CDS
    CCDS53674.1
    UniProtKB/Swiss-Prot
    Q5H9R7
    Related
    ENSP00000431415.1, ENST00000524845.5
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  5. NM_001164164.2 → NP_001157636.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001157636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AF264780, BC007738, DB207620
    Consensus CDS
    CCDS53675.1
    UniProtKB/Swiss-Prot
    Q5H9R7
    Related
    ENSP00000437329.1, ENST00000529710.5
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 462
    SAPS; SIT4 phosphatase-associated protein

  6. NM_001352347.2 → NP_001339276.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    H0YEN2
    Conserved Domains (1) summary
    pfam04499
    Location:1 → 288
    SAPS; SIT4 phosphatase-associated protein

  7. NM_001352348.2 → NP_001339277.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS53673.1
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  8. NM_001352350.2 → NP_001339279.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 36 and 40, encodes isoform 8.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  9. NM_001352351.2 → NP_001339280.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  10. NM_001352352.2 → NP_001339281.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 31, encodes isoform 10.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  11. NM_001352353.2 → NP_001339282.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    H0YEN2
    Conserved Domains (1) summary
    pfam04499
    Location:1 → 351
    SAPS; SIT4 phosphatase-associated protein

  12. NM_001352354.2 → NP_001339283.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 16, encodes isoform 12.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  13. NM_001352355.2 → NP_001339284.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  14. NM_001352356.2 → NP_001339285.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 14, encodes isoform 12.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  15. NM_001352357.2 → NP_001339286.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    H0YEN2
    Related
    ENSP00000436209.1, ENST00000534190.5
    Conserved Domains (1) summary
    pfam04499
    Location:1 → 288
    SAPS; SIT4 phosphatase-associated protein

  16. NM_001352358.2 → NP_001339287.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 462
    SAPS; SIT4 phosphatase-associated protein

  17. NM_001352359.2 → NP_001339288.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  18. NM_001352360.2 → NP_001339289.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 33, encodes isoform 17.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  19. NM_001352361.2 → NP_001339290.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Related
    ENSP00000434429.1, ENST00000534534.5
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  20. NM_001352362.2 → NP_001339291.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variant 25, encodes isoform 19.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  21. NM_001352363.2 → NP_001339292.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS53674.1
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  22. NM_001352364.2 → NP_001339293.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variants 4 and 39, encodes isoform 4.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS53671.1
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  23. NM_001352365.2 → NP_001339294.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variant 22, encodes isoform 19.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  24. NM_001352366.2 → NP_001339295.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  25. NM_001352368.2 → NP_001339297.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variants 6 and 35, encodes isoform 6.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS53672.1
    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  26. NM_001352369.2 → NP_001339298.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    H0YEN2
    Conserved Domains (1) summary
    pfam04499
    Location:1 → 288
    SAPS; SIT4 phosphatase-associated protein

  27. NM_001352370.2 → NP_001339299.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  28. NM_001352371.2 → NP_001339300.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31), as well as variant 12, encodes isoform 10.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  29. NM_001352372.2 → NP_001339301.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32), as well as variant 37, encodes isoform 24.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  30. NM_001352373.2 → NP_001339302.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33), as well as variant 20, encodes isoform 17.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  31. NM_001352374.2 → NP_001339303.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34), as well as variant 38, encodes isoform 22.
    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  32. NM_001352375.2 → NP_001339304.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35), as well as variants 6 and 28, encodes isoform 6.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS53672.1
    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  33. NM_001352376.2 → NP_001339305.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (36), as well as variants 10 and 40, encodes isoform 8.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  34. NM_001352377.2 → NP_001339306.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24

    Status: VALIDATED

    Description
    Transcript Variant: This variant (37), as well as variant 32, encodes isoform 24.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  35. NM_001352378.2 → NP_001339307.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (38), as well as variant 34, encodes isoform 22.
    Source sequence(s)
    AP000807, AP001788, AP003096
    UniProtKB/TrEMBL
    E9PQP7
    Conserved Domains (1) summary
    pfam04499
    Location:37 → 422
    SAPS; SIT4 phosphatase-associated protein

  36. NM_001352379.2 → NP_001339308.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (39), as well as variants 4 and 24, encodes isoform 4.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS53671.1
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  37. NM_001352380.2 → NP_001339309.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (40), as well as variants 10 and 36, encodes isoform 8.
    Source sequence(s)
    AP000807, AP001788, AP003096
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  38. NM_001411030.1 → NP_001397959.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096
    Consensus CDS
    CCDS91521.1
    UniProtKB/TrEMBL
    E9PKF6

  39. NM_018312.5 → NP_060782.2  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 5

    See identical proteins and their annotated locations for NP_060782.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an additional exon in the 5' UTR and lacks three alternate in-frame exons in the coding region, compared to variant 1. The resulting isoform (5) lacks three internal segments, compared to isoform 1.
    Source sequence(s)
    AF264779, BC007738, DB207620
    Consensus CDS
    CCDS8182.1
    Related
    ENSP00000265636.4, ENST00000265636.9
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 462
    SAPS; SIT4 phosphatase-associated protein

RNA

  1. NR_147965.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

  2. NR_147966.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

  3. NR_147967.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

  4. NR_147968.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

  5. NR_147969.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

  6. NR_147970.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

  7. NR_147971.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000807, AP001788, AP003096

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    68460752..68615334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427204.1 → XP_047283160.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

  2. XM_047427206.1 → XP_047283162.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  3. XM_047427212.1 → XP_047283168.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  4. XM_006718608.4 → XP_006718671.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  5. XM_006718612.4 → XP_006718675.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  6. XM_006718614.3 → XP_006718677.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

    See identical proteins and their annotated locations for XP_006718677.1

    UniProtKB/Swiss-Prot
    Q5H9R7
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  7. XM_047427209.1 → XP_047283165.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

  8. XM_017017969.2 → XP_016873458.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  9. XM_047427215.1 → XP_047283171.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  10. XM_047427219.1 → XP_047283175.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

    UniProtKB/TrEMBL
    E9PKF6

  11. XM_006718621.3 → XP_006718684.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    H7BXH2
    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  12. XM_047427225.1 → XP_047283181.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

  13. XM_047427228.1 → XP_047283184.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

  14. XM_024448601.2 → XP_024304369.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X13

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 462
    SAPS; SIT4 phosphatase-associated protein

  15. XM_006718624.3 → XP_006718687.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X15

    See identical proteins and their annotated locations for XP_006718687.1

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 462
    SAPS; SIT4 phosphatase-associated protein

  16. XM_047427205.1 → XP_047283161.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

  17. XM_047427207.1 → XP_047283163.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  18. XM_047427213.1 → XP_047283169.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  19. XM_047427208.1 → XP_047283164.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  20. XM_047427211.1 → XP_047283167.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  21. XM_047427216.1 → XP_047283172.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  22. XM_047427218.1 → XP_047283174.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

  23. XM_047427223.1 → XP_047283179.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    H7BXH2

  24. XM_047427227.1 → XP_047283183.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

  25. XM_047427229.1 → XP_047283185.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

  26. XM_006718623.4 → XP_006718686.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X14

    See identical proteins and their annotated locations for XP_006718686.1

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 462
    SAPS; SIT4 phosphatase-associated protein

  27. XM_047427214.1 → XP_047283170.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  28. XM_047427202.1 → XP_047283158.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

  29. XM_047427203.1 → XP_047283159.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

  30. XM_047427210.1 → XP_047283166.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

  31. XM_047427217.1 → XP_047283173.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  32. XM_047427221.1 → XP_047283177.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

    UniProtKB/TrEMBL
    E9PKF6
    Related
    ENSP00000433565.1, ENST00000527403.6

  33. XM_047427224.1 → XP_047283180.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    H7BXH2
    Related
    ENSP00000265637.4, ENST00000265637.8

  34. XM_047427226.1 → XP_047283182.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

  35. XM_047427230.1 → XP_047283186.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

  36. XM_006718627.4 → XP_006718690.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

    Conserved Domains (1) summary
    pfam04499
    Location:128 → 513
    SAPS; SIT4 phosphatase-associated protein

  37. XM_047427232.1 → XP_047283188.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

  38. XM_047427231.1 → XP_047283187.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    68465656..68620220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369257.1 → XP_054225232.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

  2. XM_054369260.1 → XP_054225235.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  3. XM_054369266.1 → XP_054225241.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  4. XM_054369253.1 → XP_054225228.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

  5. XM_054369255.1 → XP_054225230.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

  6. XM_054369259.1 → XP_054225234.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  7. XM_054369263.1 → XP_054225238.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

  8. XM_054369269.1 → XP_054225244.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  9. XM_054369270.1 → XP_054225245.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  10. XM_054369274.1 → XP_054225249.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

    UniProtKB/TrEMBL
    E9PKF6

  11. XM_054369276.1 → XP_054225251.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    H7BXH2

  12. XM_054369279.1 → XP_054225254.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

  13. XM_054369282.1 → XP_054225257.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

  14. XM_054369285.1 → XP_054225260.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X13

  15. XM_054369287.1 → XP_054225262.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X15

  16. XM_054369258.1 → XP_054225233.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3

    UniProtKB/Swiss-Prot
    Q3B7I1, Q3I4Y0, Q3KR35, Q5H9R7, Q68CR3, Q7L4R8, Q8N3B2, Q96MB2, Q9H2K5, Q9H2K6, Q9HCL4, Q9NUY3

  17. XM_054369261.1 → XP_054225236.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  18. XM_054369267.1 → XP_054225242.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  19. XM_054369262.1 → XP_054225237.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X4

  20. XM_054369265.1 → XP_054225240.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  21. XM_054369271.1 → XP_054225246.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  22. XM_054369273.1 → XP_054225248.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X8

  23. XM_054369277.1 → XP_054225252.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    H7BXH2

  24. XM_054369281.1 → XP_054225256.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

  25. XM_054369283.1 → XP_054225258.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

  26. XM_054369286.1 → XP_054225261.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X14

  27. XM_054369268.1 → XP_054225243.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X6

  28. XM_054369254.1 → XP_054225229.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1

  29. XM_054369256.1 → XP_054225231.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2

  30. XM_054369264.1 → XP_054225239.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X5

  31. XM_054369272.1 → XP_054225247.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X7

  32. XM_054369275.1 → XP_054225250.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X9

    UniProtKB/TrEMBL
    E9PKF6

  33. XM_054369278.1 → XP_054225253.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X10

    UniProtKB/TrEMBL
    H7BXH2

  34. XM_054369280.1 → XP_054225255.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X11

  35. XM_054369284.1 → XP_054225259.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X12

  36. XM_054369288.1 → XP_054225263.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

  37. XM_054369290.1 → XP_054225265.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

  38. XM_054369289.1 → XP_054225264.1  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X16

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5H9R7.2 GenPept UniProtKB/Swiss-Prot:Q5H9R7

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