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PPP2R2C protein phosphatase 2 regulatory subunit Bgamma [ Homo sapiens (human) ]

Gene ID: 5522, updated on 5-Mar-2024

Summary

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Official Symbol
PPP2R2Cprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Bgammaprovided by HGNC
Primary source
HGNC:HGNC:9306
See related
Ensembl:ENSG00000074211 MIM:605997; AllianceGenome:HGNC:9306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR52; PR55G; IMYPNO; IMYPNO1; B55gamma; B55-GAMMA
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 39.0), endometrium (RPKM 11.7) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
4p16.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (6320581..6563799, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (6294675..6540171, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6322308..6565526, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21258 Neighboring gene JAKMIP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6247680-6248310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6264593-6265371 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:6266160-6267359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6274585-6275134 Neighboring gene VISTA enhancer hs1979 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6333689-6334190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6340800-6341378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6341379-6341956 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:6368797-6369537 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:6369538-6370278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6371026-6371745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6378434-6379114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6390823-6391322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6392177-6392889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6395469-6396022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6394915-6395468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6445131-6445630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6464699-6465244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6465245-6465790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6471820-6472650 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6528063-6528950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6528951-6529838 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6529839-6530726 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6530727-6531613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6551456-6551956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6551957-6552457 Neighboring gene uncharacterized LOC105374365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6575112-6575880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6575881-6576648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6576649-6577417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6595035-6595534 Neighboring gene Sharpr-MPRA regulatory region 2687 Neighboring gene mannosidase alpha class 2B member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:6624177-6624370

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PP2A Regulatory Subunit B55γ is a Gatekeeper of Osteoblast Maturation and Lineage Maintenance. Serguienko A, et al. Stem Cells Dev, 2017 Oct 1. PMID 28805158
  2. PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality. Bluemn EG, et al. Mol Cancer Res, 2013 Jun. PMID 23493267, Free PMC Article
  3. PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD. Jacob C, et al. Atten Defic Hyperact Disord, 2012 Sep. PMID 22664926
  4. PPP2R2C, a gene disrupted in autosomal dominant intellectual disability. Backx L, et al. Eur J Med Genet, 2010 Sep-Oct. PMID 20601260
  5. Identification of specific PP2A complexes involved in human cell transformation. Chen W, et al. Cancer Cell, 2004 Feb. PMID 14998489

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increase susceptibility to increased insulin resistance by 50% and its risk may be exacerbated by consuming more than 10 cups coffee/week or 220 mg caffeine/day.
    Title: High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.
  2. B55gamma is induced by glucocorticoid receptor in human primary BM-MSCs during differentiation to osteoblast and is required for osteoblast morphogenesis.
    Title: PP2A Regulatory Subunit B55γ is a Gatekeeper of Osteoblast Maturation and Lineage Maintenance.
  3. miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C.
    Title: miR-1301 promotes prostate cancer proliferation through directly targeting PPP2R2C.
  4. These findings provide insights into mechanisms by which prostate cancers resist AR-pathway suppression and support inhibiting PPP2R2C complexes.
    Title: PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality.
  5. PPP2R2C is a potential tumor suppressor gene in human brain cancers.
    Title: Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.
  6. evidence suggests that allelic variation in PPP2R2C may be associated with a variety of personality traits and ADHD per se.
    Title: PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD.
  7. encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity
    Title: PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
  10. novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma
    Title: A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33570

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 2, regulatory subunit B, gamma
Names
phosphoprotein phosphatase 2A BR gamma regulatory chain
protein phosphatase 2A1 B gamma subunit
NP_001193923.1
NP_001193924.1
NP_001193925.1
NP_001350317.1
NP_065149.2
NP_870991.1
XP_011511798.1
XP_047271847.1
XP_047271848.1
XP_054206357.1
XP_054206358.1
XP_054206359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029233.1 RefSeqGene

    Range
    95987..248020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206994.2 → NP_001193923.1  protein phosphatase 2, regulatory subunit B, gamma isoform c

    See identical proteins and their annotated locations for NP_001193923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AC093323, AC116317, AK296474, BC045682
    Consensus CDS
    CCDS56305.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000423649.1, ENST00000506140.5
    Conserved Domains (2) summary
    COG5170
    Location:17 → 431
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:20 → 68
    7WD40; WD40 repeat [structural motif]

  2. NM_001206995.2 → NP_001193924.1  protein phosphatase 2, regulatory subunit B, gamma isoform c

    See identical proteins and their annotated locations for NP_001193924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AC116317, AK316003, BC045682, DC327075
    Consensus CDS
    CCDS56305.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000425247.1, ENST00000507294.1
    Conserved Domains (2) summary
    COG5170
    Location:17 → 431
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:20 → 68
    7WD40; WD40 repeat [structural motif]

  3. NM_001206996.2 → NP_001193925.1  protein phosphatase 2, regulatory subunit B, gamma isoform d

    See identical proteins and their annotated locations for NP_001193925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC116317, BC032954, BC045682
    Consensus CDS
    CCDS56304.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000422374.1, ENST00000515571.5
    Conserved Domains (2) summary
    COG5170
    Location:7 → 421
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:10 → 58
    7WD40; WD40 repeat [structural motif]

  4. NM_001363388.2 → NP_001350317.1  protein phosphatase 2, regulatory subunit B, gamma isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' splice site and is predicted to use an alternate start codon, compared to variant 1. This variant encodes a protein (isoform e) with a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC114815, AC116317
    Conserved Domains (2) summary
    COG5170
    Location:8 → 424
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:13 → 61
    7WD40; WD40 repeat [structural motif]

  5. NM_020416.4 → NP_065149.2  protein phosphatase 2, regulatory subunit B, gamma isoform a

    See identical proteins and their annotated locations for NP_065149.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC114815, AC116317, AK093115, BM551976
    Consensus CDS
    CCDS3387.1
    UniProtKB/Swiss-Prot
    A8MSY7, B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7, Q9Y2T4
    Related
    ENSP00000372042.4, ENST00000382599.9
    Conserved Domains (2) summary
    COG5170
    Location:21 → 438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 75
    7WD40; WD40 repeat [structural motif]

  6. NM_181876.3 → NP_870991.1  protein phosphatase 2, regulatory subunit B, gamma isoform b

    See identical proteins and their annotated locations for NP_870991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is the same length as isoform a.
    Source sequence(s)
    AC116317, AK093115
    Consensus CDS
    CCDS3388.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000335083.5, ENST00000335585.9
    Conserved Domains (2) summary
    COG5170
    Location:22 → 438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 75
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    6320581..6563799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415891.1 → XP_047271847.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

  2. XM_047415892.1 → XP_047271848.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

  3. XM_011513496.2 → XP_011511798.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

    See identical proteins and their annotated locations for XP_011511798.1

    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 56
    7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    6294675..6540171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350383.1 → XP_054206358.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

  2. XM_054350384.1 → XP_054206359.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

  3. XM_054350382.1 → XP_054206357.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2T4.4 GenPept UniProtKB/Swiss-Prot:Q9Y2T4

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