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PPP1R10 protein phosphatase 1 regulatory subunit 10 [ Homo sapiens (human) ]

Gene ID: 5514, updated on 7-Apr-2024

Summary

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Official Symbol
PPP1R10provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 10provided by HGNC
Primary source
HGNC:HGNC:9284
See related
Ensembl:ENSG00000204569 MIM:603771; AllianceGenome:HGNC:9284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p99; FB19; R111; CAT53; PNUTS; PP1R10
Summary
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in thyroid (RPKM 17.1), adrenal (RPKM 16.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30600413..30617243, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30464593..30482813, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30568190..30585020, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30524110-30524674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30524675-30525239 Neighboring gene proline rich 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30538839-30539400 Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:30577096-30578295 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30585278-30585846 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene Sharpr-MPRA regulatory region 13793 Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer. Marx A, et al. Dis Markers, 2020. PMID 32377272, Free PMC Article
  2. Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression. Wang F, et al. Mol Cancer Res, 2019 Jan. PMID 30190438
  3. MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability. Dingar D, et al. Nat Commun, 2018 Aug 29. PMID 30158517, Free PMC Article
  4. A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Grelet S, et al. Nat Cell Biol, 2017 Sep. PMID 28825698, Free PMC Article
  5. Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold. Zacharchenko T, et al. Protein J, 2016 Oct. PMID 27591855

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT via regulating ZEB1 expression.
    Title: Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT via regulating ZEB1 expression.
  2. Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer.
    Title: Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer.
  3. Poly(A) site-dependent deceleration caused by PNUTS-PP1 and Spt5 dephosphorylation is required to convert Pol II into a viable target for the Xrn2 terminator exonuclease, leading to transcription termination.
    Title: Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.
  4. PNUTS depletion suppresses the activation of Aurora A/B kinases, and disrupts the spatiotemporal regulation of the chromosomal passenger complex (CPC). PNUTS dynamically localizes to kinetochores, and is required for the activation of the spindle assembly checkpoint.
    Title: Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression.
  5. The work demonstrates that PP1/PNUTS stabilizes chromatin-bound MYC in proliferating cells.
    Title: MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.
  6. A -31 G to A "hot zone" putative functional noncoding variant of PPP1R10 was found in an AML patient. It perturbs the binding activities of E2F1, E2F4, ZBTB33, and TBP. SRSF1 and PPP1R10 genes are interacting partners in a protein-protein interaction network.
    Title: Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients.
  7. PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context.
    Title: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.
  8. Biophysical analysis of PNUTS suggests an extended transcription factor TFIIS-like fold.
    Title: Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold.
  9. PNUTS was a valid target of miR-383 and was involved in the inhibition of gammaH2AX.
    Title: microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells.
  10. PNUTS inhibits the PP1-mediated dephosphorylation of critical substrates, especially retinoblastoma protein, by blocking their binding sites on PP1.
    Title: Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV transcription is restricted by the dissociation of a functional P-TEFb complex (CCNT1-CDK9) caused by PPP1R10 (PNUTS) PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Depletion of protein phosphatase 1, regulatory subunit 10 (PPP1R10) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed
capsid gag CA expression increases whilst endogeneous PPP1R10 (PNUTS) expression decreases in HIV-1 (NL4-3) infected MOLT-3 cells over time PubMed
gag MIR34A (miR-34A)-mediated increase in CA expression is inversely proportional to PPP1R10 (PNUTS) expression in HEK 293T cells co-transfected with pNL4-3, MIR34A and Myc-PNUTS PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 1 binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitotic DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 1 regulatory subunit 10
Names
HLA-C associated transcript 53
MHC class I region proline-rich protein CAT53
PP1-binding protein of 114 kDa
phosphatase 1 nuclear targeting subunit
protein phosphatase 1, regulatory (inhibitor) subunit 10
testis tissue sperm-binding protein Li 67n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376195.1 → NP_001363124.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 both encode the same protein.
    Source sequence(s)
    AL662800
    Consensus CDS
    CCDS4681.1
    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0
    Conserved Domains (3) summary
    TIGR01385
    Location:102 → 215
    TFSII; transcription elongation factor S-II
    pfam18044
    Location:910 → 932
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. NM_002714.4 → NP_002705.2  serine/threonine-protein phosphatase 1 regulatory subunit 10

    See identical proteins and their annotated locations for NP_002705.2

    Status: REVIEWED

    Source sequence(s)
    AJ544537, BC150310
    Consensus CDS
    CCDS4681.1
    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0
    Related
    ENSP00000365694.2, ENST00000376511.7
    Conserved Domains (3) summary
    TIGR01385
    Location:102 → 215
    TFSII; transcription elongation factor S-II
    pfam18044
    Location:910 → 932
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RNA

  1. NR_072994.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL662800

  2. NR_164780.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL662800

  3. NR_164781.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL662800

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30600413..30617243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514722.2 → XP_011513024.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    See identical proteins and their annotated locations for XP_011513024.1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0
    Conserved Domains (3) summary
    TIGR01385
    Location:102 → 215
    TFSII; transcription elongation factor S-II
    pfam18044
    Location:910 → 932
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2080137..2098356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329833.1 → XP_054185808.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054329834.1 → XP_054185809.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1856243..1874462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330317.1 → XP_054186292.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054330318.1 → XP_054186293.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1910642..1928854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330614.1 → XP_054186589.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054330615.1 → XP_054186590.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    1944460..1962680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330834.1 → XP_054186809.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054330835.1 → XP_054186810.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1855502..1873720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331094.1 → XP_054187069.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054331095.1 → XP_054187070.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    1901171..1919390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331365.1 → XP_054187340.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054331366.1 → XP_054187341.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30464593..30482813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355770.1 → XP_054211745.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0

  2. XM_054355771.1 → XP_054211746.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O00405, Q96QC0
    UniProtKB/TrEMBL
    A0A1U9X8C5, Q2L6I0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QC0.1 GenPept UniProtKB/Swiss-Prot:Q96QC0

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