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CPVL carboxypeptidase vitellogenic like [ Homo sapiens (human) ]

Gene ID: 54504, updated on 3-Apr-2024

Summary

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Official Symbol
CPVLprovided by HGNC
Official Full Name
carboxypeptidase vitellogenic likeprovided by HGNC
Primary source
HGNC:HGNC:14399
See related
Ensembl:ENSG00000106066 MIM:609780; AllianceGenome:HGNC:14399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HVLP
Summary
The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. [provided by RefSeq, Jan 2017]
Expression
Broad expression in spleen (RPKM 87.7), thyroid (RPKM 67.4) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7p14.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (28994636..29195451, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29132164..29333261, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29034252..29235067, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28682874-28683374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28683375-28683875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:28725036-28725544 Neighboring gene ribosomal protein S2 pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25799 Neighboring gene NANOG hESC enhancer GRCh37_chr7:28808272-28808863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:28832834-28833543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25800 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:28877832-28878523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18047 Neighboring gene Sharpr-MPRA regulatory region 6215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29025827-29026326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29061318-29062086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29062087-29062854 Neighboring gene CPVL antisense RNA 2 Neighboring gene TLR4 interactor with leucine rich repeats Neighboring gene uncharacterized LOC128966558 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:29165822-29167021 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:29178298-29179497 Neighboring gene CPVL antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29235044-29235679 Neighboring gene CHN2 antisense RNA 1 Neighboring gene chimerin 2 Neighboring gene Nanog homeobox pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages. Mahoney JA, et al. Genomics, 2001 Mar 15. PMID 11401439
  2. Selective accumulation of related CD4+ T cell clones in the synovial fluid of patients with rheumatoid arthritis. Striebich CC, et al. J Immunol, 1998 Oct 15. PMID 9780222
  3. CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients. Hu C, et al. Diabetes, 2011 Nov. PMID 21911749, Free PMC Article
  4. Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire. Ignatovich O, et al. J Mol Biol, 1999 Nov 26. PMID 10610771
  5. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Maeda S, et al. Diabetes, 2010 Aug. PMID 20460425, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CPVL suppresses metastasis of nasopharyngeal carcinoma through inhibiting epithelial-mesenchymal transition.
    Title: CPVL suppresses metastasis of nasopharyngeal carcinoma through inhibiting epithelial-mesenchymal transition.
  2. genetic association studies in a Chinese population with type 2 diabetes: An SNP in CPVL (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
    Title: CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog
Genome-wide association study of atypical psychosis.
EBI GWAS Catalog
Genome-wide association with diabetes-related traits in the Framingham Heart Study.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of vitellogenic-like carboxypeptidase (CPVL) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
probable serine carboxypeptidase CPVL
Names
CP-Mac carboxypeptidase
VCP-like protein
carboxypeptidase WUG
vitellogenic carboxypeptidase-like protein
NP_001334981.1
NP_001334983.1
NP_001358184.1
NP_001358185.1
NP_001358186.1
NP_001358187.1
NP_001358189.1
NP_001358190.1
NP_001358191.1
NP_001358192.1
NP_001358193.1
NP_001358194.1
NP_001358195.1
NP_001358196.1
NP_001358197.1
NP_061902.2
NP_112601.3
XP_011513739.1
XP_016867855.1
XP_047276486.1
XP_047276487.1
XP_054214475.1
XP_054214476.1
XP_054214477.1
XP_054214478.1
XP_054214479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348052.1 → NP_001334981.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  2. NM_001348054.1 → NP_001334983.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  3. NM_001371255.1 → NP_001358184.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  4. NM_001371256.1 → NP_001358185.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  5. NM_001371257.1 → NP_001358186.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  6. NM_001371258.1 → NP_001358187.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  7. NM_001371260.1 → NP_001358189.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Related
    ENSP00000387164.1, ENST00000409850.5
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  8. NM_001371261.1 → NP_001358190.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  9. NM_001371262.1 → NP_001358191.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  10. NM_001371263.1 → NP_001358192.1  probable serine carboxypeptidase CPVL isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  11. NM_001371264.1 → NP_001358193.1  probable serine carboxypeptidase CPVL isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) encodes the longest isoform (a).
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    UniProtKB/TrEMBL
    B3KW79

  12. NM_001371265.1 → NP_001358194.1  probable serine carboxypeptidase CPVL isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 15 and 16, encodes isoform c.
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    UniProtKB/TrEMBL
    B3KW79

  13. NM_001371266.1 → NP_001358195.1  probable serine carboxypeptidase CPVL isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform c.
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    UniProtKB/TrEMBL
    B3KW79

  14. NM_001371267.1 → NP_001358196.1  probable serine carboxypeptidase CPVL isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 14 and 15, encodes isoform c.
    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096
    UniProtKB/TrEMBL
    B3KW79

  15. NM_001371268.1 → NP_001358197.1  probable serine carboxypeptidase CPVL isoform d

    Status: REVIEWED

    Source sequence(s)
    AC004593, AC005162, AC005232, AC007096

  16. NM_019029.3 → NP_061902.2  probable serine carboxypeptidase CPVL isoform b precursor

    See identical proteins and their annotated locations for NP_061902.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC005162, AK075433, BC016838
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Related
    ENSP00000379572.3, ENST00000396276.7
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  17. NM_031311.5 → NP_112601.3  probable serine carboxypeptidase CPVL isoform b precursor

    See identical proteins and their annotated locations for NP_112601.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1-12 all encode the same isoform (b).
    Source sequence(s)
    AC005162, AK075433
    Consensus CDS
    CCDS5419.1
    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Related
    ENSP00000265394.5, ENST00000265394.10
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    28994636..29195451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012366.2 → XP_016867855.1  probable serine carboxypeptidase CPVL isoform X2

    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    cl08270
    Location:69 → 377
    Peptidase_S10; Serine carboxypeptidase

  2. XM_047420531.1 → XP_047276487.1  probable serine carboxypeptidase CPVL isoform X2

  3. XM_011515437.2 → XP_011513739.1  probable serine carboxypeptidase CPVL isoform X1

    See identical proteins and their annotated locations for XP_011513739.1

    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41
    UniProtKB/TrEMBL
    B3KW79
    Conserved Domains (1) summary
    pfam00450
    Location:69 → 466
    Peptidase_S10; Serine carboxypeptidase

  4. XM_047420530.1 → XP_047276486.1  probable serine carboxypeptidase CPVL isoform X1

    UniProtKB/Swiss-Prot
    A4D1A4, Q6UX20, Q8NBL7, Q96AR7, Q9H3G5, Q9HB41

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    29132164..29333261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358500.1 → XP_054214475.1  probable serine carboxypeptidase CPVL isoform X1

  2. XM_054358501.1 → XP_054214476.1  probable serine carboxypeptidase CPVL isoform X1

  3. XM_054358503.1 → XP_054214478.1  probable serine carboxypeptidase CPVL isoform X2

  4. XM_054358504.1 → XP_054214479.1  probable serine carboxypeptidase CPVL isoform X2

  5. XM_054358502.1 → XP_054214477.1  probable serine carboxypeptidase CPVL isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H3G5.2 GenPept UniProtKB/Swiss-Prot:Q9H3G5

Gene LinkOut

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