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PLA2G5 phospholipase A2 group V [ Homo sapiens (human) ]

Gene ID: 5322, updated on 3-Apr-2024

Summary

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Official Symbol
PLA2G5provided by HGNC
Official Full Name
phospholipase A2 group Vprovided by HGNC
Primary source
HGNC:HGNC:9038
See related
Ensembl:ENSG00000127472 MIM:601192; AllianceGenome:HGNC:9038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRFB; GV-PLA2; PLA2-10; hVPLA(2)
Summary
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues See more
Orthologs
all
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Genomic context

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Location:
1p36.13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20028408..20091911)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19852033..19915547)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20396687..20418404)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20304755-20305254 Neighboring gene RNA, 7SL, cytoplasmic 304, pseudogene Neighboring gene phospholipase A2 group IIA Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1574 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:20316184-20316758 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:20316759-20317334 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1580 Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1609 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1624 Neighboring gene Sharpr-MPRA regulatory region 6877 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1646 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 312 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1658 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1659 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1661 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1663 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 313 Neighboring gene phospholipase A2 group IID Neighboring gene ATAC-STARR-seq lymphoblastoid active region 314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20468424-20468924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20474795-20475295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20476004-20476630 Neighboring gene phospholipase A2 group IIF

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Epigenetic control of group V phospholipase A2 expression in human malignant cells. Menschikowski M, et al. Tumour Biol, 2016 Jun. PMID 26715269
  2. Phospholipase A2 group v in benign familial fleck retina in a set of triplets. Bin NJ, et al. Retina, 2015 Jun. PMID 25549071
  3. The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study. Vargas-Alarcón G, et al. Biomed Res Int, 2014. PMID 24959594, Free PMC Article
  4. Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. Holmes MV, et al. Circ Cardiovasc Genet, 2014 Apr. PMID 24563418, Free PMC Article
  5. Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina. Sergouniotis PI, et al. Am J Hum Genet, 2011 Dec 9. PMID 22137173, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A2.
    Title: Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).
  2. Lysosome-mediated autophagy pathway contributes to gVPLA2 clearance from lung endothelial cells.
    Title: Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.
  3. This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
    Title: Hydrolysis of Phosphatidylcholine-Isoprostanes (PtdCho-IP) by Peripheral Human Group IIA, V and X Secretory Phospholipases A(2) (sPLA(2)).
  4. Low GV-PLA2 expression is associated with cancer.
    Title: Epigenetic control of group V phospholipase A2 expression in human malignant cells.
  5. Data show that phospholipase A2 group IIA, V and X have different target/function related activity.
    Title: Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X.
  6. The clinical findings in this family suggest a diagnosis of benign familial fleck retina with excellent prognosis, in which the PLA2G5 gene may play a role.
    Title: Phospholipase A2 group v in benign familial fleck retina in a set of triplets.
  7. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation.
    Title: Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo.
  8. results demonstrate that EPCR is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2
    Title: Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.
  9. expression of PLA2s-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
    Title: The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.
  10. Summarizing, Der p1 and Fel d1 involve phospholipase A2 enzymes in their action.
    Title: The step further to understand the role of cytosolic phospholipase A2 alpha and group X secretory phospholipase A2 in allergic inflammation: pilot study.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Familial benign flecked retina
MedGen: C1856718 OMIM: 228980 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46205, DKFZp686C2294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in low-density lipoprotein particle remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of antifungal innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of immune complex clearance by monocytes and macrophages IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of opsonization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in phagolysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase A2 group V
Names
Ca2+-dependent phospholipase A2
calcium-dependent phospholipase A2
phosphatidylcholine 2-acylhydrolase 5
NP_000920.1
XP_005245948.1
XP_005245949.1
XP_005245950.1
XP_011539888.1
XP_011539889.1
XP_011539890.1
XP_011539891.1
XP_011539892.1
XP_011539893.1
XP_011539894.1
XP_047278564.1
XP_047278572.1
XP_047278591.1
XP_047278593.1
XP_047278599.1
XP_047278601.1
XP_054193058.1
XP_054193059.1
XP_054193060.1
XP_054193061.1
XP_054193062.1
XP_054193063.1
XP_054193064.1
XP_054193065.1
XP_054193066.1
XP_054193067.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032045.1 RefSeqGene

    Range
    4987..26704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000929.3 → NP_000920.1  phospholipase A2 group V precursor

    See identical proteins and their annotated locations for NP_000920.1

    Status: REVIEWED

    Source sequence(s)
    AL158172, AV709457, BC036792, BM684907, BM705479
    Consensus CDS
    CCDS202.1
    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Related
    ENSP00000364249.3, ENST00000375108.4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    20028408..20091911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422608.1 → XP_047278564.1  phospholipase A2 group V isoform X1

  2. XM_047422616.1 → XP_047278572.1  phospholipase A2 group V isoform X1

  3. XM_047422645.1 → XP_047278601.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  4. XM_005245891.6 → XP_005245948.1  phospholipase A2 group V isoform X1

    See identical proteins and their annotated locations for XP_005245948.1

    Conserved Domains (1) summary
    cd00125
    Location:52 → 168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  5. XM_047422635.1 → XP_047278591.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  6. XM_011541589.4 → XP_011539891.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_011539891.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  7. XM_047422637.1 → XP_047278593.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  8. XM_011541587.4 → XP_011539889.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_011539889.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  9. XM_011541588.4 → XP_011539890.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_011539890.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  10. XM_005245893.6 → XP_005245950.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_005245950.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  11. XM_011541590.4 → XP_011539892.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_011539892.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  12. XM_005245892.6 → XP_005245949.1  phospholipase A2 group V isoform X1

    See identical proteins and their annotated locations for XP_005245949.1

    Conserved Domains (1) summary
    cd00125
    Location:52 → 168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  13. XM_047422643.1 → XP_047278599.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  14. XM_011541591.4 → XP_011539893.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_011539893.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  15. XM_011541586.4 → XP_011539888.1  phospholipase A2 group V isoform X1

    See identical proteins and their annotated locations for XP_011539888.1

    Conserved Domains (1) summary
    cd00125
    Location:52 → 168
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

  16. XM_011541592.4 → XP_011539894.1  phospholipase A2 group V isoform X2

    See identical proteins and their annotated locations for XP_011539894.1

    UniProtKB/Swiss-Prot
    P39877, Q8N435
    UniProtKB/TrEMBL
    B3KUQ4
    Conserved Domains (1) summary
    cd00125
    Location:21 → 137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19852033..19915547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337089.1 → XP_054193064.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  2. XM_054337087.1 → XP_054193062.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  3. XM_054337088.1 → XP_054193063.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  4. XM_054337090.1 → XP_054193065.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  5. XM_054337091.1 → XP_054193066.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  6. XM_054337092.1 → XP_054193067.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435

  7. XM_054337084.1 → XP_054193059.1  phospholipase A2 group V isoform X1

  8. XM_054337083.1 → XP_054193058.1  phospholipase A2 group V isoform X1

  9. XM_054337085.1 → XP_054193060.1  phospholipase A2 group V isoform X1

  10. XM_054337086.1 → XP_054193061.1  phospholipase A2 group V isoform X2

    UniProtKB/Swiss-Prot
    P39877, Q8N435
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39877.1 GenPept UniProtKB/Swiss-Prot:P39877

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