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PHB1 prohibitin 1 [ Homo sapiens (human) ]

Gene ID: 5245, updated on 7-Apr-2024

Summary

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Official Symbol
PHB1provided by HGNC
Official Full Name
prohibitin 1provided by HGNC
Primary source
HGNC:HGNC:8912
See related
Ensembl:ENSG00000167085 MIM:176705; AllianceGenome:HGNC:8912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHB; HEL-215; HEL-S-54e
Summary
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in kidney (RPKM 68.3), colon (RPKM 44.2) and 25 other tissues See more
Orthologs
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Genomic context

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See PHB1 in Genome Data Viewer
Location:
17q21.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49404052..49414882, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50267083..50277908, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47481414..47492244, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8668 Neighboring gene ZNF652 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12361 Neighboring gene eukaryotic translation initiation factor 4E pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12362 Neighboring gene long intergenic non-protein coding RNA 2075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis. Mao J, et al. Mol Hum Reprod, 2022 May 27. PMID 35639746
  2. Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance. Huang H, et al. Nat Commun, 2021 Jun 17. PMID 34140524, Free PMC Article
  3. Prohibitin regulates mTOR pathway via interaction with FKBP8. Zhang J, et al. Front Med, 2021 Jun. PMID 33259040
  4. Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility. Li XH, et al. Asian J Androl, 2020 Nov-Dec. PMID 32859869, Free PMC Article
  5. Prohibitin 1/2 mediates Dengue-3 entry into human neuroblastoma (SH-SY5Y) and microglia (CHME-3) cells. Sharma A, et al. J Biomed Sci, 2020 Apr 19. PMID 32306962, Free PMC Article

See all (410) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids.
    Title: Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids.
  2. Hepatic prohibitin 1 and methionine adenosyltransferase alpha1 defend against primary and secondary liver cancer metastasis.
    Title: Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis.
  3. Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells.
    Title: Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells.
  4. The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor.
    Title: The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor.
  5. XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.
    Title: XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.
  6. Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis.
    Title: Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis.
  7. Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
    Title: Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
  8. Prohibitin regulates mTOR pathway via interaction with FKBP8.
    Title: Prohibitin regulates mTOR pathway via interaction with FKBP8.
  9. Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance.
    Title: Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance.
  10. Role of Oxidative Stress in Prognosis of Ovarian Cancer.
    Title: Role of Oxidative Stress in Prognosis of Ovarian Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (145)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env HIV-1 gp120 upregulates the expression of prohibitin in umbilical cord blood mononuclear cells and T-cell lines PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with prohibitin 1 (PHB1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env The C-terminal cytoplasmic domain (Env-CT) of HIV-1 Env specifically binds to the Phb1/Phb2 complex. Strong binding is dependent on Env residues 790-800. L799R/L800Q double mutation in Env severely inhibits its binding to the Phb1/Phb2 complex PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with prohibitin (PHB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of prohibitin (PHB) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of prohibitin (PHB) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr The proteomic assay from Vpr-expressing HTLV-1 transformed cells reveals apoptosis related protein changes, such as mitochondrial protein prohibitin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables complement component C3a binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables complement component C3b binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proteinase activated receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in CD40 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T-helper 17 type immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in activation of protein kinase C activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interleukin-6 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epigenetic regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in modulation by host of viral RNA genome replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glucocorticoid receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by competitive promoter binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in osteoblast differentiation HDA PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of complement activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in symbiont entry into host cell ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of mitochondrial prohibitin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial prohibitin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prohibitin 1
Names
epididymis luminal protein 215
epididymis secretory sperm binding protein Li 54e
prohibitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023046.2 RefSeqGene

    Range
    5000..15830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281496.2 → NP_001268425.1  prohibitin 1 isoform 1

    See identical proteins and their annotated locations for NP_001268425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC091180
    Consensus CDS
    CCDS11548.1
    UniProtKB/Swiss-Prot
    B4DY47, P35232, Q4VBQ0
    UniProtKB/TrEMBL
    A8K401, Q53FV0, Q6PUJ7
    Related
    ENSP00000484113.1, ENST00000617874.5
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_001281497.2 → NP_001268426.1  prohibitin 1 isoform 2

    See identical proteins and their annotated locations for NP_001268426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate in-frame splice sites and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC091180
    Consensus CDS
    CCDS62244.1
    UniProtKB/Swiss-Prot
    P35232
    Related
    ENSP00000512581.1, ENST00000696365.1
    Conserved Domains (1) summary
    cd03401
    Location:27 → 141
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. NM_001281715.2 → NP_001268644.1  prohibitin 1 isoform 1

    See identical proteins and their annotated locations for NP_001268644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC091180
    Consensus CDS
    CCDS11548.1
    UniProtKB/Swiss-Prot
    B4DY47, P35232, Q4VBQ0
    UniProtKB/TrEMBL
    A8K401, Q53FV0, Q6PUJ7
    Related
    ENSP00000479488.1, ENST00000614445.5
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  4. NM_002634.4 → NP_002625.1  prohibitin 1 isoform 1

    See identical proteins and their annotated locations for NP_002625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC091180
    Consensus CDS
    CCDS11548.1
    UniProtKB/Swiss-Prot
    B4DY47, P35232, Q4VBQ0
    UniProtKB/TrEMBL
    A8K401, Q53FV0, Q6PUJ7
    Related
    ENSP00000300408.3, ENST00000300408.8
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    49404052..49414882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024763.2 → XP_016880252.1  prohibitin 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DY47, P35232, Q4VBQ0
    UniProtKB/TrEMBL
    A8K401, Q53FV0, Q6PUJ7
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    50267083..50277908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316505.1 → XP_054172480.1  prohibitin 1 isoform X1

    UniProtKB/Swiss-Prot
    B4DY47, P35232, Q4VBQ0
    UniProtKB/TrEMBL
    A8K401
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35232.1 GenPept UniProtKB/Swiss-Prot:P35232

Gene LinkOut

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