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PEG3 paternally expressed 3 [ Homo sapiens (human) ]

Gene ID: 5178, updated on 5-Mar-2024

Summary

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Official Symbol
PEG3provided by HGNC
Official Full Name
paternally expressed 3provided by HGNC
Primary source
HGNC:HGNC:8826
See related
Ensembl:ENSG00000198300 MIM:601483; AllianceGenome:HGNC:8826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PW1; ZNF904; ZSCAN24; ZKSCAN22
Summary
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
Expression
Biased expression in ovary (RPKM 126.4), placenta (RPKM 67.7) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.43
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56810082..56840726, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59905167..59935794, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57321450..57352094, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AH member 1 pseudogene Neighboring gene ZIM2 antisense RNA 1 Neighboring gene zinc finger imprinted 2 Neighboring gene PEG3 antisense RNA 1 Neighboring gene MER1 repeat containing imprinted transcript 1 Neighboring gene uncharacterized LOC124904779

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer. Zhang M, et al. Biosci Rep, 2020 Aug 28. PMID 32729618, Free PMC Article
  2. Reduced expression of Paternally Expressed Gene-3 enhances somatic cell reprogramming through mitochondrial activity perturbation. Theka I, et al. Sci Rep, 2017 Aug 29. PMID 28852087, Free PMC Article
  3. Resident PW1+ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension. Dierick F, et al. Circ Res, 2016 Mar 4. PMID 26838788
  4. PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence. Bonfanti C, et al. Nat Commun, 2015 Mar 9. PMID 25751651, Free PMC Article
  5. Structure of the SCAN domain of human paternally expressed gene 3 protein. Rimsa V, et al. PLoS One, 2013. PMID 23936039, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
    Title: Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
  2. miR-155-5p Promotes Cell Proliferation and Migration of Clear Cell Renal Cell Carcinoma by Targeting PEG3.
    Title: miR-155-5p Promotes Cell Proliferation and Migration of Clear Cell Renal Cell Carcinoma by Targeting PEG3.
  3. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
    Title: HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
  4. PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer.
    Title: PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer.
  5. These key findings demonstrated that upregulation of ZNF667-AS1 could suppress the progression of cervical cancer via the modulation of miR-93-3p-dependent PEG3.
    Title: Long noncoding RNA ZNF667-AS1 reduces tumor invasion and metastasis in cervical cancer by counteracting microRNA-93-3p-dependent PEG3 downregulation.
  6. Soluble matrix-derived cues being transduced downstream of receptor engagement converge upon a newly-discovered nexus of autophagic machinery consisting of Peg3 for endothelial cell autophagy and mitostatin for tumor cell mitophagy.
    Title: Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.
  7. Peg3 expression levels anti-correlate with pluripotency and increase gradually upon ESC differentiation. Moreover, downregulation of Peg3 enhances the efficiency of reprogramming of differentiated cells towards pluripotency.
    Title: Reduced expression of Paternally Expressed Gene-3 enhances somatic cell reprogramming through mitochondrial activity perturbation.
  8. Data suggest that PEG3 is required for TFEB induction and nuclear translocation in a VEGFR2- and AMPK-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB = transcription factor EB; VEGFR2 = vascular endothelial growth factor receptor-2; AMPK = AMP-activated protein kinase)
    Title: Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy.
  9. Peg3 transcriptionally modulates BECN1 activity.
    Title: Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis.
  10. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.
    Title: Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-05-17)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-05-17)

ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0287, DKFZp781A095

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
paternally-expressed gene 3 protein
Names
Kruppel-type zinc finger protein
zinc finger and SCAN domain-containing protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012989.1 RefSeqGene

    Range
    5004..35648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146184.2 → NP_001139656.1  paternally-expressed gene 3 protein isoform 1

    See identical proteins and their annotated locations for NP_001139656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing a 5' non-coding exon, therefore, has a shorter 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AF208967, AF208968, AI089069, AK295679, BC037330, CR933682
    Consensus CDS
    CCDS12948.1
    UniProtKB/Swiss-Prot
    A7E2B8, B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZU2, Q9GZY2
    UniProtKB/TrEMBL
    Q96Q96
    Related
    ENSP00000469486.1, ENST00000599577.5
    Conserved Domains (5) summary
    PHA00666
    Location:1421 → 1501
    PHA00666; putative protease
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:969 → 991
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 124
    SCAN; SCAN domain
    pfam08648
    Location:141 → 237
    DUF1777; Protein of unknown function (DUF1777)

  2. NM_001146185.2 → NP_001139657.1  paternally-expressed gene 3 protein isoform 2

    See identical proteins and their annotated locations for NP_001139657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing a 5' non-coding exon, and uses an alternate acceptor splice site at the first coding exon compared to variant 1. This results in the use of an in-frame downstream start codon, and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF208967, AF208969, AI089069, AK295679, BC037330, CR933682
    Consensus CDS
    CCDS58685.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000472402.1, ENST00000593695.5
    Conserved Domains (4) summary
    PHA00666
    Location:1295 → 1375
    PHA00666; putative protease
    sd00017
    Location:381 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:843 → 865
    zf-C2H2; Zinc finger, C2H2 type
    pfam08648
    Location:15 → 111
    DUF1777; Protein of unknown function (DUF1777)

  3. NM_001146187.2 → NP_001139659.1  paternally-expressed gene 3 protein isoform 3

    See identical proteins and their annotated locations for NP_001139659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is missing a 5' non-coding exon, and uses alternate splice sites at several coding exons compared to variant 1. This results in the use of an in-frame downstream start codon, and an isoform (3) with a shorter N-terminus and two additional internal aa compared to isoform 1. Variants 5, 9-22, and 30 all encode the same isoform (3).
    Source sequence(s)
    AB006625, AF208967, AI089069, AK295679, BC037330, CR933682
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000473190.1, ENST00000598410.5
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  4. NM_001369717.1 → NP_001356646.1  paternally-expressed gene 3 protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes the longest isoform (4).
    Source sequence(s)
    AC006115
    UniProtKB/TrEMBL
    Q96Q96
    Conserved Domains (4) summary
    PHA03169
    Location:1421 → 1505
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:509 → 529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:971 → 993
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain

  5. NM_001369718.1 → NP_001356647.1  paternally-expressed gene 3 protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes the longest isoform (4).
    Source sequence(s)
    AC006115
    UniProtKB/TrEMBL
    Q96Q96
    Conserved Domains (4) summary
    PHA03169
    Location:1421 → 1505
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:509 → 529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:971 → 993
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain

  6. NM_001369719.1 → NP_001356648.1  paternally-expressed gene 3 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006115
    UniProtKB/TrEMBL
    Q96Q96
    Conserved Domains (4) summary
    PHA03169
    Location:1390 → 1474
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:478 → 498
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:940 → 962
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain

  7. NM_001369720.1 → NP_001356649.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 5, 10-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000497332.1, ENST00000647852.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  8. NM_001369721.1 → NP_001356650.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 5, 9, 11-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  9. NM_001369722.1 → NP_001356651.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 5, 9, 10, 12-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000497512.1, ENST00000649680.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  10. NM_001369723.1 → NP_001356652.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 5, 9-11, 13-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000497466.1, ENST00000650102.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  11. NM_001369724.1 → NP_001356653.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 5, 9-12, 14-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  12. NM_001369725.1 → NP_001356654.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 5, 9-13, 15-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  13. NM_001369726.1 → NP_001356655.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 5, 9-14, 16-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000497971.1, ENST00000650632.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  14. NM_001369727.1 → NP_001356656.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 5, 9-15, 17-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  15. NM_001369728.1 → NP_001356657.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 5, 9-16, 18-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000496867.1, ENST00000649876.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  16. NM_001369729.1 → NP_001356658.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 5, 9-17, 19-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  17. NM_001369730.1 → NP_001356659.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 5, 9-18, 20-22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  18. NM_001369731.1 → NP_001356660.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 5, 9-19, 21, 22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000498047.1, ENST00000649233.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  19. NM_001369732.1 → NP_001356661.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 5, 9-20, 22, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  20. NM_001369733.1 → NP_001356662.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 5, 9-21, and 30, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000498138.1, ENST00000649428.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  21. NM_001369734.1 → NP_001356663.1  paternally-expressed gene 3 protein isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 24-27, encodes isoform 6.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS92696.1
    UniProtKB/TrEMBL
    A0A3B3IRU6, B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1264 → 1348
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:814 → 836
    zf-C2H2; Zinc finger, C2H2 type

  22. NM_001369735.1 → NP_001356664.1  paternally-expressed gene 3 protein isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 23 and 25-27, encodes isoform 6.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS92696.1
    UniProtKB/TrEMBL
    A0A3B3IRU6, B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1264 → 1348
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:814 → 836
    zf-C2H2; Zinc finger, C2H2 type

  23. NM_001369736.1 → NP_001356665.1  paternally-expressed gene 3 protein isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 23, 24, 26, and 27, encodes isoform 6.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS92696.1
    UniProtKB/TrEMBL
    A0A3B3IRU6, B9EG68
    Related
    ENSP00000496853.1, ENST00000647621.1
    Conserved Domains (3) summary
    PHA03169
    Location:1264 → 1348
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:814 → 836
    zf-C2H2; Zinc finger, C2H2 type

  24. NM_001369737.1 → NP_001356666.1  paternally-expressed gene 3 protein isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 23-25 and 27, encodes isoform 6.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS92696.1
    UniProtKB/TrEMBL
    A0A3B3IRU6, B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1264 → 1348
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:814 → 836
    zf-C2H2; Zinc finger, C2H2 type

  25. NM_001369738.1 → NP_001356667.1  paternally-expressed gene 3 protein isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 23-26, encodes isoform 6.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS92696.1
    UniProtKB/TrEMBL
    A0A3B3IRU6, B9EG68
    Conserved Domains (3) summary
    PHA03169
    Location:1264 → 1348
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:814 → 836
    zf-C2H2; Zinc finger, C2H2 type

  26. NM_001369739.1 → NP_001356668.1  paternally-expressed gene 3 protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 5 and 9-22, encodes isoform 3.
    Source sequence(s)
    AC006115
    Consensus CDS
    CCDS58684.1
    UniProtKB/TrEMBL
    B9EG68
    Related
    ENSP00000496914.1, ENST00000648694.1
    Conserved Domains (3) summary
    PHA03169
    Location:1295 → 1379
    PHA03169; hypothetical protein; Provisional
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:845 → 867
    zf-C2H2; Zinc finger, C2H2 type

  27. NM_006210.3 → NP_006201.1  paternally-expressed gene 3 protein isoform 1

    See identical proteins and their annotated locations for NP_006201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AF208967, AI089069, AK295679, BC037330, CR933682
    Consensus CDS
    CCDS12948.1
    UniProtKB/Swiss-Prot
    A7E2B8, B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZU2, Q9GZY2
    UniProtKB/TrEMBL
    Q96Q96
    Related
    ENSP00000326581.7, ENST00000326441.15
    Conserved Domains (5) summary
    PHA00666
    Location:1421 → 1501
    PHA00666; putative protease
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:969 → 991
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 124
    SCAN; SCAN domain
    pfam08648
    Location:141 → 237
    DUF1777; Protein of unknown function (DUF1777)

RNA

  1. NR_161475.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006115

  2. NR_161476.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006115

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56810082..56840726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59905167..59935794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146186.1: Suppressed sequence

    Description
    NM_001146186.1: This RefSeq was removed because currently there is insufficient support for the 5' end of the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZU2.1 GenPept UniProtKB/Swiss-Prot:Q9GZU2

Gene LinkOut

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