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MED15 mediator complex subunit 15 [ Homo sapiens (human) ]

Gene ID: 51586, updated on 3-Apr-2024

Summary

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Official Symbol
MED15provided by HGNC
Official Full Name
mediator complex subunit 15provided by HGNC
Primary source
HGNC:HGNC:14248
See related
Ensembl:ENSG00000099917 MIM:607372; AllianceGenome:HGNC:14248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105
Summary
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in spleen (RPKM 10.5), bone marrow (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

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See MED15 in Genome Data Viewer
Location:
22q11.21
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20507610..20587619)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20916219..20996263)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20861897..20941906)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 22 Neighboring gene keratin 18 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13496 Neighboring gene uncharacterized LOC101928824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20850596-20851248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20859501-20860000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18680 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20884447-20885434 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20903520-20904510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18681 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62813 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18682 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62834 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62844 Neighboring gene uncharacterized LOC124905084 Neighboring gene coiled-coil domain containing 74B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20954774-20954964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20964690-20965288 Neighboring gene sphingomyelin phosphodiesterase 4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator. Sanborn AL, et al. Elife, 2021 Apr 27. PMID 33904398, Free PMC Article
  2. MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation. Batlle C, et al. Commun Biol, 2021 Mar 26. PMID 33772081, Free PMC Article
  3. The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma. Weiten R, et al. Cancer Biomark, 2018. PMID 29400661
  4. MED15: a potential biomarker for head and neck squamous cell carcinoma? Offermann A, et al. Biomark Med, 2015. PMID 26457685
  5. Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors. Klümper N, et al. Diagn Pathol, 2015 Sep 17. PMID 26377566, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cystic MED15::TFE3 translocation renal cell carcinoma: histologic mimicker of multilocular cystic renal neoplasm of low malignant potential with review of the literature.
    Title: Cystic MED15::TFE3 translocation renal cell carcinoma: histologic mimicker of multilocular cystic renal neoplasm of low malignant potential with review of the literature.
  2. Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.
    Title: Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator.
  3. MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.
    Title: MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.
  4. MED15, transforming growth factor beta 1 (TGF-beta1), FcgammaRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.
    Title: MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma.
  5. In this article, we described MED15-TFE3 renal cell carcinoma (RCC), a rare gene subtype of Xp11 translocation RCCs, that was confirmed by FISH and RNA sequencing. The tumor demonstrated different morphological features and immunophenotypic characteristics with the cases reported in literatures, expanding our understanding on heterogeneity of MED15-TFE3 RCC.
    Title: A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion.
  6. MED15 does seem to play a tumour promoting role in the progression and metastatic spread of renal cell carcinoma
    Title: The Mediator complex subunit MED15, a promoter of tumour progression and metastatic spread in renal cell carcinoma.
  7. MED15 overexpression arises during androgen deprivation therapy via hyper-activation of PI3K/Akt/mTOR signaling pathway in prostate cancer cells.
    Title: MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling.
  8. MED15 as a potential biomarker for head and neck squamous cell carcinoma
    Title: MED15: a potential biomarker for head and neck squamous cell carcinoma?
  9. MED15 is differentially expressed in tumor-free testis and testicular germ cell tumors
    Title: Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors.
  10. MED15 overexpression is a clonal event during head and neck squamous cell carcinoma progression.
    Title: Clinical and molecular implications of MED15 in head and neck squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 15 (MED15) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42282, FLJ42935, DKFZp686A2214, DKFZp762B1216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 15
Names
CTG repeat protein 7a
PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
PC2 glutamine/Q-rich-associated protein
PC2-glutamine-rich-associated protein
TPA inducible gene-1
TPA inducible protein
TPA-inducible gene 1 protein
activator-recruited cofactor 105 kDa component
activator-recruited cofactor, 105-kD
positive cofactor 2, glutamine/Q-rich-associated protein
trinucleotide repeat containing 7
trinucleotide repeat-containing gene 7 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003891.3 → NP_001003891.1  mediator of RNA polymerase II transcription subunit 15 isoform a

    See identical proteins and their annotated locations for NP_001003891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK090465, BC003078, BC005027
    Consensus CDS
    CCDS33602.1
    UniProtKB/Swiss-Prot
    D3DX31, D3DX32, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q96RN5, Q9P1T3
    UniProtKB/TrEMBL
    B7Z2H7
    Related
    ENSP00000263205.7, ENST00000263205.11
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 784
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. NM_001293234.2 → NP_001280163.1  mediator of RNA polymerase II transcription subunit 15 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AK315540, BC005027
    UniProtKB/TrEMBL
    B7Z2H7
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 727
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. NM_001293235.2 → NP_001280164.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    See identical proteins and their annotated locations for NP_001280164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
    Source sequence(s)
    BC003078, BC005027, BC013985, DA182752
    Consensus CDS
    CCDS77653.1
    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
    Related
    ENSP00000384344.1, ENST00000406969.5
    Conserved Domains (1) summary
    pfam09606
    Location:1 → 718
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  4. NM_001293236.2 → NP_001280165.1  mediator of RNA polymerase II transcription subunit 15 isoform e

    See identical proteins and their annotated locations for NP_001280165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform e) is shorter, compared to isoform a.
    Source sequence(s)
    BC003078, BC005027, CR456537, DA182752
    Consensus CDS
    CCDS74824.1
    UniProtKB/TrEMBL
    B7Z2H7
    Related
    ENSP00000372434.2, ENST00000382974.6
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 78
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  5. NM_001293237.2 → NP_001280166.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    See identical proteins and their annotated locations for NP_001280166.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter, compared to isoform a. Variants 4 and 6 encode the same protein (isoform d).
    Source sequence(s)
    AC007731, AK294734, BC005027, CB156495
    Consensus CDS
    CCDS77653.1
    UniProtKB/TrEMBL
    B7Z2H7, G3V1P5
    Conserved Domains (1) summary
    pfam09606
    Location:1 → 718
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  6. NM_015889.5 → NP_056973.2  mediator of RNA polymerase II transcription subunit 15 isoform b

    See identical proteins and their annotated locations for NP_056973.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC005027, BC013985, DA182752
    Consensus CDS
    CCDS13781.1
    UniProtKB/TrEMBL
    B7Z2H7
    Related
    ENSP00000292733.7, ENST00000292733.11
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 744
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20507610..20587619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441395.1 → XP_047297351.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

  2. XM_047441398.1 → XP_047297354.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    G3V1P5

  3. XM_047441401.1 → XP_047297357.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

  4. XM_047441399.1 → XP_047297355.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

  5. XM_011530219.3 → XP_011528521.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

    See identical proteins and their annotated locations for XP_011528521.1

    Conserved Domains (1) summary
    pfam09606
    Location:17 → 149
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  6. XM_011530218.4 → XP_011528520.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

    Conserved Domains (1) summary
    pfam09606
    Location:17 → 361
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  7. XM_017028821.3 → XP_016884310.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

  8. XM_047441396.1 → XP_047297352.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

  9. XM_047441402.1 → XP_047297358.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

  10. XM_047441397.1 → XP_047297353.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

  11. XM_047441400.1 → XP_047297356.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

  12. XM_047441403.1 → XP_047297359.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

    UniProtKB/TrEMBL
    B3KWF1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20916219..20996263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325677.1 → XP_054181652.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

  2. XM_054325680.1 → XP_054181655.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    G3V1P5

  3. XM_054325683.1 → XP_054181658.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

  4. XM_054325681.1 → XP_054181656.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

  5. XM_054325687.1 → XP_054181662.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

  6. XM_054325686.1 → XP_054181661.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

  7. XM_054325685.1 → XP_054181660.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

  8. XM_054325678.1 → XP_054181653.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

  9. XM_054325684.1 → XP_054181659.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

  10. XM_054325679.1 → XP_054181654.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

  11. XM_054325682.1 → XP_054181657.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

  12. XM_054325688.1 → XP_054181663.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

    UniProtKB/TrEMBL
    B3KWF1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RN5.2 GenPept UniProtKB/Swiss-Prot:Q96RN5

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