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CINP cyclin dependent kinase 2 interacting protein [ Homo sapiens (human) ]

Gene ID: 51550, updated on 5-Mar-2024

Summary

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Official Symbol
CINPprovided by HGNC
Official Full Name
cyclin dependent kinase 2 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:23789
See related
Ensembl:ENSG00000100865 MIM:613362; AllianceGenome:HGNC:23789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in testis (RPKM 6.8), brain (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
14q32.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102348282..102362890, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96583876..96598485, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102814619..102829227, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6115 Neighboring gene uncharacterized LOC124903389 Neighboring gene uncharacterized LOC124903440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9072 Neighboring gene tectonin beta-propeller repeat containing 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:102877147-102878136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102906165-102906672 Neighboring gene RNA, U6 small nuclear 244, pseudogene Neighboring gene ankyrin repeat domain 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Paulsen RD, et al. Mol Cell, 2009 Jul 31. PMID 19647519, Free PMC Article
  2. Modification of gene expression by melatonin in UVB-irradiated HaCaT keratinocyte cell lines using a cDNA microarray. Cho JW, et al. Oncol Rep, 2007 Mar. PMID 17273735
  3. CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth. Wu Q, et al. Int J Cancer, 2019 Feb 1. PMID 30289973, Free PMC Article
  4. Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP). Wang Y, et al. J Biol Chem, 2011 Jul 29. PMID 21628470, Free PMC Article
  5. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Kalay E, et al. Nat Genet, 2011 Jan. PMID 21131973, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing CINP had the most potent inhibitory effect on cell growth in KLF5-expressing cells but did not affect parental TSU-Pr1 cells. Further analyses not only confirmed the physical interaction between KLF5 and CINP, also demonstrated that knockdown of CINP attenuated the effects of KLF5 on cell cycle progression, apoptosis and tumorigenesis.
    Title: CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth.
  2. NS5B delays cells in S phase through interaction with CINP and relocalization of the protein from the nucleus to the cytoplasm
    Title: Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).
  3. CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity.
    Title: Functional genomic screens identify CINP as a genome maintenance protein.
  4. CINP is part of the Cdc7-dependent mechanism of origin firing and a functional and physical link between Cdk2 and Cdc7 complexes at the origins
    Title: A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables preribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 2-interacting protein
Names
CDK2-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320046.2 → NP_001306975.1  cyclin-dependent kinase 2-interacting protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL137229, DA167716
    Consensus CDS
    CCDS53915.1
    UniProtKB/TrEMBL
    H0YKY0
    Related
    ENSP00000442377.2, ENST00000541568.6

  2. NM_032630.3 → NP_116019.1  cyclin-dependent kinase 2-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_116019.1

    Status: REVIEWED

    Source sequence(s)
    BC000600, DA351468, EL951117
    Consensus CDS
    CCDS9972.1
    UniProtKB/Swiss-Prot
    F5H7P3, F5H8A7, Q9BW66, Q9NPF9
    UniProtKB/TrEMBL
    Q86TU0
    Related
    ENSP00000216756.6, ENST00000216756.11

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102348282..102362890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96583876..96598485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177611.1: Suppressed sequence

    Description
    NM_001177611.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001177612.1: Suppressed sequence

    Description
    NM_001177612.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BW66.1 GenPept UniProtKB/Swiss-Prot:Q9BW66

Gene LinkOut

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