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PDE9A phosphodiesterase 9A [ Homo sapiens (human) ]

Gene ID: 5152, updated on 11-Apr-2024

Summary

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Official Symbol
PDE9Aprovided by HGNC
Official Full Name
phosphodiesterase 9Aprovided by HGNC
Primary source
HGNC:HGNC:8795
See related
Ensembl:ENSG00000160191 MIM:602973; AllianceGenome:HGNC:8795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPDE9A2
Summary
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues See more
Orthologs
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Genomic context

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See PDE9A in Genome Data Viewer
Location:
21q22.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (42653621..42775509)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41042071..41163988)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44073731..44195619)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 1 Neighboring gene uncharacterized LOC101928212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13349 Neighboring gene VISTA enhancer hs2248 Neighboring gene MPRA-validated peak4415 silencer Neighboring gene long intergenic non-protein coding RNA 1671 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44037913-44038824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44057507-44058403 Neighboring gene uncharacterized LOC101928255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44072695-44073416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44081521-44082390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44086147-44086653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44088149-44089095 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44089096-44090041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44122945-44123824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44126986-44127486 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:44144061-44145260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44158941-44159941 Neighboring gene PDE9A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44176879-44177378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44181049-44181582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44181583-44182114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44187499-44187998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44191023-44191524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44195549-44196050 Neighboring gene uncharacterized LOC107985504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44197711-44198660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44199612-44200561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44201049-44201772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44202497-44203220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44203221-44203942 Neighboring gene long intergenic non-protein coding RNA 1668 Neighboring gene NANOG hESC enhancer GRCh37_chr21:44220991-44221572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44254625-44255576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44268253-44268818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44268819-44269384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44280271-44280829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44285917-44286612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44297711-44298674 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44298675-44299639 Neighboring gene uncharacterized LOC105372817 Neighboring gene WD repeat domain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. Susmi TF, et al. BMC Cancer, 2021 May 20. PMID 34016083, Free PMC Article
  2. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. Kleiman RJ, et al. J Pharmacol Exp Ther, 2012 May. PMID 22328573
  3. Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals. Miguel LI, et al. Inflamm Res, 2011 Jul. PMID 21336703
  4. Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene. Rentero C, et al. BMC Mol Biol, 2006 Nov 8. PMID 17090334, Free PMC Article
  5. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Huai Q, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15210993, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.
    Title: Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.
  2. Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.
    Title: Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.
  3. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.
    Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
  4. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer
    Title: Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors.
  5. In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory.
    Title: Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
  6. PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5.
    Title: Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study.
  7. Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin and CD11b adhesion molecules.
    Title: Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Poor replication of candidate genes for major depressive disorder using genome-wide association data.
  10. PDE9A, is unlikely to play an important role in antidepressant outcome in this sample
    Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of phosphodiesterase 9A (PDE9A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Names
CGMP-specific 3',5'-cyclic phosphodiesterase type 9
phosphodiesterase PDE9A21
NP_001001567.1
NP_001001568.1
NP_001001569.1
NP_001001570.1
NP_001001571.1
NP_001001572.1
NP_001001573.1
NP_001001574.1
NP_001001575.1
NP_001001576.1
NP_001001577.1
NP_001001578.1
NP_001001579.1
NP_001001580.1
NP_001001581.1
NP_001001582.1
NP_001001583.1
NP_001001584.1
NP_001001585.1
NP_001302462.1
NP_002597.1
XP_011527900.1
XP_011527902.1
XP_016883855.1
XP_054180516.1
XP_054180517.1
XP_054180518.1
XP_054180519.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047067.1 RefSeqGene

    Range
    4870..126758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001567.2 → NP_001001567.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b

    See identical proteins and their annotated locations for NP_001001567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but lacks an internal segment compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AF067224, AI492065, AP001626, BC009047
    Consensus CDS
    CCDS33568.1
    UniProtKB/TrEMBL
    A0A0S2Z4A3
    Related
    ENSP00000335242.4, ENST00000335512.8
    Conserved Domains (1) summary
    pfam00233
    Location:251 → 479
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001001568.2 → NP_001001568.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c

    See identical proteins and their annotated locations for NP_001001568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. The resulting predicted isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AF067225, AI492065, AP001626, AY196305, BC009047
    Consensus CDS
    CCDS42946.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381280.3, ENST00000398224.3
    Conserved Domains (1) summary
    pfam00233
    Location:184 → 412
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_001001569.2 → NP_001001569.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d

    See identical proteins and their annotated locations for NP_001001569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four alternate exons compared to variant 1. The resulting predicted isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AF067226, AI492065, AP001626, AY196305, BC009047
    Consensus CDS
    CCDS33571.1
    UniProtKB/TrEMBL
    A0A0S2Z475
    Related
    ENSP00000344730.3, ENST00000349112.7
    Conserved Domains (1) summary
    pfam00233
    Location:183 → 411
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. NM_001001570.2 → NP_001001570.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e

    See identical proteins and their annotated locations for NP_001001570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon and lacks two others compared to variant 1. The resulting isoform (e) has the same N- and C-termini but differs in an internal segment compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196299, BC009047
    Consensus CDS
    CCDS33567.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000369685.2, ENST00000380328.6
    Conserved Domains (1) summary
    pfam00233
    Location:258 → 486
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. NM_001001571.2 → NP_001001571.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f

    See identical proteins and their annotated locations for NP_001001571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting predicted isoform (f) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196300, BC009047
    Consensus CDS
    CCDS42943.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381289.3, ENST00000398234.7
    Conserved Domains (1) summary
    pfam00233
    Location:210 → 438
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. NM_001001572.2 → NP_001001572.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

    See identical proteins and their annotated locations for NP_001001572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196301, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000467403.5
    Conserved Domains (1) summary
    pfam00233
    Location:104 → 332
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  7. NM_001001573.2 → NP_001001573.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

    See identical proteins and their annotated locations for NP_001001573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196302, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000490803.5
    Conserved Domains (1) summary
    pfam00233
    Location:104 → 332
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  8. NM_001001574.2 → NP_001001574.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h

    See identical proteins and their annotated locations for NP_001001574.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (h) has the same N- and C-termini but lacks two internal segments compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196303, BC009047
    Consensus CDS
    CCDS42941.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381291.3, ENST00000398236.7
    Conserved Domains (1) summary
    pfam00233
    Location:225 → 453
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  9. NM_001001575.2 → NP_001001575.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i

    See identical proteins and their annotated locations for NP_001001575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks five alternate exons compared to variant 1. The resulting predicted isoform (i) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196304, BC009047
    Consensus CDS
    CCDS42947.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381283.3, ENST00000398227.7
    Conserved Domains (1) summary
    pfam00233
    Location:151 → 379
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  10. NM_001001576.2 → NP_001001576.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

    See identical proteins and their annotated locations for NP_001001576.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks five alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196305, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000495521.5
    Conserved Domains (1) summary
    pfam00233
    Location:94 → 322
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  11. NM_001001577.2 → NP_001001577.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k

    See identical proteins and their annotated locations for NP_001001577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks four alternate exons compared to variant 1. The resulting predicted isoform (k) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196306, BC009047
    Consensus CDS
    CCDS42944.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381285.3, ENST00000398229.7
    Conserved Domains (1) summary
    pfam00233
    Location:177 → 405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  12. NM_001001578.2 → NP_001001578.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l

    See identical proteins and their annotated locations for NP_001001578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) lacks three alternate exons compared to variant 1. The resulting isoform (l) has the same N- and C-termini but lacks two internal segments compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196307, BC009047
    Consensus CDS
    CCDS33570.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000335365.6, ENST00000335440.10
    Conserved Domains (1) summary
    pfam00233
    Location:209 → 437
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  13. NM_001001579.2 → NP_001001579.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

    See identical proteins and their annotated locations for NP_001001579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196308, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000468805.5
    Conserved Domains (1) summary
    pfam00233
    Location:104 → 332
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  14. NM_001001580.2 → NP_001001580.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

    See identical proteins and their annotated locations for NP_001001580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) lacks six alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196309, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000460989.5
    Conserved Domains (1) summary
    pfam00233
    Location:94 → 322
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  15. NM_001001581.2 → NP_001001581.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m

    See identical proteins and their annotated locations for NP_001001581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks two alternate exons compared to variant 1. The resulting predicted isoform (m) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196310, BC009047
    Consensus CDS
    CCDS42945.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381287.3, ENST00000398232.7
    Conserved Domains (1) summary
    pfam00233
    Location:244 → 472
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  16. NM_001001582.2 → NP_001001582.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n

    See identical proteins and their annotated locations for NP_001001582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks an alternate exon compared to variant 1. The resulting predicted isoform (n) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196311, BC009047
    Consensus CDS
    CCDS42942.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000381281.3, ENST00000398225.7
    Conserved Domains (1) summary
    pfam00233
    Location:270 → 498
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  17. NM_001001583.2 → NP_001001583.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o

    See identical proteins and their annotated locations for NP_001001583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (o) has the same N- and C-termini but lacks an internal segment compared to isoform a.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196312, BC009047
    Consensus CDS
    CCDS33569.1
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENSP00000328699.6, ENST00000328862.10
    Conserved Domains (1) summary
    pfam00233
    Location:285 → 513
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  18. NM_001001584.3 → NP_001001584.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

    See identical proteins and their annotated locations for NP_001001584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) contains an alternate exon and lacks three others compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AP001627, AY196313, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000462571.5
    Conserved Domains (1) summary
    pfam00233
    Location:104 → 332
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  19. NM_001001585.2 → NP_001001585.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

    See identical proteins and their annotated locations for NP_001001585.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) lacks two alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, AY196314, BC009047
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000497805.5
    Conserved Domains (1) summary
    pfam00233
    Location:104 → 332
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  20. NM_001315533.2 → NP_001302462.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (p) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AI492065, AP001626, AP001628, AY701187
    UniProtKB/Swiss-Prot
    O76083
    Related
    ENST00000470987.5
    Conserved Domains (1) summary
    pfam00233
    Location:203 → 431
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  21. NM_002606.3 → NP_002597.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a

    See identical proteins and their annotated locations for NP_002597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF048837, AF067223, AI492065, AP001626, BC009047
    Consensus CDS
    CCDS13690.1
    UniProtKB/Swiss-Prot
    B2RBI5, B4DFI5, D3DSJ8, D3DSJ9, O75490, O75491, O76083, O95225, Q53Y40, Q5QD39, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0
    UniProtKB/TrEMBL
    A0A0S2Z4T6
    Related
    ENSP00000291539.6, ENST00000291539.11
    Conserved Domains (1) summary
    pfam00233
    Location:311 → 539
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    42653621..42775509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028366.2 → XP_016883855.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

    UniProtKB/Swiss-Prot
    O76083
    Conserved Domains (1) summary
    pfam00233
    Location:104 → 332
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_011529600.3 → XP_011527902.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:311 → 452
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_011529598.3 → XP_011527900.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:263 → 491
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    41042071..41163988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324544.1 → XP_054180519.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

  2. XM_054324543.1 → XP_054180518.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

  3. XM_054324542.1 → XP_054180517.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

  4. XM_054324541.1 → XP_054180516.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76083.1 GenPept UniProtKB/Swiss-Prot:O76083

Gene LinkOut

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