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GULP1 GULP PTB domain containing engulfment adaptor 1 [ Homo sapiens (human) ]

Gene ID: 51454, updated on 3-Apr-2024

Summary

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Official Symbol
GULP1provided by HGNC
Official Full Name
GULP PTB domain containing engulfment adaptor 1provided by HGNC
Primary source
HGNC:HGNC:18649
See related
Ensembl:ENSG00000144366 MIM:608165; AllianceGenome:HGNC:18649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED6; GULP; CED-6
Summary
The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in endometrium (RPKM 8.3), prostate (RPKM 7.5) and 22 other tissues See more
Orthologs
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Genomic context

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See GULP1 in Genome Data Viewer
Location:
2q32.1-q32.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (188291874..188595926)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (188780647..189084760)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (189156601..189460653)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1090 Neighboring gene MPRA-validated peak3993 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16845 Neighboring gene MPRA-validated peak3994 silencer Neighboring gene chromosome 18 open reading frame 25 pseudogene Neighboring gene Sharpr-MPRA regulatory region 8723 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:189143651-189144345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189158453-189159336 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:189163339-189164538 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:189167937-189168854 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:189168855-189169772 Neighboring gene RNA, 5S ribosomal pseudogene 114 Neighboring gene microRNA 561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189260185-189260684 Neighboring gene uncharacterized LOC124906107 Neighboring gene uncharacterized LOC105373790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:189538838-189539338 Neighboring gene disrupted in renal carcinoma 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. Gong J, et al. J Cell Biol, 2019 Oct 7. PMID 31409653, Free PMC Article
  2. Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1. Maldonado L, et al. Cancer Lett, 2018 Oct 1. PMID 29964205
  3. Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease. Datta S, et al. Respir Med, 2017 Mar. PMID 28284325
  4. Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells. Ma CI, et al. J Biol Chem, 2012 Jun 8. PMID 22451657, Free PMC Article
  5. GULP1 is a novel APP-interacting protein that alters APP processing. Hao Y, et al. Biochem J, 2011 Jun 15. PMID 21486224

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
    Title: GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
  2. Results indicate that GULP, engulfment adaptor PTB domain containing 1 (GULP1) threonine 35 (T35) phosphorylation is a mechanism for the regulation of GULP1-amyloid beta precursor protein (APP) interaction and thereby APP processing.
    Title: Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
  3. the phagocytic adaptor protein Gulp1 regulates EphB/ephrinB trogocytosis to achieve efficient cell rearrangements of cultured cells and during embryonic development
    Title: Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development.
  4. The knockdown of GULP1 and ABR using siRNAs decreased phagocytosis by 40%.
    Title: Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis.
  5. GULP1 methylation was associated with clinicopathological parameters such as stage III/IV, poorly differentiated grade, residual disease, worse overall and disease specific survival in ovarian cancer.
    Title: Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.
  6. This study highlights and provides new implications for the role of GULP1 associated molecular mechanism(s) in COPD-emphysema development or progression.
    Title: Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.
  7. GULP1 only mediates LRP1 transactivation
    Title: Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
  8. The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.
    Title: The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.
  9. GULP expression positively regulates TGF-beta signaling leading to growth inhibition, this may represent an attractive target to achieve TGF-beta responsiveness in ovarian cells.
    Title: Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells.
  10. This study identify GULP1 as a novel neuronal amyloid-beta precursor protein interacting protein that alters trafficking and processing of amyloid-beta precursor protein.
    Title: Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Upregulation of apoptosis genes such as NCK-associated protein 1, PTB domain adaptor protein CED-6, and TNF receptor superfamily 5 are induced by HIV-1 gp120 in human neurons PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31156

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PTB domain-containing engulfment adapter protein 1
Names
GULP, engulfment adaptor PTB domain containing 1
PTB domain adapter protein CED-6
PTB domain adaptor protein CED-6
cell death protein 6 homolog
engulfment adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252668.2 → NP_001239597.1  PTB domain-containing engulfment adapter protein 1 isoform b

    See identical proteins and their annotated locations for NP_001239597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS58742.1
    UniProtKB/TrEMBL
    B3KN52
    Related
    ENSP00000387144.1, ENST00000409843.5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam10211
    Location:136 → 198
    Ax_dynein_light; Axonemal dynein light chain

  2. NM_001252669.2 → NP_001239598.1  PTB domain-containing engulfment adapter protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame coding segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS58743.1
    UniProtKB/Swiss-Prot
    Q9UBP9
    Related
    ENSP00000387171.1, ENST00000409805.5
    Conserved Domains (2) summary
    cd14686
    Location:60 → 92
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cl17171
    Location:31 → 54
    PH-like; Pleckstrin homology-like domain

  3. NM_001375925.1 → NP_001362854.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 5, and 6-10, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Related
    ENSP00000352047.3, ENST00000359135.7
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  4. NM_001375926.1 → NP_001362855.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 4, and 6-10, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Related
    ENSP00000386289.1, ENST00000409580.5
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  5. NM_001375927.1 → NP_001362856.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7-10, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  6. NM_001375928.1 → NP_001362857.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8-10, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  7. NM_001375929.1 → NP_001362858.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 4-7, 9, and 10, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  8. NM_001375930.1 → NP_001362859.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 4-8, and 10, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  9. NM_001375931.1 → NP_001362860.1  PTB domain-containing engulfment adapter protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1 and 4-9, encodes isoform a.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  10. NM_001375932.1 → NP_001362861.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 12-18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Related
    ENSP00000514747.1, ENST00000699997.1
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  11. NM_001375933.1 → NP_001362862.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 11 and 13-18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  12. NM_001375934.1 → NP_001362863.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 11, 12, and 14-18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  13. NM_001375935.1 → NP_001362864.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 11-13 and 15-18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  14. NM_001375936.1 → NP_001362865.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 11-14 and 16-18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  15. NM_001375937.1 → NP_001362866.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 11-15, 17, and 18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  16. NM_001375938.1 → NP_001362867.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 11-16 and 18, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  17. NM_001375939.1 → NP_001362868.1  PTB domain-containing engulfment adapter protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 11-17, encodes isoform d.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92915.1
    UniProtKB/TrEMBL
    A0A8V8TQW5
    Conserved Domains (2) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl40461
    Location:150 → 191
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  18. NM_001375940.1 → NP_001362869.1  PTB domain-containing engulfment adapter protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 20-22, encodes isoform e.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  19. NM_001375941.1 → NP_001362870.1  PTB domain-containing engulfment adapter protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 19, 21, and 22, encodes isoform e.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  20. NM_001375942.1 → NP_001362871.1  PTB domain-containing engulfment adapter protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 19, 20, and 22, encodes isoform e.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  21. NM_001375943.1 → NP_001362872.1  PTB domain-containing engulfment adapter protein 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 19-21, encodes isoform e.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (1) summary
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  22. NM_001375944.1 → NP_001362873.1  PTB domain-containing engulfment adapter protein 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 24-26, encodes isoform f.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    TIGR02168
    Location:71 → 154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  23. NM_001375945.1 → NP_001362874.1  PTB domain-containing engulfment adapter protein 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 23, 25, and 26, encodes isoform f.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    TIGR02168
    Location:71 → 154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  24. NM_001375946.1 → NP_001362875.1  PTB domain-containing engulfment adapter protein 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 23, 24, and 26, encodes isoform f.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    TIGR02168
    Location:71 → 154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  25. NM_001375947.1 → NP_001362876.1  PTB domain-containing engulfment adapter protein 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 23-25, encodes isoform f.
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    TIGR02168
    Location:71 → 154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  26. NM_001375948.1 → NP_001362877.1  PTB domain-containing engulfment adapter protein 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variant 28, encodes the longest isoform (g).
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92916.1
    UniProtKB/TrEMBL
    B3KN52, H7BZV7
    Related
    ENSP00000391712.2, ENST00000433052.2
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  27. NM_001375949.1 → NP_001362878.1  PTB domain-containing engulfment adapter protein 1 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variant 27, encodes the longest isoform (g).
    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Consensus CDS
    CCDS92916.1
    UniProtKB/TrEMBL
    B3KN52, H7BZV7
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  28. NM_001375950.1 → NP_001362879.1  PTB domain-containing engulfment adapter protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (2) summary
    TIGR02168
    Location:71 → 154
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  29. NM_001375951.1 → NP_001362880.1  PTB domain-containing engulfment adapter protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (2) summary
    cd01273
    Location:3 → 129
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam10211
    Location:108 → 178
    Ax_dynein_light; Axonemal dynein light chain

  30. NM_001375952.1 → NP_001362881.1  PTB domain-containing engulfment adapter protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (2) summary
    cd14686
    Location:139 → 171
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 133
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  31. NM_001375953.1 → NP_001362882.1  PTB domain-containing engulfment adapter protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490
    Conserved Domains (1) summary
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  32. NM_016315.4 → NP_057399.1  PTB domain-containing engulfment adapter protein 1 isoform a

    See identical proteins and their annotated locations for NP_057399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 4, 5, and 6-10, encodes isoform a.
    Source sequence(s)
    AC092598, AF200715, AK055718, AK314498, AL080142
    Consensus CDS
    CCDS2295.1
    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    UniProtKB/TrEMBL
    B3KN52
    Related
    ENSP00000386732.1, ENST00000409830.6
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

RNA

  1. NR_164744.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490

  2. NR_164745.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092598, AC104131, AC108493, AC125490

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    188291874..188595926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712582.2 → XP_006712645.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006712645.1

    UniProtKB/TrEMBL
    B3KN52, H7BZV7
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  2. XM_047444715.1 → XP_047300671.1  PTB domain-containing engulfment adapter protein 1 isoform X13

  3. XM_011511333.2 → XP_011509635.1  PTB domain-containing engulfment adapter protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011509635.1

    Conserved Domains (2) summary
    cd14686
    Location:117 → 149
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  4. XM_047444714.1 → XP_047300670.1  PTB domain-containing engulfment adapter protein 1 isoform X12

  5. XM_011511329.2 → XP_011509631.1  PTB domain-containing engulfment adapter protein 1 isoform X2

    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  6. XM_047444704.1 → XP_047300660.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  7. XM_047444703.1 → XP_047300659.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  8. XM_047444697.1 → XP_047300653.1  PTB domain-containing engulfment adapter protein 1 isoform X6

  9. XM_047444712.1 → XP_047300668.1  PTB domain-containing engulfment adapter protein 1 isoform X12

  10. XM_047444699.1 → XP_047300655.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  11. XM_017004307.2 → XP_016859796.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    Conserved Domains (3) summary
    cd14686
    Location:117 → 149
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    pfam04880
    Location:121 → 200
    NUDE_C; NUDE protein, C-terminal conserved region
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  12. XM_006712589.4 → XP_006712652.1  PTB domain-containing engulfment adapter protein 1 isoform X7

    UniProtKB/TrEMBL
    B3KN52
    Conserved Domains (3) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    pfam04880
    Location:167 → 246
    NUDE_C; NUDE protein, C-terminal conserved region

  13. XM_011511335.3 → XP_011509637.1  PTB domain-containing engulfment adapter protein 1 isoform X10

    Conserved Domains (3) summary
    cd14686
    Location:117 → 149
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    pfam04880
    Location:121 → 200
    NUDE_C; NUDE protein, C-terminal conserved region
    cl17171
    Location:14 → 111
    PH-like; Pleckstrin homology-like domain

  14. XM_006712584.5 → XP_006712647.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006712647.1

    UniProtKB/TrEMBL
    B3KN52, H7BZV7
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  15. XM_047444696.1 → XP_047300652.1  PTB domain-containing engulfment adapter protein 1 isoform X5

  16. XM_047444709.1 → XP_047300665.1  PTB domain-containing engulfment adapter protein 1 isoform X11

  17. XM_006712583.5 → XP_006712646.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006712646.1

    UniProtKB/TrEMBL
    B3KN52, H7BZV7
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  18. XM_047444702.1 → XP_047300658.1  PTB domain-containing engulfment adapter protein 1 isoform X8

    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9
    Related
    ENSP00000386867.1, ENST00000409609.5

  19. XM_047444710.1 → XP_047300666.1  PTB domain-containing engulfment adapter protein 1 isoform X11

  20. XM_006712580.5 → XP_006712643.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006712643.1

    UniProtKB/TrEMBL
    B3KN52, H7BZV7
    Conserved Domains (2) summary
    cd14686
    Location:163 → 195
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:14 → 157
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  21. XM_047444695.1 → XP_047300651.1  PTB domain-containing engulfment adapter protein 1 isoform X5

  22. XM_047444692.1 → XP_047300648.1  PTB domain-containing engulfment adapter protein 1 isoform X2

  23. XM_047444707.1 → XP_047300663.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  24. XM_047444705.1 → XP_047300661.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  25. XM_047444713.1 → XP_047300669.1  PTB domain-containing engulfment adapter protein 1 isoform X12

  26. XM_047444701.1 → XP_047300657.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  27. XM_047444698.1 → XP_047300654.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  28. XM_047444708.1 → XP_047300664.1  PTB domain-containing engulfment adapter protein 1 isoform X10

  29. XM_047444706.1 → XP_047300662.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  30. XM_047444700.1 → XP_047300656.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  31. XM_047444711.1 → XP_047300667.1  PTB domain-containing engulfment adapter protein 1 isoform X11

  32. XM_047444691.1 → XP_047300647.1  PTB domain-containing engulfment adapter protein 1 isoform X2

  33. XM_047444693.1 → XP_047300649.1  PTB domain-containing engulfment adapter protein 1 isoform X4

  34. XM_011511331.2 → XP_011509633.1  PTB domain-containing engulfment adapter protein 1 isoform X3

    Conserved Domains (2) summary
    cd14686
    Location:150 → 182
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    cd01273
    Location:5 → 144
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

  35. XM_047444694.1 → XP_047300650.1  PTB domain-containing engulfment adapter protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    188780647..189084760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342469.1 → XP_054198444.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    H7BZV7

  2. XM_054342503.1 → XP_054198478.1  PTB domain-containing engulfment adapter protein 1 isoform X13

  3. XM_054342478.1 → XP_054198453.1  PTB domain-containing engulfment adapter protein 1 isoform X5

  4. XM_054342502.1 → XP_054198477.1  PTB domain-containing engulfment adapter protein 1 isoform X12

  5. XM_054342474.1 → XP_054198449.1  PTB domain-containing engulfment adapter protein 1 isoform X2

  6. XM_054342491.1 → XP_054198466.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  7. XM_054342490.1 → XP_054198465.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  8. XM_054342481.1 → XP_054198456.1  PTB domain-containing engulfment adapter protein 1 isoform X6

  9. XM_054342501.1 → XP_054198476.1  PTB domain-containing engulfment adapter protein 1 isoform X12

  10. XM_054342484.1 → XP_054198459.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  11. XM_054342497.1 → XP_054198472.1  PTB domain-containing engulfment adapter protein 1 isoform X10

  12. XM_054342482.1 → XP_054198457.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  13. XM_054342495.1 → XP_054198470.1  PTB domain-containing engulfment adapter protein 1 isoform X10

  14. XM_054342471.1 → XP_054198446.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    H7BZV7

  15. XM_054342480.1 → XP_054198455.1  PTB domain-containing engulfment adapter protein 1 isoform X5

  16. XM_054342498.1 → XP_054198473.1  PTB domain-containing engulfment adapter protein 1 isoform X11

  17. XM_054342472.1 → XP_054198447.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    H7BZV7

  18. XM_054342489.1 → XP_054198464.1  PTB domain-containing engulfment adapter protein 1 isoform X8

    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9

  19. XM_054342470.1 → XP_054198445.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    H7BZV7

  20. XM_054342488.1 → XP_054198463.1  PTB domain-containing engulfment adapter protein 1 isoform X8

    UniProtKB/Swiss-Prot
    B2RB51, B4DQ40, B8ZZ72, D3DPH1, E9PB86, Q53PC1, Q53RF3, Q9BVL3, Q9UBP9

  21. XM_054342499.1 → XP_054198474.1  PTB domain-containing engulfment adapter protein 1 isoform X11

  22. XM_054342468.1 → XP_054198443.1  PTB domain-containing engulfment adapter protein 1 isoform X1

    UniProtKB/TrEMBL
    H7BZV7

  23. XM_054342479.1 → XP_054198454.1  PTB domain-containing engulfment adapter protein 1 isoform X5

  24. XM_054342475.1 → XP_054198450.1  PTB domain-containing engulfment adapter protein 1 isoform X2

  25. XM_054342494.1 → XP_054198469.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  26. XM_054342493.1 → XP_054198468.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  27. XM_054342487.1 → XP_054198462.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  28. XM_054342486.1 → XP_054198461.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  29. XM_054342483.1 → XP_054198458.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  30. XM_054342496.1 → XP_054198471.1  PTB domain-containing engulfment adapter protein 1 isoform X10

  31. XM_054342492.1 → XP_054198467.1  PTB domain-containing engulfment adapter protein 1 isoform X9

  32. XM_054342485.1 → XP_054198460.1  PTB domain-containing engulfment adapter protein 1 isoform X7

  33. XM_054342500.1 → XP_054198475.1  PTB domain-containing engulfment adapter protein 1 isoform X11

  34. XM_054342473.1 → XP_054198448.1  PTB domain-containing engulfment adapter protein 1 isoform X2

  35. XM_054342476.1 → XP_054198451.1  PTB domain-containing engulfment adapter protein 1 isoform X3

  36. XM_054342477.1 → XP_054198452.1  PTB domain-containing engulfment adapter protein 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UBP9.1 GenPept UniProtKB/Swiss-Prot:Q9UBP9

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