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PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 [ Homo sapiens (human) ]

Gene ID: 51422, updated on 3-Apr-2024

Summary

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Official Symbol
PRKAG2provided by HGNC
Official Full Name
protein kinase AMP-activated non-catalytic subunit gamma 2provided by HGNC
Primary source
HGNC:HGNC:9386
See related
Ensembl:ENSG00000106617 MIM:602743; AllianceGenome:HGNC:9386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAKG; CMH6; WPWS; AAKG2; H91620p
Summary
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in heart (RPKM 15.2), prostate (RPKM 4.8) and 24 other tissues See more
Orthologs
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Genomic context

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See PRKAG2 in Genome Data Viewer
Location:
7q36.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (151556127..151877115, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (152728656..153049942, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151253213..151574200, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:151161805-151162306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26865 Neighboring gene NANOG hESC enhancer GRCh37_chr7:151187724-151188264 Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26866 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:151216232-151216661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18821 Neighboring gene Ras homolog, mTORC1 binding Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26867 Neighboring gene MPRA-validated peak6846 silencer Neighboring gene eukaryotic translation termination factor 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 3106 Neighboring gene MPRA-validated peak6847 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151289181-151289681 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151300425-151300977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151377353-151378020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151379739-151380324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151380325-151380908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151380909-151381493 Neighboring gene VISTA enhancer hs2193 Neighboring gene VISTA enhancer hs2194 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:151401658-151401849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151417955-151418476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151421977-151422477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:151423711-151424574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26869 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:151432471-151433128 Neighboring gene VISTA enhancer hs2199 Neighboring gene VISTA enhancer hs2200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151481003-151481892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151481893-151482782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151487603-151488104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151491193-151492090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151493035-151493617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151493618-151494199 Neighboring gene PRKAG2 antisense RNA 2 Neighboring gene MPRA-validated peak6848 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151535109-151535690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151551046-151551566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151551567-151552087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151584831-151585642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151585643-151586454 Neighboring gene PRKAG2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:151587423-151587923 Neighboring gene MPRA-validated peak6849 silencer Neighboring gene RNA, U6 small nuclear 604, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26875 Neighboring gene uncharacterized LOC105375570 Neighboring gene MPRA-validated peak6850 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biallelic PRKAG2 Truncating Variants Are Associated with Severe Neonatal Cardiomyopathies. Janin A, et al. Circ Genom Precis Med, 2023 Jun. PMID 37013823
  2. Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation. Zhang J, et al. BMC Med Genomics, 2022 Oct 11. PMID 36221081, Free PMC Article
  3. Identification of the pathogenic effects of missense variants causing PRKAG2 cardiomyopathy. Komurcu-Bayrak E, et al. Arch Biochem Biophys, 2022 Sep 30. PMID 35787834
  4. Controversial molecular functions of CBS versus non-CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review. Gong X, et al. Mol Genet Genomic Med, 2022 Jul. PMID 35588295, Free PMC Article
  5. Hypertrophic cardiomyopathy phenocopy (PRKAG2 syndrome) due to p.Arg302Gln mutation. Rodríguez Ortuño J, et al. Med Clin (Barc), 2022 Apr 8. PMID 34656342

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of AMPKgamma2 increases AMPK signaling to augment human T cell metabolism and function.
    Title: Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function.
  2. Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG.
    Title: Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG.
  3. Biallelic PRKAG2 Truncating Variants Are Associated with Severe Neonatal Cardiomyopathies.
    Title: Biallelic PRKAG2 Truncating Variants Are Associated with Severe Neonatal Cardiomyopathies.
  4. Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation.
    Title: Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation.
  5. Controversial molecular functions of CBS versus non-CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review.
    Title: Controversial molecular functions of CBS versus non-CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review.
  6. Identification of the pathogenic effects of missense variants causing PRKAG2 cardiomyopathy.
    Title: Identification of the pathogenic effects of missense variants causing PRKAG2 cardiomyopathy.
  7. Hypertrophic cardiomyopathy phenocopy (PRKAG2 syndrome) due to p.Arg302Gln mutation.", trans "Fenocopia de miocardiopatia hipertrofica (sindrome de PRKAG2) debido a la mutacion P.Arg302.Gln.
    Title: Hypertrophic cardiomyopathy phenocopy (PRKAG2 syndrome) due to p.Arg302Gln mutation.
  8. CARS senses cysteine deprivation to activate AMPK for cell survival.
    Title: CARS senses cysteine deprivation to activate AMPK for cell survival.
  9. Familial Atrial Enlargement, Conduction Disorder and Symmetric Cardiac Hypertrophy Are Early Signs of PRKAG2 R302Q.
    Title: Familial Atrial Enlargement, Conduction Disorder and Symmetric Cardiac Hypertrophy Are Early Signs of PRKAG2 R302Q.
  10. PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-beta Accumulation in the Alzheimer's Disease Brain.
    Title: PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer's Disease Brain.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in PRKAG2 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Hypertrophic cardiomyopathy 6
MedGen: C1833236 OMIM: 600858 GeneReviews: Hypertrophic Cardiomyopathy Overview
Compare labs
Lethal congenital glycogen storage disease of heart
MedGen: C1849813 OMIM: 261740 GeneReviews: Not available
Compare labs
Wolff-Parkinson-White pattern
MedGen: C0043202 OMIM: 194200 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2015-11-05)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2015-11-05)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder.
EBI GWAS Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
EBI GWAS Catalog
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
matrix gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed
gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP-dependent protein kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphorylase kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of catalytic activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fatty acid oxidation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of glucose import TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular space HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase subunit gamma-2
Names
AMPK subunit gamma-2
epididymis secretory sperm binding protein
protein kinase, AMP-activated, gamma 2 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007486.2 RefSeqGene

    Range
    5117..326105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_430

mRNA and Protein(s)

  1. NM_001040633.2 → NP_001035723.1  5'-AMP-activated protein kinase subunit gamma-2 isoform c

    See identical proteins and their annotated locations for NP_001035723.1

    Status: REVIEWED

    Source sequence(s)
    BC020540, BC068598, DA084454, DA187928, DA697901
    Consensus CDS
    CCDS43683.1
    UniProtKB/TrEMBL
    A0A384MDZ2
    Related
    ENSP00000376549.2, ENST00000392801.6
    Conserved Domains (3) summary
    PHA03307
    Location:2 → 177
    PHA03307; transcriptional regulator ICP4; Provisional
    cd04618
    Location:225 → 362
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:388 → 511
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  2. NM_001304527.2 → NP_001291456.1  5'-AMP-activated protein kinase subunit gamma-2 isoform d

    See identical proteins and their annotated locations for NP_001291456.1

    Status: REVIEWED

    Source sequence(s)
    AK301123, BC020540
    Consensus CDS
    CCDS94236.1
    UniProtKB/TrEMBL
    B7Z6X8, E9PGP6
    Related
    ENSP00000419577.2, ENST00000492843.6
    Conserved Domains (2) summary
    cd04618
    Location:144 → 281
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:307 → 430
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  3. NM_001304531.2 → NP_001291460.1  5'-AMP-activated protein kinase subunit gamma-2 isoform b

    See identical proteins and their annotated locations for NP_001291460.1

    Status: REVIEWED

    Source sequence(s)
    AC006358, AW664063, BC020540, DA151645
    Consensus CDS
    CCDS47752.1
    UniProtKB/Swiss-Prot
    Q9UGJ0
    Related
    ENSP00000419493.2, ENST00000476632.2
    Conserved Domains (2) summary
    cd04618
    Location:28 → 165
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:191 → 314
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  4. NM_001363698.2 → NP_001350627.1  5'-AMP-activated protein kinase subunit gamma-2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966
    UniProtKB/TrEMBL
    B7Z6X8
    Conserved Domains (2) summary
    cd04618
    Location:145 → 282
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:308 → 431
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  5. NM_001407021.1 → NP_001393950.1  5'-AMP-activated protein kinase subunit gamma-2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583

  6. NM_001407022.1 → NP_001393951.1  5'-AMP-activated protein kinase subunit gamma-2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583

  7. NM_001407023.1 → NP_001393952.1  5'-AMP-activated protein kinase subunit gamma-2 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583
    UniProtKB/TrEMBL
    A0A494C155
    Related
    ENSP00000498886.2, ENST00000652321.2

  8. NM_001407024.1 → NP_001393953.1  5'-AMP-activated protein kinase subunit gamma-2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583
    UniProtKB/TrEMBL
    A0A384MDZ2
    Related
    ENSP00000498796.1, ENST00000651764.1

  9. NM_001407026.1 → NP_001393955.1  5'-AMP-activated protein kinase subunit gamma-2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583
    UniProtKB/TrEMBL
    A0A494C1K7
    Related
    ENSP00000499111.1, ENST00000652047.1

  10. NM_001407027.1 → NP_001393956.1  5'-AMP-activated protein kinase subunit gamma-2 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583
    UniProtKB/TrEMBL
    A0A494C1K7

  11. NM_001407028.1 → NP_001393957.1  5'-AMP-activated protein kinase subunit gamma-2 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  12. NM_001407029.1 → NP_001393958.1  5'-AMP-activated protein kinase subunit gamma-2 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  13. NM_001407030.1 → NP_001393959.1  5'-AMP-activated protein kinase subunit gamma-2 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC006966, AC074257, AC093583

  14. NM_001407031.1 → NP_001393960.1  5'-AMP-activated protein kinase subunit gamma-2 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC006966, AC074257, AC093583

  15. NM_001407032.1 → NP_001393961.1  5'-AMP-activated protein kinase subunit gamma-2 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257

  16. NM_001407033.1 → NP_001393962.1  5'-AMP-activated protein kinase subunit gamma-2 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966, AC074257, AC093583

  17. NM_001407034.1 → NP_001393963.1  5'-AMP-activated protein kinase subunit gamma-2 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  18. NM_001407035.1 → NP_001393964.1  5'-AMP-activated protein kinase subunit gamma-2 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  19. NM_001407036.1 → NP_001393965.1  5'-AMP-activated protein kinase subunit gamma-2 isoform q

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  20. NM_001407037.1 → NP_001393966.1  5'-AMP-activated protein kinase subunit gamma-2 isoform r

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  21. NM_001407038.1 → NP_001393967.1  5'-AMP-activated protein kinase subunit gamma-2 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  22. NM_001407039.1 → NP_001393968.1  5'-AMP-activated protein kinase subunit gamma-2 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  23. NM_001407040.1 → NP_001393969.1  5'-AMP-activated protein kinase subunit gamma-2 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC006358, AC006966

  24. NM_016203.4 → NP_057287.2  5'-AMP-activated protein kinase subunit gamma-2 isoform a

    See identical proteins and their annotated locations for NP_057287.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a, also referred to as PRKAG2-a).
    Source sequence(s)
    AJ249976, BC020540, DA123009
    Consensus CDS
    CCDS5928.1
    UniProtKB/Swiss-Prot
    Q53Y07, Q6NUI0, Q75MP4, Q9NUZ9, Q9UDN8, Q9UGJ0, Q9ULX8
    UniProtKB/TrEMBL
    A0A090N8Q6
    Related
    ENSP00000287878.3, ENST00000287878.9
    Conserved Domains (3) summary
    PHA03307
    Location:46 → 221
    PHA03307; transcriptional regulator ICP4; Provisional
    cd04618
    Location:269 → 406
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:432 → 555
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

  25. NM_024429.2 → NP_077747.1  5'-AMP-activated protein kinase subunit gamma-2 isoform b

    See identical proteins and their annotated locations for NP_077747.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) contains a distinct 5' UTR and lacks a large in-frame portion of the 5' coding region, compared to variant a. The resulting isoform (b, also referred to as PRKAG2-b) has a much shorter N-terminus when compared to isoform a. Variants b and e encode the same isoform (b).
    Source sequence(s)
    AK001887, BC020540
    Consensus CDS
    CCDS47752.1
    UniProtKB/Swiss-Prot
    Q9UGJ0
    Related
    ENSP00000387386.2, ENST00000418337.6
    Conserved Domains (2) summary
    cd04618
    Location:28 → 165
    CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
    cd04641
    Location:191 → 314
    CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    151556127..151877115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420448.1 → XP_047276404.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

  2. XM_011516284.2 → XP_011514586.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

    Conserved Domains (3) summary
    COG0517
    Location:354 → 474
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:273 → 402
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:429 → 548
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  3. XM_011516282.2 → XP_011514584.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

    Conserved Domains (3) summary
    COG0517
    Location:354 → 474
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:273 → 402
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:429 → 548
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  4. XM_011516283.2 → XP_011514585.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

    Conserved Domains (3) summary
    COG0517
    Location:355 → 475
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:274 → 403
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:430 → 549
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  5. XM_006716021.3 → XP_006716084.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

    Conserved Domains (3) summary
    COG0517
    Location:355 → 475
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:274 → 403
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:430 → 549
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

  6. XM_047420450.1 → XP_047276406.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

    UniProtKB/TrEMBL
    A0A494C068
    Related
    ENSP00000498384.1, ENST00000650858.1

  7. XM_017012277.3 → XP_016867766.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

    Related
    ENST00000650851.1

  8. XM_011516286.3 → XP_011514588.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

    Conserved Domains (3) summary
    COG0517
    Location:110 → 230
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:29 → 158
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:185 → 304
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    152728656..153049942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358344.1 → XP_054214319.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

  2. XM_054358341.1 → XP_054214316.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

  3. XM_054358340.1 → XP_054214315.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

  4. XM_054358345.1 → XP_054214320.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

  5. XM_054358343.1 → XP_054214318.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

  6. XM_054358342.1 → XP_054214317.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

  7. XM_054358347.1 → XP_054214322.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

    UniProtKB/TrEMBL
    A0A494C068

  8. XM_054358346.1 → XP_054214321.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGJ0.1 GenPept UniProtKB/Swiss-Prot:Q9UGJ0

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