U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PDE4B phosphodiesterase 4B [ Homo sapiens (human) ]

Gene ID: 5142, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PDE4Bprovided by HGNC
Official Full Name
phosphodiesterase 4Bprovided by HGNC
Primary source
HGNC:HGNC:8781
See related
Ensembl:ENSG00000184588 MIM:600127; AllianceGenome:HGNC:8781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE4; PDEIVB
Summary
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PDE4B in Genome Data Viewer
Location:
1p31.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (65792510..66374579)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (65669985..66252011)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (66258193..66840262)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leptin receptor Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1145 Neighboring gene RNA, 7SL, cytoplasmic 854, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:66306741-66307007 Neighboring gene NANOG hESC enhancer GRCh37_chr1:66469251-66469833 Neighboring gene PDE4B antisense RNA 1 Neighboring gene RNA, U4 small nuclear 88, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:66694092-66694275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1152 Neighboring gene Sharpr-MPRA regulatory region 6178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1153 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:66820269-66820769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1160 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:66866019-66867218 Neighboring gene uncharacterized LOC105378776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946325-66946955 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:66946956-66947585 Neighboring gene uncharacterized LOC124904196 Neighboring gene SH3GL interacting endocytic adaptor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recent advances of Phosphodiesterase 4B in cancer. Miao Y, et al. Expert Opin Ther Targets, 2023 Feb. PMID 36803246
  2. Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics. Moreira RG, et al. Clin Transl Sci, 2022 Jun. PMID 35266293, Free PMC Article
  3. Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure. Karam S, et al. Circulation, 2020 Jul 14. PMID 32264695
  4. Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. Meier SM, et al. JAMA Psychiatry, 2019 Sep 1. PMID 31116379, Free PMC Article
  5. Expression and significance of phosphodiesterase 4B gene in peripheral blood of patients with oral lichen planus. Wang C, et al. Int J Dermatol, 2019 Mar. PMID 30229893

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recent advances of Phosphodiesterase 4B in cancer.
    Title: Recent advances of Phosphodiesterase 4B in cancer.
  2. Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop.
    Title: Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop.
  3. Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
    Title: Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
  4. Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics.
    Title: Population genetics of PDE4B (phosphodiesterase-4B) in neglected Native Americans: Implications for cancer pharmacogenetics.
  5. qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.
    Title: qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.
  6. Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease.
    Title: Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease.
  7. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
    Title: circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
  8. Cardiac Overexpression of PDE4B Blunts beta-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
    Title: Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.
  9. Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
    Title: Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
  10. These findings suggest that the disruption of the Myc-PDE4B circuitry can be exploited in the treatment of B cell malignancies.
    Title: Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
EBI GWAS Catalog
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
EBI GWAS Catalog
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes by recruiting cyclic nucleoside phosphodiesterase 4, resulting in increased susceptibility to HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC126529, DKFZp686F2182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity TAS
Traceable Author Statement
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to epinephrine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neutrophil homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Z disc ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in excitatory synapse IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Names
cAMP-specific phosphodiesterase 4B
dunce-like phosphodiesterase E4
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
NP_001032416.1
NP_001032417.1
NP_001032418.1
NP_001284369.1
NP_001284370.1
NP_001284371.1
NP_002591.2
XP_005270981.1
XP_005270982.1
XP_006710743.1
XP_016856934.2
XP_047278357.1
XP_054192935.1
XP_054192936.1
XP_054192937.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029038.1 RefSeqGene

    Range
    5386..587065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001037339.2 → NP_001032416.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 2

    See identical proteins and their annotated locations for NP_001032416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (2, also known as PDE4B2 or PDE32) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AW519027, BC036108, DC399916, L12686, M97515
    Consensus CDS
    CCDS30743.1
    UniProtKB/TrEMBL
    B4DG71
    Related
    ENSP00000360084.5, ENST00000371045.9
    Conserved Domains (1) summary
    pfam00233
    Location:233 → 470
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001037340.3 → NP_001032417.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 3

    See identical proteins and their annotated locations for NP_001032417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (3, also known as PDE4B3) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AB209081, BC036108, BC101480, L12686
    Consensus CDS
    CCDS30742.1
    UniProtKB/TrEMBL
    Q59GM8
    Related
    ENSP00000392947.2, ENST00000423207.6
    Conserved Domains (1) summary
    pfam00233
    Location:390 → 631
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_001037341.2 → NP_001032418.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

    See identical proteins and their annotated locations for NP_001032418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR, compared to variant a. Both variants a and d encode the same isoform (1, also known as PDE4B1 or Tm72).
    Source sequence(s)
    AW519027, BC046161, BC071607, BC101480, DA103627
    Consensus CDS
    CCDS632.1
    UniProtKB/Swiss-Prot
    A5YW33, O15443, Q07343, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
    UniProtKB/TrEMBL
    X5DNX5, X5DR82
    Related
    ENSP00000332116.4, ENST00000329654.8
    Conserved Domains (1) summary
    pfam00233
    Location:405 → 646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. NM_001297440.2 → NP_001284369.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) differs in the 5' UTR and lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    BC036108, CR749667, DA103627, L12686, M97515
    UniProtKB/TrEMBL
    X5DR82
    Conserved Domains (2) summary
    pfam00233
    Location:313 → 553
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:74 → 189
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. NM_001297441.1 → NP_001284370.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR and contains multiple differences in the 5' coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AL357273, AL590783, AW519027, BC036108, BF513098, KJ534917, L12686, M97515
    UniProtKB/TrEMBL
    X5DR82
    Conserved Domains (1) summary
    pfam00233
    Location:330 → 571
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. NM_001297442.2 → NP_001284371.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

    See identical proteins and their annotated locations for NP_001284371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6, also known as PDE4B5) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AK290206, BC036108, L12686, M97515
    Consensus CDS
    CCDS72802.1
    UniProtKB/TrEMBL
    B4DG71
    Related
    ENSP00000432592.1, ENST00000480109.2
    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. NM_002600.4 → NP_002591.2  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

    See identical proteins and their annotated locations for NP_002591.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes the longest isoform (1, also referred to as PDE4B1 or Tm72). Both variants a and d encode the same isoform.
    Source sequence(s)
    AA206316, AA453531, AL513493, BC046161, CN268011, DA126733, L20966
    Consensus CDS
    CCDS632.1
    UniProtKB/Swiss-Prot
    A5YW33, O15443, Q07343, Q13945, Q5TEK4, Q5TEK5, Q5TEK6
    UniProtKB/TrEMBL
    X5DNX5, X5DR82
    Related
    ENSP00000342637.4, ENST00000341517.9
    Conserved Domains (1) summary
    pfam00233
    Location:405 → 646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    65792510..66374579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422401.1 → XP_047278357.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

  2. XM_017001445.2 → XP_016856934.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

  3. XM_005270925.3 → XP_005270982.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    See identical proteins and their annotated locations for XP_005270982.1

    UniProtKB/TrEMBL
    B4DG71
    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_006710680.4 → XP_006710743.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    UniProtKB/TrEMBL
    B4DG71
    Conserved Domains (1) summary
    pfam00233
    Location:200 → 437
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_005270924.4 → XP_005270981.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    See identical proteins and their annotated locations for XP_005270981.1

    UniProtKB/TrEMBL
    B4DG71
    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    65669985..66252011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336960.1 → XP_054192935.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

  2. XM_054336961.1 → XP_054192936.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

  3. XM_054336962.1 → XP_054192937.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07343.1 GenPept UniProtKB/Swiss-Prot:Q07343

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous