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TAOK3 TAO kinase 3 [ Homo sapiens (human) ]

Gene ID: 51347, updated on 7-Apr-2024

Summary

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Official Symbol
TAOK3provided by HGNC
Official Full Name
TAO kinase 3provided by HGNC
Primary source
HGNC:HGNC:18133
See related
Ensembl:ENSG00000135090 MIM:616711; AllianceGenome:HGNC:18133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPK; JIK; hKFC-A; MAP3K18
Summary
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in brain (RPKM 12.0), prostate (RPKM 9.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q24.23
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118149801..118372907, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118137047..118360176, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118587606..118810712, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr12:118557876-118558588 and GRCh37_chr12:118558589-118559300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560014-118560725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560726-118561438 Neighboring gene Sharpr-MPRA regulatory region 10186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118564319-118564855 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118573724-118574224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4923 Neighboring gene MPRA-validated peak1994 silencer Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7107 Neighboring gene Sharpr-MPRA regulatory region 13893 Neighboring gene NANOG hESC enhancer GRCh37_chr12:118666512-118667013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7109 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7110 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118778991-118779218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7111 Neighboring gene uncharacterized LOC124903031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118814415-118814915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7112 Neighboring gene SDS3 homolog, SIN3A corepressor complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STE20-type kinase TAOK3 regulates hepatic lipid partitioning. Xia Y, et al. Mol Metab, 2021 Dec. PMID 34634521, Free PMC Article
  2. Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-ÎşB signaling pathway. Lai TC, et al. Cell Commun Signal, 2020 Oct 21. PMID 33087151, Free PMC Article
  3. TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK. Ormonde JVS, et al. J Immunol, 2018 Dec 1. PMID 30373850
  4. Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit. Gutteridge T, et al. J Pain Symptom Manage, 2018 Oct. PMID 30031856
  5. TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate. Komazin-Meredith G, et al. Antiviral Res, 2015 Jul. PMID 25857706, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
    Title: The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
  2. TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.
    Title: TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.
  3. The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice.
    Title: The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice.
  4. STE20-type kinase TAOK3 regulates hepatic lipid partitioning.
    Title: STE20-type kinase TAOK3 regulates hepatic lipid partitioning.
  5. Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-kappaB signaling pathway.
    Title: Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-ÎşB signaling pathway.
  6. Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5alpha Promotes Cancer Invasion and Tumor Growth.
    Title: Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
  7. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
    Title: TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
  8. TAOK3 SNPs (rs1277441 and rs795484) were associated with opioid doses in advanced cancer patients receiving palliative care. The proportions of variant homozygotes (8.2% of patients) and their requirement for higher doses of opioids would appear potentially clinically important and should be validated in further studies.
    Title: Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit.
  9. TAOK3 is a positive regulator of TCR signaling by preventing premature SHP-1-mediated inactivation of LCK
    Title: TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK.
  10. Results show that three CpG loci within FYN were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3.
    Title: Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31808, DKFZp666H245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase TAO3
Names
CTCL-associated antigen HD-CL-09
JNK/SAPK-inhibitory kinase
STE20-like kinase
cutaneous T-cell lymphoma-associated antigen HD-CL-09
dendritic cell-derived protein kinase
jun kinase-inhibitory kinase
kinase from chicken homolog A
thousand and one amino acid protein 3
NP_001333416.1
NP_001333417.1
NP_001333418.1
NP_001333419.1
NP_001333420.1
NP_001333421.1
NP_001333422.1
NP_001333423.1
NP_001333424.1
NP_001333425.1
NP_001333426.1
NP_057365.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051835.1 RefSeqGene

    Range
    5039..228145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346487.2 → NP_001333416.1  serine/threonine-protein kinase TAO3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC026366, AC026367, AC073596
    UniProtKB/TrEMBL
    A8K0J3
    Conserved Domains (1) summary
    cd06633
    Location:2 → 314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

  2. NM_001346488.2 → NP_001333417.1  serine/threonine-protein kinase TAO3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform b.
    Source sequence(s)
    AC026366, AC026367, AC073596
    Consensus CDS
    CCDS9188.1
    UniProtKB/Swiss-Prot
    Q658N1, Q8IUM4, Q9H2K8, Q9HC79, Q9NZM9, Q9UHG7
    UniProtKB/TrEMBL
    A8K0J3
    Conserved Domains (2) summary
    COG0419
    Location:454 → 874
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06633
    Location:2 → 314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

  3. NM_001346489.2 → NP_001333418.1  serine/threonine-protein kinase TAO3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC026366, AF135158, DB165555
    Consensus CDS
    CCDS9188.1
    UniProtKB/Swiss-Prot
    Q658N1, Q8IUM4, Q9H2K8, Q9HC79, Q9NZM9, Q9UHG7
    UniProtKB/TrEMBL
    A8K0J3
    Related
    ENSP00000416374.2, ENST00000419821.6
    Conserved Domains (2) summary
    COG0419
    Location:454 → 874
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06633
    Location:2 → 314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

  4. NM_001346490.2 → NP_001333419.1  serine/threonine-protein kinase TAO3 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC026366, AC026367, AC073596
    UniProtKB/TrEMBL
    A8K0J3
    Conserved Domains (2) summary
    cl21453
    Location:1 → 144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:254 → 720
    Neuromodulin_N; Gap junction protein N-terminal region

  5. NM_001346491.2 → NP_001333420.1  serine/threonine-protein kinase TAO3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform d.
    Source sequence(s)
    AC026366, AC026367, AC073596
    UniProtKB/TrEMBL
    A8K0J3
    Conserved Domains (2) summary
    cl21453
    Location:1 → 144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:245 → 711
    Neuromodulin_N; Gap junction protein N-terminal region

  6. NM_001346492.2 → NP_001333421.1  serine/threonine-protein kinase TAO3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC026366, AC026367, AC073596
    UniProtKB/TrEMBL
    A8K0J3
    Conserved Domains (2) summary
    cl21453
    Location:1 → 144
    PKc_like; Protein Kinases, catalytic domain
    cl26511
    Location:245 → 711
    Neuromodulin_N; Gap junction protein N-terminal region

  7. NM_001346493.2 → NP_001333422.1  serine/threonine-protein kinase TAO3 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC026366, AC026367, AC073596

  8. NM_001346494.2 → NP_001333423.1  serine/threonine-protein kinase TAO3 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform f.
    Source sequence(s)
    AC026366
    Consensus CDS
    CCDS86334.1
    UniProtKB/TrEMBL
    B3KPH9, G3V1Q8
    Related
    ENSP00000443834.1, ENST00000537952.1
    Conserved Domains (2) summary
    PTZ00121
    Location:52 → 421
    PTZ00121; MAEBL; Provisional
    cl39057
    Location:310 → 410
    MS_channel; Mechanosensitive ion channel

  9. NM_001346495.2 → NP_001333424.1  serine/threonine-protein kinase TAO3 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform f.
    Source sequence(s)
    AC026366
    Consensus CDS
    CCDS86334.1
    UniProtKB/TrEMBL
    B3KPH9, G3V1Q8
    Conserved Domains (2) summary
    PTZ00121
    Location:52 → 421
    PTZ00121; MAEBL; Provisional
    cl39057
    Location:310 → 410
    MS_channel; Mechanosensitive ion channel

  10. NM_001346496.2 → NP_001333425.1  serine/threonine-protein kinase TAO3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform g.
    Source sequence(s)
    AC026366
    UniProtKB/TrEMBL
    B3KPH9
    Conserved Domains (2) summary
    PTZ00121
    Location:7 → 387
    PTZ00121; MAEBL; Provisional
    cl39057
    Location:310 → 406
    MS_channel; Mechanosensitive ion channel

  11. NM_001346497.2 → NP_001333426.1  serine/threonine-protein kinase TAO3 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform g.
    Source sequence(s)
    AC026366
    UniProtKB/TrEMBL
    B3KPH9
    Conserved Domains (2) summary
    PTZ00121
    Location:7 → 387
    PTZ00121; MAEBL; Provisional
    cl39057
    Location:310 → 406
    MS_channel; Mechanosensitive ion channel

  12. NM_016281.4 → NP_057365.3  serine/threonine-protein kinase TAO3 isoform b

    See identical proteins and their annotated locations for NP_057365.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 4, encodes isoform b.
    Source sequence(s)
    AA744362, AI057643, AL833460, BC002756, DB066061
    Consensus CDS
    CCDS9188.1
    UniProtKB/Swiss-Prot
    Q658N1, Q8IUM4, Q9H2K8, Q9HC79, Q9NZM9, Q9UHG7
    UniProtKB/TrEMBL
    A8K0J3
    Related
    ENSP00000376317.3, ENST00000392533.8
    Conserved Domains (2) summary
    COG0419
    Location:454 → 874
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06633
    Location:2 → 314
    STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    118149801..118372907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    118137047..118360176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2K8.2 GenPept UniProtKB/Swiss-Prot:Q9H2K8

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