U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IPO11 importin 11 [ Homo sapiens (human) ]

Gene ID: 51194, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
IPO11provided by HGNC
Official Full Name
importin 11provided by HGNC
Primary source
HGNC:HGNC:20628
See related
Ensembl:ENSG00000086200 MIM:610889; AllianceGenome:HGNC:20628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RanBP11
Summary
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Expression
Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IPO11 in Genome Data Viewer
Location:
5q12.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62412763..62628582)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63232336..63448295)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61708590..61924409)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22596 Neighboring gene kinesin family member 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16052 Neighboring gene DIM1 rRNA methyltransferase and ribosome maturation factor Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61791875-61792070 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61864515-61865147 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61865148-61865779 Neighboring gene IPO11-LRRC70 readthrough Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61905853-61905971 Neighboring gene ribosomal protein L35a pseudogene 14 Neighboring gene leucine rich repeat containing 70 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:62013981-62014721 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:62265821-62266321 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62277957-62278458 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62278459-62278958 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:62421058-62421608 Neighboring gene MPRA-validated peak5264 silencer Neighboring gene dedicator of cytokinesis 9 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The nuclear transporter importin-11 regulates the Wnt/β-catenin pathway and acts as a tumor promoter in glioma. Ni H, et al. Int J Biol Macromol, 2021 Apr 15. PMID 33571591
  2. Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival. Zhao J, et al. Oncotarget, 2016 Nov 15. PMID 27689332, Free PMC Article
  3. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Gu Y, et al. Mol Cancer, 2021 Oct 14. PMID 34649567, Free PMC Article
  4. Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians. Zuo L, et al. Am J Med Genet B Neuropsychiatr Genet, 2015 Oct. PMID 26079129, Free PMC Article
  5. Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. Zuo L, et al. Alcohol Clin Exp Res, 2013 May. PMID 23216389, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
    Title: Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.
  2. The nuclear transporter importin-11 regulates the Wnt/beta-catenin pathway and acts as a tumor promoter in glioma.
    Title: The nuclear transporter importin-11 regulates the Wnt/β-catenin pathway and acts as a tumor promoter in glioma.
  3. IPO11 mediates betacatenin nuclear import in a subset of colorectal cancers.
    Title: IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
  4. High IPO11 expression is associated with migration, invasion, and progression of bladder cancer.
    Title: Importin-11 overexpression promotes the migration, invasion, and progression of bladder cancer associated with the deregulation of CDKN1A and THBS1.
  5. IPO11 copy number amplification and importin-11 overexpression are promising biomarkers for predicting the progression and poor prognosis of patients with NMIBC.
    Title: Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent copy number variation in IPO11 and prognostic significance of importin-11 overexpression on poor survival.
  6. IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN.
    Title: Protecting PTEN in the Nucleus.
  7. IPO11-HTR1A is a significant risk gene region for attention deficit hyperactivity disorder in Caucasians.
    Title: Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians.
  8. Data indicate that ubiquitin-conjugating enzyme UBE2E3 and importin 11 (Imp-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (Nrf2) by restricting the transcription factor from partitioning to the mitochondria
    Title: The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Readthrough IPO11-LRRC70

Readthrough gene: IPO11-LRRC70, Included gene: LRRC70

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
importin-11
Names
Ran binding protein 11
imp11
ran-binding protein 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134779.2 → NP_001128251.1  importin-11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF111109, AK302781, BC033776, BM966917
    Consensus CDS
    CCDS47217.1
    UniProtKB/TrEMBL
    F8WDV0
    Related
    ENSP00000386992.3, ENST00000409296.7
    Conserved Domains (3) summary
    COG5657
    Location:50 → 1012
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
    pfam03810
    Location:68 → 140
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:466 → 499
    HEAT; HEAT repeat [structural motif]

  2. NM_016338.5 → NP_057422.3  importin-11 isoform 2

    See identical proteins and their annotated locations for NP_057422.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF111109, BC033776, BM966917, DA473424
    Consensus CDS
    CCDS34167.1
    UniProtKB/Swiss-Prot
    A6NGJ5, B4DZ73, D3DW98, Q8N5R2, Q9NSJ6, Q9NVB1, Q9UI26
    UniProtKB/TrEMBL
    F8WDV0
    Related
    ENSP00000316651.6, ENST00000325324.11
    Conserved Domains (2) summary
    sd00044
    Location:426 → 459
    HEAT; HEAT repeat [structural motif]
    cl27876
    Location:10 → 972
    Cse1; Cse1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    62412763..62628582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    63232336..63448295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UI26.1 GenPept UniProtKB/Swiss-Prot:Q9UI26

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous