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RPL26L1 ribosomal protein L26 like 1 [ Homo sapiens (human) ]

Gene ID: 51121, updated on 7-Apr-2024

Summary

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Official Symbol
RPL26L1provided by HGNC
Official Full Name
ribosomal protein L26 like 1provided by HGNC
Primary source
HGNC:HGNC:17050
See related
Ensembl:ENSG00000037241 AllianceGenome:HGNC:17050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPL26P1
Summary
This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in testis (RPKM 13.8), kidney (RPKM 5.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See RPL26L1 in Genome Data Viewer
Location:
5q35.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172954094..172969771)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173494364..173509843)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172385732..172396774)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901135 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:172276540-172277739 Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:172281789-172282290 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172285332-172285509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172286171-172287171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172290019-172290520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172304495-172305470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172305471-172306446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172328739-172329249 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:172331587-172332786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172341803-172342303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172345389-172345890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172347219-172347863 Neighboring gene microRNA 10523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23649 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172370360-172370531 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:172382074-172383273 Neighboring gene RPL26L1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5956 Neighboring gene inorganic pyrophosphatase 1 pseudogene Neighboring gene ATPase H+ transporting V0 subunit e1 Neighboring gene Sharpr-MPRA regulatory region 12761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172444454-172444997 Neighboring gene Sharpr-MPRA regulatory region 4768 Neighboring gene small nucleolar RNA, H/ACA box 74B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Probing nuclear pore complex architecture with proximity-dependent biotinylation. Kim DI, et al. Proc Natl Acad Sci U S A, 2014 Jun 17. PMID 24927568, Free PMC Article
  2. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Nguyen TV, et al. Mol Cell, 2016 Mar 17. PMID 26990986, Free PMC Article
  3. The molecular mechanics of eukaryotic translation. Kapp LD, et al. Annu Rev Biochem, 2004. PMID 15189156
  4. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy. Iradi MCG, et al. Sci Rep, 2018 Mar 6. PMID 29511296, Free PMC Article
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. Guarani V, et al. Mol Cell Biol, 2014 Mar. PMID 24344204, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ46904

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
ribosomal protein uL24-like
Names
60S ribosomal protein L26-like 1
large ribosomal subunit protein uL24-like 1
ribosomal protein L26 homolog
ribosomal protein L26 pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317980.2 → NP_001304909.1  ribosomal protein uL24-like

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC008429, BC017360, BU193755
    Consensus CDS
    CCDS4382.1
    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000428223.1, ENST00000521476.5
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  2. NM_001317981.2 → NP_001304910.1  ribosomal protein uL24-like

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    BC017360, BI838595
    Consensus CDS
    CCDS4382.1
    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000428177.1, ENST00000519974.5
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  3. NM_001317982.2 → NP_001304911.1  ribosomal protein uL24-like

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC008429, BC017360, BQ278240, BU569345
    Consensus CDS
    CCDS4382.1
    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000430147.1, ENST00000519239.5
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  4. NM_016093.4 → NP_057177.1  ribosomal protein uL24-like

    See identical proteins and their annotated locations for NP_057177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    BC017360, HY015036
    Consensus CDS
    CCDS4382.1
    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Related
    ENSP00000265100.2, ENST00000265100.6
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    172954094..172969771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534565.3 → XP_011532867.1  ribosomal protein uL24-like isoform X1

    See identical proteins and their annotated locations for XP_011532867.1

    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  2. XM_017009520.2 → XP_016865009.1  ribosomal protein uL24-like isoform X1

    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

  3. XM_017009519.3 → XP_016865008.1  ribosomal protein uL24-like isoform X1

    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
    UniProtKB/TrEMBL
    Q6IBH6
    Conserved Domains (2) summary
    PRK05431
    Location:109 → 145
    PRK05431; seryl-tRNA synthetase; Provisional
    pfam16906
    Location:8 → 122
    Ribosomal_L26; Ribosomal proteins L26 eukaryotic, L24P archaeal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    173494364..173509843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352711.1 → XP_054208686.1  ribosomal protein uL24-like isoform X1

    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3

  2. XM_054352712.1 → XP_054208687.1  ribosomal protein uL24-like isoform X1

    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3

  3. XM_054352710.1 → XP_054208685.1  ribosomal protein uL24-like isoform X1

    UniProtKB/Swiss-Prot
    B3KY82, D3DQM0, Q9UNX3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UNX3.1 GenPept UniProtKB/Swiss-Prot:Q9UNX3

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