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PCCA propionyl-CoA carboxylase subunit alpha [ Homo sapiens (human) ]

Gene ID: 5095, updated on 3-Apr-2024

Summary

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Official Symbol
PCCAprovided by HGNC
Official Full Name
propionyl-CoA carboxylase subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:8653
See related
Ensembl:ENSG00000175198 MIM:232000; AllianceGenome:HGNC:8653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Expression
Broad expression in kidney (RPKM 11.9), liver (RPKM 5.1) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
13q32.3
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (100089093..100530435)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (99302579..99745721)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (100741347..101182689)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:100732007-100732527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5476 Neighboring gene Sharpr-MPRA regulatory region 14306 Neighboring gene ASNS pseudogene 3 Neighboring gene PCCA divergent transcript Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr13:100781340-100781840 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr13:100781841-100782341 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:100800509-100801160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:100803131-100803672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:100802588-100803130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:100811517-100812018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:100812019-100812518 Neighboring gene ribosomal protein L15 pseudogene 18 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:100849737-100850237 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:100875184-100875695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:100875696-100876206 Neighboring gene uncharacterized LOC105370335 Neighboring gene Sharpr-MPRA regulatory region 7114 Neighboring gene uncharacterized LOC124903201 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:101044561-101045760 Neighboring gene uncharacterized LOC107984574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:101145271-101145771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:101144770-101145270 Neighboring gene PCCA antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101154747-101155384 Neighboring gene RPL7L1 pseudogene 6 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101161543-101162161 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:101162162-101162780 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101162781-101163398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101169316-101170040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101171491-101172156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101177366-101177888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101182623-101183592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101196750-101197473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:101197474-101198196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101198945-101199623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:101199624-101200301 Neighboring gene ribosomal protein S26 pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5477 Neighboring gene gamma-glutamylamine cyclotransferase Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical characteristics and mutation analysis of propionic acidemia in Thailand. Vatanavicharn N, et al. World J Pediatr, 2014 Feb. PMID 24464666
  2. Propionic acidemia associated with visual hallucinations. Shuaib T, et al. J Child Neurol, 2012 Jun. PMID 22156789
  3. High frequency of large genomic deletions in the PCCA gene causing propionic acidemia. Desviat LR, et al. Mol Genet Metab, 2009 Apr. PMID 19157943
  4. Characterization of four variant forms of human propionyl-CoA carboxylase expressed in Escherichia coli. Jiang H, et al. J Biol Chem, 2005 Jul 29. PMID 15890657
  5. Functional characterization of PCCA mutations causing propionic acidemia. Clavero S, et al. Biochim Biophys Acta, 2002 Nov 20. PMID 12385775

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer.
    Title: Differentially expressed genes PCCA, ECHS1, and HADH are potential prognostic biomarkers for gastric cancer.
  2. A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.
    Title: A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.
  3. Functional Analysis of the PCCA and PCCB Gene Variants Predicted to Affect Splicing.
    Title: Functional Analysis of the PCCA and PCCB Gene Variants Predicted to Affect Splicing.
  4. his work represents a large-scale update on pathogenic mutations in the PCCA and PCCB genes causing Propionic acidemia (PA), and confirms previous reports indicating a major causative role of mutation-induced protein destabilization
    Title: Identification of 34 novel mutations in propionic acidemia: Functional characterization of missense variants and phenotype associations.
  5. The data indicate that amino acid/nucleotide metabolism-related genes OGDH, PPAT and PCCA acquire somatic mutations in microsatellite instability-high gastric cancers and colorectal cancers and that mutational intratumoral heterogeneity may occur in at least some of these tumors.
    Title: Frameshift mutations of OGDH, PPAT and PCCA genes in gastric and colorectal cancers.
  6. The majority of patients had mutations in the PCCA gene (18/25). A total of 26 mutations were noted: 20 in the PCCA gene and 6 in PCCB gene. Seventeen mutations were novel (14 in PCCA and 3 in PCCB). The SNP c.937C>T (p.Arg313Ter), was noted in 9/36 (25%) alleles in the PCCA gene
    Title: Seventeen Novel Mutations in PCCA and PCCB Genes in Indian Propionic Acidemia Patients, and Their Outcomes.
  7. Ten propionic acidemia mutations were confirmed, including 8 affecting the PCCA gene and 2 affecting the PCCB gene
    Title: [Analysis of PCCA and PCCB gene mutations in patients with propionic acidemia].
  8. Two PCCA mutations, c.229C-->T (p.R77W) and c.1262A-->C (p.Q421P), were identified in a PCCA-deficient patient.
    Title: Two frequent mutations associated with the classic form of propionic acidemia in Taiwan.
  9. Mutation analysis of the PCCA gene identified homozygous c.1284+1G>A in patient 1, c.230G>A (p.R77Q) and c.1855C>T (p.R619X) in patient 2, homozygous c.2125T>C (p.S709P) in patient 3, and only one mutant allele, c.231+1G>T in patient 4.
    Title: Clinical characteristics and mutation analysis of propionic acidemia in Thailand.
  10. Thsi study presented that Propionic acidemia(PCCA mutation) associated with visual hallucinations
    Title: Propionic acidemia associated with visual hallucinations.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Propionic acidemia
MedGen: C0268579 OMIM: 606054 GeneReviews: Propionic Acidemia
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EBI GWAS Catalog

Description
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables biotin binding TAS
Traceable Author Statement
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables propionyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables propionyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables propionyl-CoA carboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in branched-chain amino acid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in fatty acid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in short-chain fatty acid catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
propionyl-CoA carboxylase alpha chain, mitochondrial
Names
PCCase alpha subunit
pccA complementation group
propanoyl-CoA:carbon dioxide ligase alpha subunit
propionyl CoA carboxylase, alpha polypeptide
propionyl Coenzyme A carboxylase, alpha polypeptide
propionyl-CoA carboxylase alpha subunit
NP_000273.2
NP_001121164.1
NP_001171475.1
NP_001339534.1
NP_001339535.1
NP_001339536.1
NP_001339537.1
NP_001339538.1
NP_001339539.1
NP_001339540.1
NP_001339541.1
XP_011519395.1
XP_016876094.1
XP_016876095.1
XP_016876096.1
XP_016876098.1
XP_016876100.1
XP_016876101.1
XP_016876102.1
XP_016876104.1
XP_016876105.1
XP_047286326.1
XP_047286327.1
XP_047286328.1
XP_047286329.1
XP_047286330.1
XP_047286331.1
XP_047286332.1
XP_047286333.1
XP_047286334.1
XP_054230547.1
XP_054230548.1
XP_054230549.1
XP_054230550.1
XP_054230551.1
XP_054230552.1
XP_054230553.1
XP_054230554.1
XP_054230556.1
XP_054230557.1
XP_054230558.1
XP_054230559.1
XP_054230560.1
XP_054230561.1
XP_054230562.1
XP_054230563.1
XP_054230564.1
XP_054230565.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008768.1 RefSeqGene

    Range
    5011..446353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000282.4 → NP_000273.2  propionyl-CoA carboxylase alpha chain, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_000273.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF385926, BC000140
    Consensus CDS
    CCDS9496.2
    UniProtKB/Swiss-Prot
    B4DKY8, B4DPF9, C9JPQ8, P05165, Q15979, Q8WXQ7
    UniProtKB/TrEMBL
    B2RDE0
    Related
    ENSP00000365462.1, ENST00000376285.6
    Conserved Domains (5) summary
    cd06850
    Location:661 → 727
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:397 → 504
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:63 → 728
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:63 → 171
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:176 → 383
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. NM_001127692.3 → NP_001121164.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to NM_000282.3.
    Source sequence(s)
    AF385926, BC000140, DA781564
    Consensus CDS
    CCDS45065.1
    UniProtKB/TrEMBL
    B2RDE0
    Related
    ENSP00000365463.4, ENST00000376286.8
    Conserved Domains (5) summary
    cd06850
    Location:635 → 701
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:371 → 478
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:37 → 702
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:37 → 145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:150 → 357
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  3. NM_001178004.2 → NP_001171475.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter compared to isoform a.
    Source sequence(s)
    AK298318, AL356575, CB851764
    Consensus CDS
    CCDS53878.1
    UniProtKB/TrEMBL
    B2RDE0
    Related
    ENSP00000365456.3, ENST00000376279.7
    Conserved Domains (5) summary
    cd06850
    Location:631 → 680
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:397 → 504
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:63 → 681
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:63 → 171
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:176 → 383
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  4. NM_001352605.2 → NP_001339534.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    UniProtKB/TrEMBL
    B2RDE0
    Conserved Domains (1) summary
    COG4770
    Location:63 → 710
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]

  5. NM_001352606.2 → NP_001339535.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    UniProtKB/TrEMBL
    A0A1B0GU58
    Related
    ENSP00000489974.1, ENST00000637657.1
    Conserved Domains (1) summary
    cl27361
    Location:63 → 680
    Biotin_carb_C; Biotin carboxylase C-terminal domain

  6. NM_001352607.2 → NP_001339536.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform f

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    UniProtKB/TrEMBL
    B2RDE0
    Conserved Domains (1) summary
    cl27361
    Location:37 → 655
    Biotin_carb_C; Biotin carboxylase C-terminal domain

  7. NM_001352608.2 → NP_001339537.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform g

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    UniProtKB/TrEMBL
    A0A1B0GU58
    Conserved Domains (1) summary
    cl27361
    Location:37 → 654
    Biotin_carb_C; Biotin carboxylase C-terminal domain

  8. NM_001352609.2 → NP_001339538.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform h precursor

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    UniProtKB/TrEMBL
    B2RDE0
    Conserved Domains (1) summary
    cl27361
    Location:63 → 592
    Biotin_carb_C; Biotin carboxylase C-terminal domain

  9. NM_001352610.2 → NP_001339539.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform i

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    Conserved Domains (1) summary
    cl27361
    Location:1 → 413
    Biotin_carb_C; Biotin carboxylase C-terminal domain

  10. NM_001352611.2 → NP_001339540.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform j

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    Conserved Domains (1) summary
    cl27361
    Location:1 → 395
    Biotin_carb_C; Biotin carboxylase C-terminal domain

  11. NM_001352612.2 → NP_001339541.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform k

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575
    Conserved Domains (1) summary
    cl27361
    Location:1 → 365
    Biotin_carb_C; Biotin carboxylase C-terminal domain

RNA

  1. NR_148027.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575

  2. NR_148028.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575

  3. NR_148029.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575

  4. NR_148030.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575

  5. NR_148031.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136526, AL353697, AL355338, AL356575

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    100089093..100530435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020609.2 → XP_016876098.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X5

    UniProtKB/TrEMBL
    B2RDE0
    Conserved Domains (5) summary
    cd06850
    Location:628 → 694
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:364 → 471
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:30 → 695
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:30 → 138
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:143 → 350
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. XM_047430373.1 → XP_047286329.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X12

  3. XM_017020613.2 → XP_016876102.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X11

    UniProtKB/TrEMBL
    B2RDE0

  4. XM_047430371.1 → XP_047286327.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X7

  5. XM_017020612.2 → XP_016876101.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X9

    UniProtKB/TrEMBL
    B2RDE0

  6. XM_017020611.2 → XP_016876100.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X8

    UniProtKB/TrEMBL
    B2RDE0

  7. XM_011521093.2 → XP_011519395.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X4

    UniProtKB/TrEMBL
    B2RDE0
    Conserved Domains (4) summary
    smart00878
    Location:397 → 504
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK08591
    Location:62 → 504
    PRK08591; acetyl-CoA carboxylase biotin carboxylase subunit; Validated
    pfam00289
    Location:63 → 171
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:176 → 383
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  8. XM_047430372.1 → XP_047286328.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X10

  9. XM_047430375.1 → XP_047286331.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X15

  10. XM_017020607.2 → XP_016876096.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

    UniProtKB/TrEMBL
    B2RDE0

  11. XM_017020605.2 → XP_016876094.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

  12. XM_017020606.2 → XP_016876095.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2

  13. XM_047430374.1 → XP_047286330.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X13

  14. XM_017020615.2 → XP_016876104.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X14

  15. XM_017020616.2 → XP_016876105.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X16

  16. XM_047430377.1 → XP_047286333.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X18

    Related
    ENSP00000490843.1, ENST00000636475.1

  17. XM_047430370.1 → XP_047286326.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X6

  18. XM_047430376.1 → XP_047286332.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X17

  19. XM_047430378.1 → XP_047286334.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X19

RNA

  1. XR_007063681.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    99302579..99745721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374576.1 → XP_054230551.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X5

  2. XM_054374583.1 → XP_054230558.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X12

  3. XM_054374574.1 → XP_054230549.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

  4. XM_054374582.1 → XP_054230557.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X11

  5. XM_054374578.1 → XP_054230553.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X7

  6. XM_054374579.1 → XP_054230554.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X8

  7. XM_054374575.1 → XP_054230550.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X4

  8. XM_054374581.1 → XP_054230556.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X10

  9. XM_054374586.1 → XP_054230561.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X15

  10. XM_054374572.1 → XP_054230547.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

  11. XM_054374573.1 → XP_054230548.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2

  12. XM_054374584.1 → XP_054230559.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X13

  13. XM_054374585.1 → XP_054230560.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X14

  14. XM_054374587.1 → XP_054230562.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X16

  15. XM_054374589.1 → XP_054230564.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X18

  16. XM_054374577.1 → XP_054230552.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X6

  17. XM_054374588.1 → XP_054230563.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X17

  18. XM_054374590.1 → XP_054230565.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X19

RNA

  1. XR_008488765.1 RNA Sequence

  2. XR_008488764.1 RNA Sequence

  3. XR_008488763.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05165.4 GenPept UniProtKB/Swiss-Prot:P05165

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