TAS2R4 taste 2 receptor member 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R4provided by HGNC
Official Full Name: taste 2 receptor member 4provided by HGNC
Primary source: HGNC:HGNC:14911
See related: Ensembl:ENSG00000127364 MIM:604869; AllianceGenome:HGNC:14911
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R4
Summary: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (141776674..141781691)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (143092504..143097521)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (141476474..141481491)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.
Title: Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.
Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor.
Title: Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor.
Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells.
Title: Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells.
In summary, genetic variations in T2R3/4 bitterness receptors may modify the papillary thyroid carcinoma (PTC) risk, and the genetically modified thyroid hormone level by those variations may be linked with the PTC-T2Rs association
Title: Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females.
demonstrate that Lys117, an important CRAC residue, is crucial in the reported cholesterol sensitivity of T2R4. Interestingly, cholesterol sensitivity of T2R4 was observed at quinine concentrations in the lower mM range.
Title: Cholesterol modulates bitter taste receptor function.
This study is the first to show an inhibitory downstream action of a T2R4 agonist on Rac1 function.
Title: Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4.
Data indicate that KLK/R motif in C-terminus performs functional role in bitter taste receptor T2R4 signaling.
Title: The structure-function role of C-terminus in human bitter taste receptor T2R4 signaling.
The antagonist ability of ABA was tested using another T2R4 agonist, yohimbine. Our results suggest that ABA does not inhibit yohimbine-induced T2R4 activity.
Title: Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4.
Data indicate that the itter blockers and agonists share the same orthosteric site in bitter taste receptor T2R4.
Title: Amino acid derivatives as bitter taste receptor (T2R) blockers.
these results show that rhodopsin N-terminal 33 amino acids enhance expression of T2R4 by 2.5-fold and do not cause perturbations in the receptor structure.
Title: Role of rhodopsin N-terminus in structure and function of rhodopsin-bitter taste receptor chimeras.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:494134

TAS2R4__5202 (e-PCR)
- UniSTS:466505

NoName (e-PCR)
- UniSTS:480661

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables taste receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 4

Names: candidate taste receptor T2R4; taste receptor, type 2, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.