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SERPINB2 serpin family B member 2 [ Homo sapiens (human) ]

Gene ID: 5055, updated on 3-Apr-2024

Summary

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Official Symbol
SERPINB2provided by HGNC
Official Full Name
serpin family B member 2provided by HGNC
Primary source
HGNC:HGNC:8584
See related
Ensembl:ENSG00000197632 MIM:173390; AllianceGenome:HGNC:8584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAI; PAI2; PAI-2; PLANH2; HsT1201
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 112.4), skin (RPKM 35.4) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
18q21.33-q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (63887705..63903888)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (64092785..64108961)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61554939..61571122)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904318 Neighboring gene serpin family B member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13469 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61536385-61537584 Neighboring gene uncharacterized LOC124904356 Neighboring gene serpin family B member 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:61607430-61607930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13470 Neighboring gene uncharacterized LOC105372165 Neighboring gene histocompatibility minor serpin domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells. Chen Z, et al. Cells, 2022 Nov 30. PMID 36497110, Free PMC Article
  2. A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone. Cater JH, et al. Cells, 2022 Mar 29. PMID 35406715, Free PMC Article
  3. SERPINB2-its regulation and interplay with aryl hydrocarbon receptor. Brauze D. J Appl Genet, 2021 Feb. PMID 33387293
  4. Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling. Zhang S, et al. Exp Cell Res, 2021 Jan 1. PMID 33227315
  5. Deficiency of plasminogen activator inhibitor-2 results in accelerated tumor growth. Westrick RJ, et al. J Thromb Haemost, 2020 Nov. PMID 32780555, Free PMC Article

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma.
    Title: miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma.
  2. SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells.
    Title: SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells.
  3. Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.
    Title: Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.
  4. A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.
    Title: A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.
  5. HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway.
    Title: HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway.
  6. HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.
    Title: HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.
  7. SERPINB2-its regulation and interplay with aryl hydrocarbon receptor.
    Title: SERPINB2-its regulation and interplay with aryl hydrocarbon receptor.
  8. Deficiency of plasminogen activator inhibitor-2 results in accelerated tumor growth.
    Title: Deficiency of plasminogen activator inhibitor-2 results in accelerated tumor growth.
  9. SERPINB2 and miR-146a/b are coordinately regulated and act in the suppression of psoriasis-associated inflammatory responses in keratinocytes.
    Title: SERPINB2 and miR-146a/b are coordinately regulated and act in the suppression of psoriasis-associated inflammatory responses in keratinocytes.
  10. Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling.
    Title: Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling.
Submit: New GeneRIF Correction See all GeneRIFs (81)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human B cells PubMed
env HIV-1 infection and HIV-1 gp120 treatment of human peripheral blood mononuclear cells result in induction of SerpinB2 and this induction enhances transcription from the HIV-1 LTR PubMed
Tat tat HIV-1 Tat upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human primary T cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of serpin peptidase inhibitor, clade B2 (SERPINB2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in fibrinolysis TAS
Traceable Author Statement
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cornified envelope IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
plasminogen activator inhibitor 2
Names
monocyte Arg-serpin
placental plasminogen activator inhibitor
plasminogen activator inhibitor, type II (arginine-serpin)
plasminogen-activator inhibitor
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
serpin B2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
urokinase inhibitor

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143818.2 → NP_001137290.1  plasminogen activator inhibitor 2

    See identical proteins and their annotated locations for NP_001137290.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072051, CD366374, DA543366, DQ656059
    Consensus CDS
    CCDS11989.1
    UniProtKB/Swiss-Prot
    P05120, Q96E96
    UniProtKB/TrEMBL
    B2R7Y0
    Related
    ENSP00000401645.1, ENST00000457692.5
    Conserved Domains (1) summary
    cd02058
    Location:4 → 415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

  2. NM_002575.3 → NP_002566.1  plasminogen activator inhibitor 2

    See identical proteins and their annotated locations for NP_002566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072051, BC012609, CD366374
    Consensus CDS
    CCDS11989.1
    UniProtKB/Swiss-Prot
    P05120, Q96E96
    UniProtKB/TrEMBL
    B2R7Y0
    Related
    ENSP00000299502.4, ENST00000299502.9
    Conserved Domains (1) summary
    cd02058
    Location:4 → 415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    63887705..63903888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451192.2 → XP_024306960.1  plasminogen activator inhibitor 2 isoform X1

    UniProtKB/Swiss-Prot
    P05120, Q96E96
    UniProtKB/TrEMBL
    B2R7Y0
    Conserved Domains (1) summary
    cd02058
    Location:4 → 415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    64092785..64108961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318676.1 → XP_054174651.1  plasminogen activator inhibitor 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05120.2 GenPept UniProtKB/Swiss-Prot:P05120

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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