P2RY2 purinergic receptor P2Y2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: P2RY2provided by HGNC
Official Full Name: purinergic receptor P2Y2provided by HGNC
Primary source: HGNC:HGNC:8541
See related: Ensembl:ENSG00000175591 MIM:600041; AllianceGenome:HGNC:8541
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
Summary: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Expression: Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (73218281..73242427)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (73146472..73170656)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (72929326..72953472)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
Title: The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer.
Title: AKT/GSK-3beta/VEGF signaling is involved in P2RY2 activation-induced the proliferation and metastasis of gastric cancer.
P2Y2R-mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM-1 overexpression in radiotherapy-resistant-triple negative breast cancer cells.
Title: P2Y(2)R‑mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM‑1 overexpression in radiotherapy‑resistant‑triple negative breast cancer cells.
Aberrant Adenosine Triphosphate Release and Impairment of P2Y2-Mediated Signaling in Sarcoglycanopathies.
Title: Aberrant Adenosine Triphosphate Release and Impairment of P2Y2-Mediated Signaling in Sarcoglycanopathies.
Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.
Title: Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.
Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension.
Title: Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension.
Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.
Title: Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2.
Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation.
Title: Autocrine regulation of wound healing by ATP release and P2Y(2) receptor activation.
NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y2R Activation in Breast Cancer Cells.
Title: NLRC4, ASC and Caspase-1 Are Inflammasome Components that Are Mediated by P2Y(2)R Activation in Breast Cancer Cells.
these findings reveal the roles of the P2RY2 in Pancreatic Ductal Adenocarcinoma metabolic reprogramming, suggesting that P2RY2 might be a potential metabolic therapeutic target for Pancreatic Ductal Adenocarcinoma.
Title: Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of body mass index in 23 000 individuals with and without asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156657P2 (e-PCR)
- UniSTS:271420

D11S4331 (e-PCR)
- UniSTS:36765

PMC96855P1 (e-PCR)
- UniSTS:273639

Clone Names

FLJ37408, MGC20088, MGC40010, DKFZp686H09192

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables A1 adenosine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UTP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ATP	TAS Traceable Author Statement more info	PubMed
involved_in intracellular monoatomic ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mucus secretion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: P2Y purinoceptor 2

Names: ATP receptor; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; purinergic receptor P2Y, G-protein coupled, 2; purinoceptor P2Y2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002564.4 → NP_002555.4 P2Y purinoceptor 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AP002761

Consensus CDS

CCDS8219.1

UniProtKB/Swiss-Prot

B2R9W3, P41231, Q96EM8

Related

ENSP00000377222.2, ENST00000393597.7

Conserved Domains (1) summary

cd15373
Location:34 → 317

7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_176071.3 → NP_788085.3 P2Y purinoceptor 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AP002761

Consensus CDS

CCDS8219.1

UniProtKB/Swiss-Prot

B2R9W3, P41231, Q96EM8

Related

ENSP00000377221.2, ENST00000393596.2

Conserved Domains (1) summary

cd15373
Location:34 → 317

7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_176072.3 → NP_788086.3 P2Y purinoceptor 2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AP002761

Consensus CDS

CCDS8219.1

UniProtKB/Swiss-Prot

B2R9W3, P41231, Q96EM8

Related

ENSP00000310305.2, ENST00000311131.6

Conserved Domains (1) summary

cd15373
Location:34 → 317

7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors