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ROR1 receptor tyrosine kinase like orphan receptor 1 [ Homo sapiens (human) ]

Gene ID: 4919, updated on 11-Apr-2024

Summary

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Official Symbol
ROR1provided by HGNC
Official Full Name
receptor tyrosine kinase like orphan receptor 1provided by HGNC
Primary source
HGNC:HGNC:10256
See related
Ensembl:ENSG00000185483 MIM:602336; AllianceGenome:HGNC:10256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTRKR1; dJ537F10.1
Summary
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues See more
Orthologs
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Genomic context

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See ROR1 in Genome Data Viewer
Location:
1p31.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (63774017..64181498)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (63649841..64057220)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64239688..64647181)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378771 Neighboring gene phosphoglucomutase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:64140637-64141138 Neighboring gene RNA, 7SL, cytoplasmic 130, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:64179745-64180246 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:64187597-64188096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:64197420-64197975 Neighboring gene Sharpr-MPRA regulatory region 14006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 952 Neighboring gene Sharpr-MPRA regulatory region 13784 Neighboring gene Sharpr-MPRA regulatory region 321 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:64246221-64246776 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:64260455-64261114 Neighboring gene ribosomal protein L19 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 953 Neighboring gene cofilin 1 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:64371900-64372424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 954 Neighboring gene Sharpr-MPRA regulatory region 8799 Neighboring gene uncharacterized LOC105378772 Neighboring gene RNA, U6 small nuclear 809, pseudogene Neighboring gene ROR1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:64620864-64621414 Neighboring gene uncharacterized LOC105378773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64661738-64662238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:64662239-64662739 Neighboring gene Sharpr-MPRA regulatory region 11272 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:64728314-64729513 Neighboring gene ubiquitin conjugating enzyme E2 U

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells. Ishikawa T, et al. Cancer Sci, 2023 Feb. PMID 36314076, Free PMC Article
  2. ROR1: an orphan becomes apparent. Kipps TJ. Blood, 2022 Oct 6. PMID 35580162, Free PMC Article
  3. Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1). Guarino SR, et al. Acta Crystallogr F Struct Biol Commun, 2022 May 1. PMID 35506763, Free PMC Article
  4. High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia. Ghia EM, et al. Leukemia, 2022 Jun. PMID 35418613, Free PMC Article
  5. Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer. Ma F, et al. Cancer Res, 2022 Apr 15. PMID 35131873, Free PMC Article

See all (129) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ROR1 expression in mature B lymphoid neoplasms by flow cytometry.
    Title: ROR1 expression in mature B lymphoid neoplasms by flow cytometry.
  2. The onco-embryonic antigen ROR1 is a target of chimeric antigen T cells for colorectal cancer.
    Title: The onco-embryonic antigen ROR1 is a target of chimeric antigen T cells for colorectal cancer.
  3. Evaluation of the prognostic significance of receptor tyrosine kinase-like orphan receptor 1 (ROR1) in lung carcinoma and its relation to lymphangiogenesis and epithelial mesenchymal transition.
    Title: Evaluation of the prognostic significance of receptor tyrosine kinase-like orphan receptor 1 (ROR1) in lung carcinoma and its relation to lymphangiogenesis and epithelial mesenchymal transition.
  4. ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-kappaB signaling pathway.
    Title: ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.
  5. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
  6. Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.
    Title: Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.
  7. MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression.
    Title: MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression.
  8. ROR1: an orphan becomes apparent.
    Title: ROR1: an orphan becomes apparent.
  9. High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia.
    Title: High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia.
  10. Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1).
    Title: Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1).
Submit: New GeneRIF Correction See all GeneRIFs (104)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Hearing loss, autosomal recessive 108
MedGen: C4539997 OMIM: 617654 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Wnt receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables coreceptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in astrocyte development IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive tyrosine-protein kinase transmembrane receptor ROR1
Names
neurotrophic tyrosine kinase, receptor-related 1
NP_001077061.1
NP_005003.2
XP_011539828.1
XP_016856865.1
XP_016856866.1
XP_054192774.1
XP_054192775.1
XP_054192776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032801.2 RefSeqGene

    Range
    4999..412480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083592.2 → NP_001077061.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001077061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' UTR and lacks an in-frame portion of the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter C-terminus that lacks a tyrosine kinase catalytic domain, compared to isoform 1.
    Source sequence(s)
    AL137859, AL161742, AL445205, BC080541
    Consensus CDS
    CCDS41344.1
    UniProtKB/Swiss-Prot
    Q01973
    Related
    ENSP00000360121.1, ENST00000371080.5
    Conserved Domains (3) summary
    cd07467
    Location:166 → 307
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:311 → 392
    KR; Kringle domain
    smart00410
    Location:66 → 148
    IG_like; Immunoglobulin like

  2. NM_005012.4 → NP_005003.2  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_005003.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK000776, AK308088, AL137859, AL161742, AL445205, M97675
    Consensus CDS
    CCDS626.1
    UniProtKB/Swiss-Prot
    Q01973, Q5VVX6, Q66K77, Q92776
    UniProtKB/TrEMBL
    A2VCQ3
    Related
    ENSP00000360120.1, ENST00000371079.6
    Conserved Domains (4) summary
    cd07467
    Location:166 → 307
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:311 → 393
    KR; Kringle domain
    smart00410
    Location:66 → 148
    IG_like; Immunoglobulin like
    cd05090
    Location:467 → 749
    PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    63774017..64181498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541526.2 → XP_011539828.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

    See identical proteins and their annotated locations for XP_011539828.1

    UniProtKB/TrEMBL
    A2VCQ3
    Conserved Domains (4) summary
    cd07467
    Location:103 → 244
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:248 → 330
    KR; Kringle domain
    smart00409
    Location:3 → 85
    IG; Immunoglobulin
    cd05090
    Location:404 → 686
    PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

  2. XM_017001377.2 → XP_016856866.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

    UniProtKB/TrEMBL
    A2VCQ3
    Conserved Domains (4) summary
    cd07467
    Location:103 → 244
    CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
    smart00130
    Location:248 → 330
    KR; Kringle domain
    smart00409
    Location:3 → 85
    IG; Immunoglobulin
    cd05090
    Location:404 → 686
    PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

  3. XM_017001376.2 → XP_016856865.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

    UniProtKB/TrEMBL
    A2VCQ3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    63649841..64057220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336800.1 → XP_054192775.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

  2. XM_054336801.1 → XP_054192776.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

  3. XM_054336799.1 → XP_054192774.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01973.2 GenPept UniProtKB/Swiss-Prot:Q01973

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