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ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [ Homo sapiens (human) ]

Gene ID: 489, updated on 11-Apr-2024

Summary

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Official Symbol
ATP2A3provided by HGNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by HGNC
Primary source
HGNC:HGNC:813
See related
Ensembl:ENSG00000074370 MIM:601929; AllianceGenome:HGNC:813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SERCA3
Summary
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 38.6), stomach (RPKM 37.7) and 18 other tissues See more
Orthologs
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Genomic context

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See ATP2A3 in Genome Data Viewer
Location:
17p13.2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3923873..3964437, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3813121..3853682, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3827167..3867731, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3771089-3771590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3771591-3772090 Neighboring gene Sharpr-MPRA regulatory region 11291 Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3791367-3791886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3791887-3792408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3807108-3807786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11528 Neighboring gene purinergic receptor P2X 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:3831158-3832357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3833185-3834129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3844399-3844898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8025 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3856267-3857115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3860613-3861517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8027 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3879079-3879915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3879916-3880751 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3885316-3886231 Neighboring gene long intergenic non-protein coding RNA 1975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3910389-3911356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11531 Neighboring gene zinc finger ZZ-type and EF-hand domain containing 1 Neighboring gene RNA, 5S ribosomal pseudogene 434

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells. Zhang Y, et al. BMC Cancer, 2019 Apr 25. PMID 31023247, Free PMC Article
  2. Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines. Meneses-Morales I, et al. Mol Carcinog, 2019 Jun. PMID 30657210
  3. Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells. Flores-Peredo L, et al. Mol Carcinog, 2017 Feb. PMID 27433831
  4. Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours. Ait-Ghezali L, et al. Neuropathol Appl Neurobiol, 2014 Oct. PMID 24224513
  5. Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence. Gou WF, et al. Oncol Rep, 2014 Jan. PMID 24213720

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
    Title: Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.
  2. Data show that the nucleotide sequence from -280 to -135 position is an ATP2A3 epigenetic regulatory CpG region. SERCA3 mRNA expression is decreased during gastric and colorectal carcinoma development and tumors with high SERCA3 expression are associated with increased overall survival. These results suggest an essential role for SERCA3 in the regulation of cellular identity and growth, through cellular Ca2+ management.
    Title: Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.
  3. This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca(2+) release and trigger ER stress to exert anti-cancer effects.
    Title: Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells.
  4. Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression. The study showed that these factors participated in the increase of ATP2A3 expression during cancer cell differentiation.
    Title: Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells.
  5. Together, these data provide evidence for the interaction of Bcl-2 with SERCA3b in vitro and in cell culture, and for Bcl-2-dependent conformational and functional changes of SERCA3b.
    Title: Inhibition and conformational change of SERCA3b induced by Bcl-2.
  6. ATP2A3 methylation was not altered between patients with type 2 diabetes and healthy men. Moreover, a glucose challenge did not alter ATP2A3 methylation.
    Title: Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.
  7. we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and beta-cells in the pancreas
    Title: Regulation of SERCA pumps expression in diabetes.
  8. Normal choroid plexus epithelial cells express SERCA3 abundantly, SERCA3 expression is strongly decreased in papillomas, and is absent in choroid plexus carcinoma, while expression in hyperplastic epithelium is high, similarly to normal epithelium.
    Title: Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours.
  9. aberrant SERCA3 expression is closely linked to the adenoma-adenocarcinoma sequence and progression of colorectal carcinomas.
    Title: Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.
  10. The Ca2+-ATPase activity in cloned Plasmodiuim falciparum strain D6 protein is higher than in cloned strain W2 protein. The Ca2+-ATPase activity in isolates from malaria patients varied widely.
    Title: Assessment and characterization of Ca2+-ATPase expression in selected isolates and clones of Plasmodium falciparum.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with ATPase, Ca++ transporting, ubiquitous (ATP2A3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type calcium transporter activity TAS
Traceable Author Statement
more info
  
enables calcium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in calcium ion transport from cytosol to endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in negative regulation of receptor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac conduction TAS
Traceable Author Statement
more info
  
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in platelet dense tubular network membrane TAS
Traceable Author Statement
more info
  
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Names
ATPase, Ca(2+)-transporting, ubiquitous
ATPase, Ca++ transporting, ubiquitous
SR Ca(2+)-ATPase 3
adenosine triphosphatase, calcium
calcium pump 3
calcium-translocating P-type ATPase
sarco/endoplasmic reticulum Ca2+ -ATPase
NP_005164.2
NP_777613.1
NP_777614.1
NP_777615.1
NP_777616.1
NP_777617.1
NP_777618.1
XP_011522183.1
XP_011522184.1
XP_011522186.1
XP_011522187.1
XP_011522190.1
XP_011522191.1
XP_011522194.1
XP_047292106.1
XP_047292107.1
XP_047292108.1
XP_047292109.1
XP_054172247.1
XP_054172248.1
XP_054172249.1
XP_054172250.1
XP_054172251.1
XP_054172252.1
XP_054172253.1
XP_054172254.1
XP_054172255.1
XP_054172256.1
XP_054172257.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029041.1 RefSeqGene

    Range
    5006..45570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005173.4 → NP_005164.2  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform a

    See identical proteins and their annotated locations for NP_005164.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AA643105, AC005940, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS45579.1
    UniProtKB/Swiss-Prot
    A8MZG0, D3DTJ8, O60900, O60901, O75501, O75502, Q16115, Q6JHX1, Q8TEX5, Q8TEX6, Q93084
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000380234.3, ENST00000397041.8
    Conserved Domains (1) summary
    cd02083
    Location:5 → 989
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3

  2. NM_174953.3 → NP_777613.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform e

    See identical proteins and their annotated locations for NP_777613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes two additional exons in the 3' coding region but maintains the reading frame, compared to variant 1. Variant 5 encodes isoform e, which is longer than isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458229, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS11042.1
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000353072.3, ENST00000359983.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  3. NM_174954.3 → NP_777614.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform d

    See identical proteins and their annotated locations for NP_777614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes two additional exons in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 4 encodes isoform d, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458228, AK292716, BC035729, Z69881
    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  4. NM_174955.3 → NP_777615.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b

    See identical proteins and their annotated locations for NP_777615.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 2 encodes isoform b, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458228, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS11041.1
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000301387.6, ENST00000352011.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  5. NM_174956.3 → NP_777616.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

    See identical proteins and their annotated locations for NP_777616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an additional exon in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 3 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF458229, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS42234.1
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000312577.7, ENST00000309890.11
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  6. NM_174957.3 → NP_777617.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform f

    See identical proteins and their annotated locations for NP_777617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in frame splice site in the 3' coding region, compared to variant 1. Variant 6 encodes isoform f, which is one aa shorter than isoform a.
    Source sequence(s)
    AA643105, AC005940, AF068220, AK292716, BC035729, Z69881
    Consensus CDS
    CCDS45580.1
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000380236.3, ENST00000397043.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  7. NM_174958.3 → NP_777618.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform c

    See identical proteins and their annotated locations for NP_777618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) includes an additional exon and uses alternate splices in the 3' coding region resulting in a frameshift, compared to variant 1. Variant 7 encodes isoform c, which is longer and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA643105, AC005940, AF068221, AK292716, BC035729
    Consensus CDS
    CCDS42234.1
    UniProtKB/TrEMBL
    A8K9K1
    Related
    ENSP00000380229.3, ENST00000397035.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3923873..3964437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436153.1 → XP_047292109.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9

  2. XM_047436151.1 → XP_047292107.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6

  3. XM_011523885.2 → XP_011522187.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4

    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  4. XM_047436150.1 → XP_047292106.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5

  5. XM_047436152.1 → XP_047292108.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

  6. XM_011523888.3 → XP_011522190.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  7. XM_011523881.3 → XP_011522183.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  8. XM_011523882.3 → XP_011522184.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  9. XM_011523884.4 → XP_011522186.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3

    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  10. XM_011523889.2 → XP_011522191.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8

    UniProtKB/TrEMBL
    A8K9K1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 989
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:784 → 987
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:604 → 712
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 528
    Cation_ATPase; Cation transport ATPase (P-type)

  11. XM_011523892.3 → XP_011522194.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X10

    Conserved Domains (3) summary
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam13246
    Location:419 → 518
    Cation_ATPase; Cation transport ATPase (P-type)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3813121..3853682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316281.1 → XP_054172256.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X9

  2. XM_054316277.1 → XP_054172252.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6

  3. XM_054316275.1 → XP_054172250.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X4

  4. XM_054316276.1 → XP_054172251.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X5

  5. XM_054316279.1 → XP_054172254.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

  6. XM_054316278.1 → XP_054172253.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X7

  7. XM_054316272.1 → XP_054172247.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

  8. XM_054316273.1 → XP_054172248.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

  9. XM_054316274.1 → XP_054172249.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3

  10. XM_054316280.1 → XP_054172255.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X8

  11. XM_054316282.1 → XP_054172257.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93084.3 GenPept UniProtKB/Swiss-Prot:Q93084

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