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NME2 NME/NM23 nucleoside diphosphate kinase 2 [ Homo sapiens (human) ]

Gene ID: 4831, updated on 11-Apr-2024

Summary

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Official Symbol
NME2provided by HGNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 2provided by HGNC
Primary source
HGNC:HGNC:7850
See related
Ensembl:ENSG00000243678 MIM:156491; AllianceGenome:HGNC:7850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Summary
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in colon (RPKM 115.3), fat (RPKM 91.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
17q21.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (51165536..51171744)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (52032848..52039047)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49242897..49249105)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49175960-49176460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12398 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:49198151-49198965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12400 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:49205455-49205678 Neighboring gene MPRA-validated peak2888 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr17:49219886-49220387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49222416-49222916 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:49230233-49231432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49232587-49233118 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:49243725-49244333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8725 Neighboring gene NME1-NME2 readthrough Neighboring gene MPRA-validated peak2890 silencer Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene mbt domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12402 Neighboring gene UTP18 small subunit processome component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12403 Neighboring gene NANOG hESC enhancer GRCh37_chr17:49408132-49408651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:49409544-49410044 Neighboring gene long intergenic non-protein coding RNA 2071

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells. Qi Y, et al. Cell Death Dis, 2021 Oct 9. PMID 34628473, Free PMC Article
  2. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding. Sengupta P, et al. Biochim Biophys Acta Gen Subj, 2020 Sep. PMID 32492501
  3. Nucleoside diphosphate kinase 2 confers acquired 5-fluorouracil resistance in colorectal cancer cells. Wen S, et al. Artif Cells Nanomed Biotechnol, 2018. PMID 29475390
  4. NME2 reduces proliferation, migration and invasion of gastric cancer cells to limit metastasis. Liu YF, et al. PLoS One, 2015. PMID 25700270, Free PMC Article
  5. Inhibition of telomerase activity by NME2: impact on metastasis suppression? Kar A, et al. Naunyn Schmiedebergs Arch Pharmacol, 2015 Feb. PMID 25547372, Free PMC Article

See all (158) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
    Title: Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
  2. Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.
    Title: Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.
  3. Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
    Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
  4. The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
    Title: The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.
  5. Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.
    Title: Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.
  6. NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
    Title: NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.
  7. miR-645 was up-regulated in osteosarcoma tissues and could promote osteosarcoma cell migration through directly inhibiting the tumor suppressor NME2
    Title: MicroRNA-645 promotes metastasis of osteosarcoma via targeting tumor suppressor NM23 nucleoside diphosphate kinase 2.
  8. Study in cultured HUVEC cells demonstrated that the upregulation of ANG2 upon NDPK-B deficiency (siRNA knockdown) is driven by O-GlcNAcylation of FOXO1 and provide evidence for a central role of protein O-GlcNAcylation in NDPK-B associated vascular damage and point to the hexosamine pathway as an important target in retinal vasoregression.
    Title: O-GlcNAcylation of FoxO1 mediates nucleoside diphosphate kinase B deficiency induced endothelial damage.
  9. Study reports that NME2 is an oncogene in osteosarcoma (OS) that is associated with its clinicopathologic features. Downregulation of NME2 could reduce the proliferation of OS cells and arrest the OS cell cycle in the G2/M phase. The deregulation of NME2 enhanced the expression of c-Myc and affected the proliferation of osteosarcoma.
    Title: Nucleoside diphosphate kinase B promotes osteosarcoma proliferation through c-Myc.
  10. NME2 mediates chemoresistance to 5-FU in CRC
    Title: Nucleoside diphosphate kinase 2 confers acquired 5-fluorouracil resistance in colorectal cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of NME/NM23 nucleoside diphosphate kinase 2 (NME2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2212, MGC111212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleoside triphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
NOT located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nucleoside diphosphate kinase B
Names
HEL-S-155an
NDP kinase B
c-myc purine-binding transcription factor PUF
c-myc transcription factor
epididymis secretory sperm binding protein Li 155an
histidine protein kinase NDKB
non-metastatic cells 2, protein (NM23) expressed in
non-metastatic cells 2, protein (NM23B) expressed in
nucleotide diphosphate kinase B
NP_001018147.1
NP_001018148.1
NP_001018149.1
NP_001185611.1
NP_002503.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018137.3 → NP_001018147.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_001018147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    CA307456, CK023920
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000426976.2, ENST00000514264.6
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  2. NM_001018138.1 → NP_001018148.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_001018148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BC002476, BF058708
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000376886.1, ENST00000393190.4
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  3. NM_001018139.2 → NP_001018149.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_001018149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    BM556410
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000426901.1, ENST00000503064.5
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  4. NM_001198682.2 → NP_001185611.1  nucleoside diphosphate kinase B isoform b

    See identical proteins and their annotated locations for NP_001185611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    CB242387, CN267160, DB454073
    Consensus CDS
    CCDS74107.1
    UniProtKB/TrEMBL
    F6XY72
    Related
    ENSP00000376880.4, ENST00000393183.7
    Conserved Domains (1) summary
    cl00335
    Location:5 → 76
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

  5. NM_002512.4 → NP_002503.1  nucleoside diphosphate kinase B isoform a

    See identical proteins and their annotated locations for NP_002503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-4 encode the same isoform.
    Source sequence(s)
    BC095458, BF034471, DB454073
    Consensus CDS
    CCDS11580.1
    UniProtKB/Swiss-Prot
    A8MWA3, O60361, P22392, Q1WM23, Q6LCT6
    UniProtKB/TrEMBL
    Q6FHN3
    Related
    ENSP00000421064.1, ENST00000512737.6
    Conserved Domains (1) summary
    PTZ00093
    Location:3 → 151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    51165536..51171744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    52032848..52039047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22392.1 GenPept UniProtKB/Swiss-Prot:P22392

Gene LinkOut

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