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NKTR natural killer cell triggering receptor [ Homo sapiens (human) ]

Gene ID: 4820, updated on 25-Apr-2024

Summary

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Official Symbol
NKTRprovided by HGNC
Official Full Name
natural killer cell triggering receptorprovided by HGNC
Primary source
HGNC:HGNC:7833
See related
Ensembl:ENSG00000114857 MIM:161565; AllianceGenome:HGNC:7833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p104; CypNK
Summary
This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 22.3), skin (RPKM 14.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3p22.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42600612..42648735)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42618606..42666734)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42642178..42690227)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42574871-42575372 Neighboring gene VIPR1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581415-42581916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42581917-42582416 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:42622926-42623752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19746 Neighboring gene SS18 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14246 Neighboring gene ZBTB47 and NKTR antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42672544-42673392 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:42673393-42674241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:42695163-42695804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14248 Neighboring gene Sharpr-MPRA regulatory region 3469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42700825-42701735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42701736-42702645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42706502-42707002 Neighboring gene uncharacterized LOC124906232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:42708562-42709098 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene RNA, 7SL, cytoplasmic 567, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. Rinfret A, et al. Mol Immunol, 1993 Oct. PMID 8413330
  2. Expression of the NK-TR gene is required for NK-like activity in human T cells. Chambers CA, et al. J Immunol, 1994 Mar 15. PMID 8144875
  3. Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes. Frey JL, et al. J Exp Med, 1991 Dec 1. PMID 1720812, Free PMC Article
  4. A cyclophilin-related protein involved in the function of natural killer cells. Anderson SK, et al. Proc Natl Acad Sci U S A, 1993 Jan 15. PMID 8421688, Free PMC Article
  5. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. Young HA, et al. Genomics, 1993 May. PMID 8314596

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of natural killer-tumor recognition sequence (NKTR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90527, DKFZp686F1754, DKFZp686G0426, DKFZp686J06106, DKFZp686N24126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NK-tumor recognition protein
Names
NK-TR protein
PPIase
natural killer triggering receptor
natural killer-tumor recognition sequence
natural-killer cells cyclophilin-related protein
peptidyl-prolyl cis-trans isomerase NKTR
rotamase
NP_001336053.1
NP_001336054.1
NP_001336055.1
NP_005376.2
XP_006713234.1
XP_016861963.1
XP_024309307.1
XP_047304148.1
XP_047304149.1
XP_047304150.1
XP_047304151.1
XP_047304152.1
XP_047304153.1
XP_054202610.1
XP_054202611.1
XP_054202612.1
XP_054202613.1
XP_054202614.1
XP_054202615.1
XP_054202616.1
XP_054202617.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349124.2 → NP_001336053.1  NK-tumor recognition protein isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC006059, AC092047
    Conserved Domains (1) summary
    cl00197
    Location:7 → 174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  2. NM_001349125.2 → NP_001336054.1  NK-tumor recognition protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c.
    Source sequence(s)
    AC006059, AC092047
    UniProtKB/TrEMBL
    Q6M1B8

  3. NM_001349126.2 → NP_001336055.1  NK-tumor recognition protein isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains two alternate exons and uses two alternate splice junctions compared to variant 3. The resulting isoform (e) is shorter at the N-terminus and lacks a single internal aa compared to isoform c.
    Source sequence(s)
    AC006059, AC092047
    UniProtKB/TrEMBL
    Q6M1B8

  4. NM_005385.4 → NP_005376.2  NK-tumor recognition protein isoform a

    See identical proteins and their annotated locations for NP_005376.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is 1 aa shorter compared to isoform c.
    Source sequence(s)
    AA493639, L04288
    Consensus CDS
    CCDS2702.1
    UniProtKB/Swiss-Prot
    P30414
    Related
    ENSP00000232978.8, ENST00000232978.13
    Conserved Domains (2) summary
    pfam09528
    Location:786 → 1161
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    cl00197
    Location:7 → 174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    42600612..42648735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453539.2 → XP_024309307.1  NK-tumor recognition protein isoform X1

    Conserved Domains (1) summary
    cl00197
    Location:7 → 174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  2. XM_006713171.3 → XP_006713234.1  NK-tumor recognition protein isoform X2

    Conserved Domains (1) summary
    cl00197
    Location:7 → 174
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

  3. XM_017006474.3 → XP_016861963.1  NK-tumor recognition protein isoform X3

  4. XM_047448196.1 → XP_047304152.1  NK-tumor recognition protein isoform X6

  5. XM_047448197.1 → XP_047304153.1  NK-tumor recognition protein isoform X7

  6. XM_047448193.1 → XP_047304149.1  NK-tumor recognition protein isoform X4

  7. XM_047448192.1 → XP_047304148.1  NK-tumor recognition protein isoform X4

  8. XM_047448194.1 → XP_047304150.1  NK-tumor recognition protein isoform X4

  9. XM_047448195.1 → XP_047304151.1  NK-tumor recognition protein isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    42618606..42666734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346635.1 → XP_054202610.1  NK-tumor recognition protein isoform X1

  2. XM_054346636.1 → XP_054202611.1  NK-tumor recognition protein isoform X2

  3. XM_054346637.1 → XP_054202612.1  NK-tumor recognition protein isoform X3

  4. XM_054346641.1 → XP_054202616.1  NK-tumor recognition protein isoform X6

  5. XM_054346642.1 → XP_054202617.1  NK-tumor recognition protein isoform X7

  6. XM_054346639.1 → XP_054202614.1  NK-tumor recognition protein isoform X4

  7. XM_054346638.1 → XP_054202613.1  NK-tumor recognition protein isoform X4

  8. XM_054346640.1 → XP_054202615.1  NK-tumor recognition protein isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012651.1: Suppressed sequence

    Description
    NM_001012651.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30414.2 GenPept UniProtKB/Swiss-Prot:P30414

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