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NFYC nuclear transcription factor Y subunit gamma [ Homo sapiens (human) ]

Gene ID: 4802, updated on 5-Mar-2024

Summary

Official Symbol
NFYCprovided by HGNC
Official Full Name
nuclear transcription factor Y subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:7806
See related
Ensembl:ENSG00000066136 MIM:605344; AllianceGenome:HGNC:7806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A
Summary
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.6), heart (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
1p34.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40691704..40771603)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40560898..40640813)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41157376..41237275)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 730 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:41093974-41095173 Neighboring gene regulating synaptic membrane exocytosis 3 Neighboring gene uncharacterized LOC105378675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41128965-41129622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 852 Neighboring gene NFYC antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 733 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:41174578-41175204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41180095-41180734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 854 Neighboring gene microRNA 30c-1 Neighboring gene microRNA 30e Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41253587-41254086 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:41267963-41268147 Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41279047-41279546 Neighboring gene RNA, 7SL, cytoplasmic 326, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41286429-41286930 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41290219-41291122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41300271-41300796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41305349-41305957 Neighboring gene uncharacterized LOC105378676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 856

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ45775, DKFZp667G242

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CCAAT-binding factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CCAAT-binding factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit gamma
Names
CAAT box DNA-binding protein subunit C
CCAAT binding factor subunit C
CCAAT transcription binding factor subunit gamma
histone H1 transcription factor large subunit 2A
nuclear transcription factor Y subunit C
nuclear transcription factor Y, gamma
transactivator HSM-1
transactivator HSM-1/2
transcription factor NF-Y, C subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142587.2NP_001136059.1  nuclear transcription factor Y subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001136059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) has the same N- and C- termini but lacks an internal segment and one residue near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AB208975, AL354914, D89986, DC391720
    Consensus CDS
    CCDS44121.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000408867.2, ENST00000456393.6
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  2. NM_001142588.2NP_001136060.1  nuclear transcription factor Y subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_001136060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC119677, AK300774, AL354914, D89986, DC391720
    Consensus CDS
    CCDS44120.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000396620.2, ENST00000425457.6
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  3. NM_001142589.2NP_001136061.1  nuclear transcription factor Y subunit gamma isoform 4

    See identical proteins and their annotated locations for NP_001136061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' and 3' coding regions, compared to variant 1. The resulting isoform (4) has the same N- and C- termini but lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AB208975, AK301385, D89986
    Consensus CDS
    CCDS44123.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000408315.2, ENST00000427410.6
    Conserved Domains (1) summary
    COG5208
    Location:1785
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  4. NM_001142590.2NP_001136062.1  nuclear transcription factor Y subunit gamma isoform 5

    See identical proteins and their annotated locations for NP_001136062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate splice pattern in the 5' UTR, lacks an alternate exon in the 3' coding region, and uses an alternate splice site in the central coding region, compared to variant 1. the resulting isoform (5) has the same N- and C- termini but lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC119677, AK127677, AL031289, AL354914, D89986, DC297902
    Consensus CDS
    CCDS44122.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000361737.1, ENST00000372653.5
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  5. NM_001308114.1NP_001295043.1  nuclear transcription factor Y subunit gamma isoform 6

    See identical proteins and their annotated locations for NP_001295043.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice acceptor site in the 3' terminal exon compared to variant 1. The resulting isoform (6) has the same N- and C- termini but contains an additional segment in the 3' coding region, compared to isoform 1.
    Source sequence(s)
    AF191744, AK000346, BP230898, BU634106
    Consensus CDS
    CCDS81305.1
    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    Related
    ENSP00000312617.5, ENST00000308733.9
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  6. NM_001308115.2NP_001295044.1  nuclear transcription factor Y subunit gamma isoform 7

    See identical proteins and their annotated locations for NP_001295044.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks an alternate in-frame exon in the central coding region, and uses an alternate in-frame splice acceptor site in the 3' terminal exon compared to variant 1. The resulting isoform (7) has the same N- and C- termini but lacks a segment in the central coding region, and contains an additional segment in the 3' coding region, compared to isoform 1.
    Source sequence(s)
    AK000346, BP230898, BU634106
    Consensus CDS
    CCDS81306.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000361736.1, ENST00000372652.5
    Conserved Domains (1) summary
    pfam00808
    Location:42105
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  7. NM_014223.5NP_055038.2  nuclear transcription factor Y subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_055038.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has the same N- and C- termini but lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC119677, BC005003, D89986, DC391720
    Consensus CDS
    CCDS455.1
    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000404427.3, ENST00000447388.8
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40691704..40771603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001365.3XP_016856854.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  2. XM_006710661.3XP_006710724.1  nuclear transcription factor Y subunit gamma isoform X2

    See identical proteins and their annotated locations for XP_006710724.1

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    pfam00808
    Location:42105
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  3. XM_047421386.1XP_047277342.1  nuclear transcription factor Y subunit gamma isoform X17

  4. XM_047421368.1XP_047277324.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
  5. XM_047421353.1XP_047277309.1  nuclear transcription factor Y subunit gamma isoform X6

  6. XM_047421376.1XP_047277332.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
  7. XM_047421347.1XP_047277303.1  nuclear transcription factor Y subunit gamma isoform X3

  8. XM_047421359.1XP_047277315.1  nuclear transcription factor Y subunit gamma isoform X10

  9. XM_047421357.1XP_047277313.1  nuclear transcription factor Y subunit gamma isoform X8

  10. XM_047421358.1XP_047277314.1  nuclear transcription factor Y subunit gamma isoform X9

  11. XM_047421389.1XP_047277345.1  nuclear transcription factor Y subunit gamma isoform X19

  12. XM_047421390.1XP_047277346.1  nuclear transcription factor Y subunit gamma isoform X20

  13. XM_047421351.1XP_047277307.1  nuclear transcription factor Y subunit gamma isoform X2

  14. XM_047421348.1XP_047277304.1  nuclear transcription factor Y subunit gamma isoform X4

  15. XM_006710660.4XP_006710723.2  nuclear transcription factor Y subunit gamma isoform X14

    See identical proteins and their annotated locations for XP_006710723.2

    UniProtKB/Swiss-Prot
    Q13952
    Conserved Domains (1) summary
    cl28542
    Location:17123
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  16. XM_047421337.1XP_047277293.1  nuclear transcription factor Y subunit gamma isoform X2

  17. XM_047421384.1XP_047277340.1  nuclear transcription factor Y subunit gamma isoform X15

    Related
    ENSP00000414299.2, ENST00000440226.7
  18. XM_017001369.2XP_016856858.1  nuclear transcription factor Y subunit gamma isoform X15

    UniProtKB/Swiss-Prot
    Q13952
    Related
    ENSP00000361734.1, ENST00000372651.5
    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  19. XM_017001366.3XP_016856855.1  nuclear transcription factor Y subunit gamma isoform X22

  20. XM_047421385.1XP_047277341.1  nuclear transcription factor Y subunit gamma isoform X16

  21. XM_047421391.1XP_047277347.1  nuclear transcription factor Y subunit gamma isoform X21

  22. XM_024447356.2XP_024303124.1  nuclear transcription factor Y subunit gamma isoform X18

    Conserved Domains (1) summary
    cl28542
    Location:87193
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
  23. XM_047421362.1XP_047277318.1  nuclear transcription factor Y subunit gamma isoform X11

  24. XM_047421356.1XP_047277312.1  nuclear transcription factor Y subunit gamma isoform X7

  25. XM_017001364.3XP_016856853.1  nuclear transcription factor Y subunit gamma isoform X12

  26. XM_024447357.1XP_024303125.1  nuclear transcription factor Y subunit gamma isoform X15

    Conserved Domains (1) summary
    COG5208
    Location:17123
    HAP5; CCAAT-binding factor, subunit C [Transcription]
  27. XM_006710658.4XP_006710721.3  nuclear transcription factor Y subunit gamma isoform X5

  28. XM_047421373.1XP_047277329.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
  29. XM_005270895.5XP_005270952.4  nuclear transcription factor Y subunit gamma isoform X1

    Conserved Domains (1) summary
    cl28542
    Location:103209
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40560898..40640813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336774.1XP_054192749.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
  2. XM_054336778.1XP_054192753.1  nuclear transcription factor Y subunit gamma isoform X2

  3. XM_054336782.1XP_054192757.1  nuclear transcription factor Y subunit gamma isoform X17

  4. XM_054336767.1XP_054192742.1  nuclear transcription factor Y subunit gamma isoform X6

  5. XM_054336776.1XP_054192751.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
  6. XM_054336763.1XP_054192738.1  nuclear transcription factor Y subunit gamma isoform X3

  7. XM_054336771.1XP_054192746.1  nuclear transcription factor Y subunit gamma isoform X10

  8. XM_054336769.1XP_054192744.1  nuclear transcription factor Y subunit gamma isoform X8

  9. XM_054336770.1XP_054192745.1  nuclear transcription factor Y subunit gamma isoform X9

  10. XM_054336784.1XP_054192759.1  nuclear transcription factor Y subunit gamma isoform X19

  11. XM_054336785.1XP_054192760.1  nuclear transcription factor Y subunit gamma isoform X20

  12. XM_054336766.1XP_054192741.1  nuclear transcription factor Y subunit gamma isoform X2

  13. XM_054336764.1XP_054192739.1  nuclear transcription factor Y subunit gamma isoform X4

  14. XM_054336777.1XP_054192752.1  nuclear transcription factor Y subunit gamma isoform X14

  15. XM_054336762.1XP_054192737.1  nuclear transcription factor Y subunit gamma isoform X2

  16. XM_054336779.1XP_054192754.1  nuclear transcription factor Y subunit gamma isoform X15

  17. XM_054336781.1XP_054192756.1  nuclear transcription factor Y subunit gamma isoform X15

  18. XM_054336787.1XP_054192762.1  nuclear transcription factor Y subunit gamma isoform X22

  19. XM_054336780.1XP_054192755.1  nuclear transcription factor Y subunit gamma isoform X16

  20. XM_054336786.1XP_054192761.1  nuclear transcription factor Y subunit gamma isoform X21

  21. XM_054336783.1XP_054192758.1  nuclear transcription factor Y subunit gamma isoform X18

  22. XM_054336772.1XP_054192747.1  nuclear transcription factor Y subunit gamma isoform X11

  23. XM_054336768.1XP_054192743.1  nuclear transcription factor Y subunit gamma isoform X7

  24. XM_054336773.1XP_054192748.1  nuclear transcription factor Y subunit gamma isoform X12

  25. XM_054336788.1XP_054192763.1  nuclear transcription factor Y subunit gamma isoform X15

  26. XM_054336765.1XP_054192740.1  nuclear transcription factor Y subunit gamma isoform X5

  27. XM_054336775.1XP_054192750.1  nuclear transcription factor Y subunit gamma isoform X13

    UniProtKB/Swiss-Prot
    B4DUS6, B4DW63, D3DPV9, F8VWM3, Q13952, Q59GY4, Q5T6K8, Q5T6K9, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7
  28. XM_054336761.1XP_054192736.1  nuclear transcription factor Y subunit gamma isoform X1