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MYL6 myosin light chain 6 [ Homo sapiens (human) ]

Gene ID: 4637, updated on 7-Apr-2024

Summary

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Official Symbol
MYL6provided by HGNC
Official Full Name
myosin light chain 6provided by HGNC
Primary source
HGNC:HGNC:7587
See related
Ensembl:ENSG00000092841 MIM:609931; AllianceGenome:HGNC:7587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM
Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 771.0), endometrium (RPKM 608.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56158359..56161579)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56125971..56129191)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56552143..56555363)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56521723-56522384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6475 Neighboring gene extended synaptotagmin 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:56536437-56537636 Neighboring gene uncharacterized LOC124902943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6476 Neighboring gene uncharacterized LOC124902942 Neighboring gene MYL6B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4547 Neighboring gene myosin light chain 6B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56554412-56555034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56555035-56555655 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6480 Neighboring gene tRNA-Ser (anticodon CGA) 4-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells. Watanabe M, et al. J Smooth Muscle Res, 2001 Feb. PMID 11436981
  2. The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways. Lenz S, et al. J Biol Chem, 1989 May 25. PMID 2722814
  3. The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition. Komiyama M, et al. J Cell Sci, 1996 Aug. PMID 8856505
  4. Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA. Bora PS, et al. Genomics, 1994 Jan 1. PMID 8188229
  5. Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies. Fu ZY, et al. Acta Biochim Biophys Sin (Shanghai), 2006 Sep. PMID 16953301

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6) in the nucleoli of Jurkat T-cells PubMed
tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed
Vpr vpr HIV-1 Vpr upregulates MYL6 in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of muscle IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle filament sliding TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal muscle tissue development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex TAS
Traceable Author Statement
more info
 PubMed 
part_of unconventional myosin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in vesicle HDA PubMed 

General protein information

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Preferred Names
myosin light polypeptide 6
Names
17 kDa myosin light chain
myosin light chain A3
myosin light chain alkali 3
myosin, light chain 6, alkali, smooth muscle and non-muscle
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029223.1 RefSeqGene

    Range
    5099..8319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021019.5 → NP_066299.2  myosin light polypeptide 6 isoform 1

    See identical proteins and their annotated locations for NP_066299.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), which is the major non-muscle transcript, represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    BC017455, BG283793, CA427580
    Consensus CDS
    CCDS8906.1
    UniProtKB/Swiss-Prot
    P16475, P24572, P24573, P60660, Q12790, Q561V9, Q6IAZ0, Q6IPY5
    UniProtKB/TrEMBL
    J3KND3
    Related
    ENSP00000446955.2, ENST00000550697.6
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 150
    PTZ00184; calmodulin; Provisional

  2. NM_079423.4 → NP_524147.2  myosin light polypeptide 6 isoform 2

    See identical proteins and their annotated locations for NP_524147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) is the same length as isoform 1, but the proteins differ in their C-terminal sequences.
    Source sequence(s)
    BC093066, BG283793, CA427580
    Consensus CDS
    CCDS31834.1
    UniProtKB/TrEMBL
    G8JLA2
    Related
    ENSP00000446714.1, ENST00000547649.5
    Conserved Domains (1) summary
    PTZ00184
    Location:5 → 149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56158359..56161579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56125971..56129191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_079425.1: Suppressed sequence

    Description
    NM_079425.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein is not supported by current protein homology data.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60660.2 GenPept UniProtKB/Swiss-Prot:P60660

Gene LinkOut

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