MT1G metallothionein 1G [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT1Gprovided by HGNC
Official Full Name: metallothionein 1Gprovided by HGNC
Primary source: HGNC:HGNC:7399
See related: Ensembl:ENSG00000125144 MIM:156353; AllianceGenome:HGNC:7399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT1; MT1K
Summary: Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney (RPKM 963.2), thyroid (RPKM 736.8) and 7 other tissues See more
Orthologs: all
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56666730..56668065, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62461707..62463042, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56700642..56701977, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MT1G Regulates c-MYC/P53 Signal to Inhibit Proliferation, Invasion and Migration and Promote Apoptosis in Colon Cancer Cells.
Title: MT1G Regulates c-MYC/P53 Signal to Inhibit Proliferation, Invasion and Migration and Promote Apoptosis in Colon Cancer Cells.
The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity.
Title: The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity.
Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-kappaB inhibition.
Title: Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-κB inhibition.
Upregulation of Metallothionein-1G Accelerates G1/S Transition in the Growth Phase of Acute Promyelocytic Leukemia NB4 Cells.
Title: Upregulation of Metallothionein-1G Accelerates G1/S Transition in the Growth Phase of Acute Promyelocytic Leukemia NB4 Cells.
Multivariate analysis indicated that RUNX3 and CDH1 promoter methylation were independent prognostic factors for overall survival (P = 0.03 and 0.04; respectively), while DAPK1, RUNX3 and MT1G PM were independent prognostic factors for disease free survival.
Title: The prognostic impact of hypermethylation for a panel of tumor suppressor genes and cell of origin subtype on diffuse large B-cell lymphoma.
In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression
Title: DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
These findings indicate that MT1 constitute a biomarker adapted for exploring the impact of sorafenib on the redox metabolism of cancer cells.
Title: Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
A new tumor-suppressor activity of MT1G in colorectal cancer cells.MT1G role in cell differentiation.
Title: Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells.
PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation
Title: A PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation.
MT1G was down-regulated in renal cell carcinogenesis.
Title: An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH75829 (e-PCR)
- UniSTS:87831

D16S3240 (e-PCR)
- UniSTS:2114

RH16366 (e-PCR)
- UniSTS:79519

SHGC-35166 (e-PCR)
- UniSTS:19164

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte activation	NAS Non-traceable Author Statement more info	PubMed
involved_in monocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of growth	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metallothionein-1G

Names: MT-1G; MT-1K; MT-IG; metallothionein-1K; metallothionein-IG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301267.2 → NP_001288196.1 metallothionein-1G isoform 2

See identical proteins and their annotated locations for NP_001288196.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is one aa longer than isoform 1.

Source sequence(s)

AC026461, BC020757, BM817643

Consensus CDS

CCDS76873.1

UniProtKB/Swiss-Prot

P13640, P80296

Related

ENSP00000369139.4, ENST00000379811.4

Conserved Domains (1) summary

pfam00131
Location:9 → 62

Metallothio; Metallothionein
NM_005950.3 → NP_005941.1 metallothionein-1G isoform 1

See identical proteins and their annotated locations for NP_005941.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AC026461, BC020757, BM817643, CD175975

Consensus CDS

CCDS10766.1

UniProtKB/TrEMBL

Q8TE66

Related

ENSP00000391397.2, ENST00000444837.6

Conserved Domains (1) summary

pfam00131
Location:5 → 61

Metallothio; Metallothionein