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MPST mercaptopyruvate sulfurtransferase [ Homo sapiens (human) ]

Gene ID: 4357, updated on 3-Apr-2024

Summary

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Official Symbol
MPSTprovided by HGNC
Official Full Name
mercaptopyruvate sulfurtransferaseprovided by HGNC
Primary source
HGNC:HGNC:7223
See related
Ensembl:ENSG00000128309 MIM:602496; AllianceGenome:HGNC:7223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST; TST2; TUM1
Summary
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 33.5), liver (RPKM 30.3) and 25 other tissues See more
Orthologs
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Genomic context

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See MPST in Genome Data Viewer
Location:
22q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37019742..37029815)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (37479341..37489414)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37415783..37425856)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ39582-like Neighboring gene CRISPRi-validated cis-regulatory element chr22.1656 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1657 Neighboring gene ciliary microtubule inner protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37408066-37408566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37408567-37409067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37414031-37415006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:37415035-37415536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13675 Neighboring gene thiosulfate sulfurtransferase Neighboring gene uncharacterized LOC112268295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37428845-37429362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:37429455-37430120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37439765-37440678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37447950-37448667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:37448668-37449384 Neighboring gene RN7SK pseudogene 214 Neighboring gene potassium channel tetramerization domain containing 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 3-Mercaptopyruvate sulfur transferase is a protein persulfidase. Pedre B, et al. Nat Chem Biol, 2023 Apr. PMID 36732619, Free PMC Article
  2. MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT. Zhang J, et al. Redox Biol, 2022 Oct. PMID 36126419, Free PMC Article
  3. 3-Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma. Li M, et al. Liver Int, 2022 May. PMID 35243746
  4. 3-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation. Ostrakhovitch EA, et al. Exp Cell Res, 2019 Dec 15. PMID 31634482
  5. 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics. Abdollahi Govar A, et al. Br J Pharmacol, 2020 Feb. PMID 30644090, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 3-Mercaptopyruvate sulfur transferase is a protein persulfidase.
    Title: 3-Mercaptopyruvate sulfur transferase is a protein persulfidase.
  2. MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.
    Title: MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT.
  3. 3-Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma.
    Title: 3-Mercaptopyruvate sulfurtransferase represses tumour progression and predicts prognosis in hepatocellular carcinoma.
  4. 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.
    Title: 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.
  5. Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.
    Title: Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.
  6. MPST inactivation or silencing enhances the plasticity of dermal fibroblasts in a TET1 and glycolysis dependent manner and promotes adipogenic transdifferentiation.
    Title: 3-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation.
  7. 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function.
    Title: MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.
  8. In this review, we discuss the roles of non-canonical Hippo/Mst signaling pathways in lymphocyte development and functions. [review]
    Title: The non-canonical Hippo/Mst pathway in lymphocyte development and functions.
  9. distinct roles of each TUM1 isoform in the sulfur transfer processes in the cell
    Title: Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humans.
  10. The crystal structure analysis allows us to propose a detailed mechanism for MST in which an Asp-His-Ser catalytic triad is positioned to activate the nucleophilic cysteine residue and participate in general acid-base chemistry
    Title: Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC24539

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-mercaptopyruvate sulfurtransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3-mercaptopyruvate sulfurtransferase activity TAS
Traceable Author Statement
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cyanate catabolic process TAS
Traceable Author Statement
more info
  
involved_in hydrogen sulfide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance TAS
Traceable Author Statement
more info
  
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfur amino acid catabolic process TAS
Traceable Author Statement
more info
  
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-mercaptopyruvate sulfurtransferase
Names
human liver rhodanese
tRNA thiouridin modification protein 1
testicular tissue protein Li 200
NP_001013454.1
NP_001123989.1
NP_001356833.1
NP_001356834.1
NP_066949.2
XP_047297332.1
XP_047297333.1
XP_054181617.1
XP_054181618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013436.4 → NP_001013454.1  3-mercaptopyruvate sulfurtransferase isoform 2

    See identical proteins and their annotated locations for NP_001013454.1

    Status: REVIEWED

    Source sequence(s)
    Z73420
    Consensus CDS
    CCDS13939.1
    UniProtKB/Swiss-Prot
    A8MZ34, B3KP52, J3KPV7, O75750, P25325, Q6FHN9
    UniProtKB/TrEMBL
    A0A140VJX3
    Related
    ENSP00000384812.3, ENST00000401419.7
    Conserved Domains (1) summary
    PLN02723
    Location:9 → 279
    PLN02723; 3-mercaptopyruvate sulfurtransferase

  2. NM_001130517.4 → NP_001123989.1  3-mercaptopyruvate sulfurtransferase isoform 2

    See identical proteins and their annotated locations for NP_001123989.1

    Status: REVIEWED

    Source sequence(s)
    Z73420
    Consensus CDS
    CCDS13939.1
    UniProtKB/Swiss-Prot
    A8MZ34, B3KP52, J3KPV7, O75750, P25325, Q6FHN9
    UniProtKB/TrEMBL
    A0A140VJX3
    Related
    ENSP00000383950.3, ENST00000404802.7
    Conserved Domains (1) summary
    PLN02723
    Location:9 → 279
    PLN02723; 3-mercaptopyruvate sulfurtransferase

  3. NM_001369904.2 → NP_001356833.1  3-mercaptopyruvate sulfurtransferase isoform 2

    Status: REVIEWED

    Source sequence(s)
    Z73420
    Consensus CDS
    CCDS13939.1
    UniProtKB/Swiss-Prot
    A8MZ34, B3KP52, J3KPV7, O75750, P25325, Q6FHN9
    UniProtKB/TrEMBL
    A0A140VJX3
    Related
    ENSP00000342333.3, ENST00000341116.7
    Conserved Domains (1) summary
    PLN02723
    Location:9 → 279
    PLN02723; 3-mercaptopyruvate sulfurtransferase

  4. NM_001369905.2 → NP_001356834.1  3-mercaptopyruvate sulfurtransferase isoform 3

    Status: REVIEWED

    Source sequence(s)
    Z73420
    UniProtKB/TrEMBL
    B1AH49
    Conserved Domains (1) summary
    COG2897
    Location:16 → 219
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

  5. NM_021126.8 → NP_066949.2  3-mercaptopyruvate sulfurtransferase isoform 1

    See identical proteins and their annotated locations for NP_066949.2

    Status: REVIEWED

    Source sequence(s)
    BC016737, Z73420
    Consensus CDS
    CCDS46703.1
    UniProtKB/Swiss-Prot
    P25325
    Related
    ENSP00000411719.3, ENST00000429360.6
    Conserved Domains (3) summary
    PLN02723
    Location:6 → 299
    PLN02723; 3-mercaptopyruvate sulfurtransferase
    cd01448
    Location:30 → 159
    TST_Repeat_1; Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it ...
    cd01449
    Location:184 → 299
    TST_Repeat_2; Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37019742..37029815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441376.1 → XP_047297332.1  3-mercaptopyruvate sulfurtransferase isoform X1

  2. XM_047441377.1 → XP_047297333.1  3-mercaptopyruvate sulfurtransferase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    37479341..37489414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325642.1 → XP_054181617.1  3-mercaptopyruvate sulfurtransferase isoform X1

  2. XM_054325643.1 → XP_054181618.1  3-mercaptopyruvate sulfurtransferase isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013440.1: Suppressed sequence

    Description
    NM_001013440.1: This RefSeq was permanently suppressed because it was annotated to initiate translation from a downstream AUG when an upstream AUG exists, initiation from which will render this RefSeq susceptible to nonsense-mediated mRNA decay (NMD).

  2. NR_024038.1: Suppressed sequence

    Description
    NR_024038.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25325.3 GenPept UniProtKB/Swiss-Prot:P25325

Gene LinkOut

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