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MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

Gene ID: 4340, updated on 16-Apr-2024

Summary

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Official Symbol
MOGprovided by HGNC
Official Full Name
myelin oligodendrocyte glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:7197
See related
Ensembl:ENSG00000204655 MIM:159465; AllianceGenome:HGNC:7197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTN6; BTNL11; MOGIG2; NRCLP7
Summary
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 52.4) See more
Orthologs
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Genomic context

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See MOG in Genome Data Viewer
Location:
6p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29657092..29672365)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29531788..29547063)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29624869..29640142)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29589456-29590006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29590007-29590556 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29592149-29592734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29596552-29597357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29598769-29599270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29610193-29610692 Neighboring gene SUMO2 pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:29616349-29616969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29622853-29623353 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29627633-29628069 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29628451-29629365 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29629366-29630280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29630281-29631194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634045-29634654 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634655-29635264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29647510-29648030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29648031-29648552 Neighboring gene ZFP57 zinc finger protein Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29671001-29671115 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System. Eliseeva DD, et al. Biochemistry (Mosc), 2023 Apr. PMID 37080940
  2. Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica. Ambika S, et al. Indian J Ophthalmol, 2022 Jan. PMID 34937238, Free PMC Article
  3. Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases. Schanda K, et al. Neurol Neuroimmunol Neuroinflamm, 2021 Jul. PMID 34131067, Free PMC Article
  4. Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination. Jayananth P, et al. J Biomol Struct Dyn, 2022 Sep. PMID 33663341
  5. An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder. Zai G, et al. Psychiatry Res Neuroimaging, 2021 Jan 30. PMID 33302097, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder.
    Title: Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder.
  2. Barriers to access and unmet needs to neuromyelitis optica spectrum disorders care in an Argentinean cohort.
    Title: Barriers to access and unmet needs to neuromyelitis optica spectrum disorders care in an Argentinean cohort.
  3. MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.
    Title: MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.
  4. White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder.
    Title: White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder.
  5. Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.
    Title: Myelin Oligodendrocyte Glycoprotein as an Autoantigen in Inflammatory Demyelinating Diseases of the Central Nervous System.
  6. Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination.
    Title: Imperative role of glycosylation in human MOG-HLA interaction: molecular insights of MOG-Ab associated demyelination.
  7. Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases.
    Title: Differential Binding of Autoantibodies to MOG Isoforms in Inflammatory Demyelinating Diseases.
  8. Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.
    Title: Comparative study of AQP4 antibody-related diseases and MOG antibody-related diseases among the population in Hunan, China.
  9. Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica.
    Title: Clinical profile, imaging features and short term visual outcomes of Indian optic neuritis patients with and without seromarkers for myelin oligodendrocyte glycoprotein and neuromyelitis optica.
  10. Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica.
    Title: Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica.
Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Narcolepsy 7
MedGen: C3280266 OMIM: 614250 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
myelin-oligodendrocyte glycoprotein
Names
MOG AluA
MOG AluB
MOG Ig-AluB
MOG alpha-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031873.1 RefSeqGene

    Range
    5112..20385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008228.3 → NP_001008229.1  myelin-oligodendrocyte glycoprotein isoform alpha3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha3) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha3) is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, U18843, U64564
    Consensus CDS
    CCDS34369.1
    UniProtKB/TrEMBL
    A0A0G2JHA9
    Related
    ENSP00000379932.3, ENST00000396704.7
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  2. NM_001008229.3 → NP_001008230.1  myelin-oligodendrocyte glycoprotein isoform beta2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta2) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta2), that is missing an internal segment, compared to isoform beta1.
    Source sequence(s)
    AL119259, AY566853, DA139582, DA140757, U64564
    Consensus CDS
    CCDS34368.1
    UniProtKB/TrEMBL
    A0A0G2JI49
    Related
    ENSP00000366088.4, ENST00000376891.8
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  3. NM_001170418.2 → NP_001163889.1  myelin-oligodendrocyte glycoprotein isoform alpha6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha6) has a distinct C-terminus and is shorter than isoform beta1.
    Source sequence(s)
    AL119259, AY566847, DA139582, DA140757, U64564
    Consensus CDS
    CCDS54977.1
    UniProtKB/TrEMBL
    E9PG44
    Related
    ENSP00000420350.1, ENST00000490427.5

  4. NM_001363610.2 → NP_001350539.1  myelin-oligodendrocyte glycoprotein isoform 10 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) represents the longest transcript and encodes the longest isoform (10).
    Source sequence(s)
    AL645936, BC035938
    Consensus CDS
    CCDS87379.1
    UniProtKB/TrEMBL
    A0A0G2JHM8
    Related
    ENSP00000366091.4, ENST00000376894.8
    Conserved Domains (1) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

  5. NM_002433.5 → NP_002424.3  myelin-oligodendrocyte glycoprotein isoform beta1 precursor

    See identical proteins and their annotated locations for NP_002424.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta1) encodes the beta1 isoform, also known as isoform 1.
    Source sequence(s)
    AL119259, AY566852, DA139582, DA140757, U64564
    Consensus CDS
    CCDS4667.1
    UniProtKB/TrEMBL
    Q5SSB8
    Related
    ENSP00000366095.3, ENST00000376898.7
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  6. NM_206809.4 → NP_996532.2  myelin-oligodendrocyte glycoprotein isoform alpha1 precursor

    See identical proteins and their annotated locations for NP_996532.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha1) contains an additional segment in the coding region compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to variant beta1. The resulting isoform (alpha1), also known as isoform 2, contains a shorter and distinct C-terminus compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, U64564, X74511
    Consensus CDS
    CCDS34370.1
    UniProtKB/Swiss-Prot
    A6NDR4, A6NNJ9, A8MY31, B0UZR9, E9PGF0, F8W9D5, O00713, O00714, O00715, Q13054, Q13055, Q14855, Q16653, Q29ZN8, Q56UY0, Q5JNX7, Q5JNY1, Q5JNY2, Q5JNY4, Q5SSB5, Q5SSB6, Q5STL9, Q5STM0, Q5STM1, Q5STM2, Q5STM5, Q5SUK5, Q5SUK7, Q5SUK8, Q5SUK9, Q5SUL0, Q5SUL1, Q8IYG5, Q92891, Q92892, Q92893, Q92894, Q92895, Q93053, Q96KU9, Q96KV0, Q96KV1, Q99605
    UniProtKB/TrEMBL
    Q5SSB8
    Related
    ENSP00000366115.3, ENST00000376917.8
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  7. NM_206810.4 → NP_996533.2  myelin-oligodendrocyte glycoprotein isoform beta5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta5) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta5), also known as isoform 3, that is missing an internal segment, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, U18803, U64564
    Consensus CDS
    CCDS34367.1
    UniProtKB/TrEMBL
    A0A0G2JIU9
    Related
    ENSP00000379929.2, ENST00000396701.6
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  8. NM_206811.4 → NP_996534.2  myelin-oligodendrocyte glycoprotein isoform beta3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta3) has multiple differences in the coding region, compared to variant beta1. The resulting isoform (beta3), also known as isoform 4, is shorter, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, U18840, U64564
    Consensus CDS
    CCDS34366.1
    UniProtKB/TrEMBL
    A0A0G2JKI0
    Related
    ENSP00000417405.1, ENST00000494692.5
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  9. NM_206812.4 → NP_996535.2  myelin-oligodendrocyte glycoprotein isoform alpha2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha2) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha2), also known as isoform 5, is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, U18799, U64564
    Consensus CDS
    CCDS47394.1
    UniProtKB/TrEMBL
    A0A0G2JI49
    Related
    ENSP00000410866.2, ENST00000431798.6
    Conserved Domains (2) summary
    cd05713
    Location:46 → 144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40 → 144
    IG_like; Immunoglobulin like

  10. NM_206814.6 → NP_996537.3  myelin-oligodendrocyte glycoprotein isoform alpha5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha5) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha5) has a distinct C-terminus and is shorter than isoform beta1.
    Source sequence(s)
    AK308949, AL119259, DA139582, DA140757, U64564
    Consensus CDS
    CCDS47395.2
    UniProtKB/TrEMBL
    A0A0G2JHB7
    Related
    ENSP00000366085.2, ENST00000376888.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    29657092..29672365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    922801..938073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1143564..1158838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    922637..937911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    922209..937479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    922473..937739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    922592..937866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    966127..981397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    29531788..29547063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206813.4: Suppressed sequence

    Description
    NM_206813.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16653.2 GenPept UniProtKB/Swiss-Prot:Q16653

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