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MCM7 minichromosome maintenance complex component 7 [ Homo sapiens (human) ]

Gene ID: 4176, updated on 7-Apr-2024

Summary

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Official Symbol
MCM7provided by HGNC
Official Full Name
minichromosome maintenance complex component 7provided by HGNC
Primary source
HGNC:HGNC:6950
See related
Ensembl:ENSG00000166508 MIM:600592; AllianceGenome:HGNC:6950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues See more
Orthologs
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Genomic context

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See MCM7 in Genome Data Viewer
Location:
7q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100092728..100101397, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101332574..101341242, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99690351..99699020, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene Sharpr-MPRA regulatory region 7718 Neighboring gene zinc finger protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26334 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99679591-99680572 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99684712-99685405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18414 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:99686990-99688189 Neighboring gene Sharpr-MPRA regulatory region 1952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99693124-99693624 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18415 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99698720-99699272 Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99704970-99705470 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99708249-99708476 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99723160-99723829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18417 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene metallo-beta-lactamase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway. Su D. Immunopharmacol Immunotoxicol, 2022 Feb. PMID 34821526
  2. Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability. Ravindran E, et al. J Med Genet, 2022 May. PMID 34059554, Free PMC Article
  3. MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas. Hallén T, et al. Eur J Endocrinol, 2021 Apr. PMID 33524001
  4. MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway. Yang Y, et al. J Cell Biochem, 2020 Feb. PMID 31535400
  5. High minichromosome maintenance protein 7 proliferation indices: a powerful predictor of progression in pancreatic neuroendocrine neoplasms without distant metastasis at the time of surgery. Ban X, et al. Hum Pathol, 2019 Mar. PMID 30447299

See all (367) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells.
    Title: Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells.
  2. Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability.
    Title: Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability.
  3. MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.
    Title: MCM7 affects the cisplatin resistance of liver cancer cells and the development of liver cancer by regulating the PI3K/Akt signaling pathway.
  4. MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
    Title: MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.
  5. miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway.
    Title: miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway.
  6. MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer.
    Title: MCM2-7 complex is a novel druggable target for neuroendocrine prostate cancer.
  7. The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
    Title: The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.
  8. MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway.
    Title: MCM7 silencing promotes cutaneous melanoma cell autophagy and apoptosis by inactivating the AKT1/mTOR signaling pathway.
  9. MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.
    Title: MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas.
  10. In this study, we demonstrated for the first time that MCM2 among MCM2-7 except for MCM5 is specifically degraded, and that MCM2 and MCM7 are localized in the cytoplasm in senescent cells. To examine the relationship between the cytoplasmic localization of MCM proteins and cell cycle phase, the distribution of DNA content of cells showing cytoplasmic localization of MCM2 and MCM7 was examined.
    Title: Changes in MCM2-7 proteins at senescence.
Submit: New GeneRIF Correction See all GeneRIFs (86)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 7 (MCM7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify minichromosome maintenance complex component 7 isoform 1 (MCM7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of minichromosome maintenance complex component 7 (MCM7) in the nucleoli of Jurkat T-cells PubMed
tat Interaction of HIV-1 Tat with MCM7 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA binding TAS
Traceable Author Statement
more info
 PubMed 
contributes_to DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated DNA replication initiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of CMG complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MCM complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of MCM complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of chromatin TAS
Traceable Author Statement
more info
 PubMed 
located_in chromosome, telomeric region HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA replication licensing factor MCM7
Names
CDC47 homolog
homolog of S. cerevisiae Cdc47
minichromosome maintenance deficient 7
protein phosphatase 1, regulatory subunit 104
NP_001265524.1
NP_005907.3
NP_877577.1
XP_005250405.1
XP_054214227.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278595.2 → NP_001265524.1  DNA replication licensing factor MCM7 isoform 2

    See identical proteins and their annotated locations for NP_001265524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional internal segment, which results in translation initiation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC073842
    Consensus CDS
    CCDS5684.1
    UniProtKB/TrEMBL
    B3KUD7
    Related
    ENST00000489841.6
    Conserved Domains (2) summary
    smart00350
    Location:1 → 465
    MCM; minichromosome maintenance proteins
    cl21455
    Location:200 → 339
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_005916.5 → NP_005907.3  DNA replication licensing factor MCM7 isoform 1

    See identical proteins and their annotated locations for NP_005907.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC073842
    Consensus CDS
    CCDS5683.1
    UniProtKB/Swiss-Prot
    A4D2A1, A4D2A2, E9PGN9, P33993, Q15076, Q96D34, Q96GL1
    UniProtKB/TrEMBL
    A0A0S2Z4A5, B2RBA6
    Related
    ENSP00000307288.5, ENST00000303887.10
    Conserved Domains (2) summary
    smart00350
    Location:145 → 641
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:10 → 93
    MCM_N; MCM N-terminal domain

  3. NM_182776.3 → NP_877577.1  DNA replication licensing factor MCM7 isoform 2

    See identical proteins and their annotated locations for NP_877577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end, contains an additional internal segment, and initiates translation from an in-frame downstream AUG compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK055379, AK226175
    Consensus CDS
    CCDS5684.1
    UniProtKB/TrEMBL
    B3KUD7
    Related
    ENST00000485286.6
    Conserved Domains (2) summary
    smart00350
    Location:1 → 465
    MCM; minichromosome maintenance proteins
    cl21455
    Location:200 → 339
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100092728..100101397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250348.4 → XP_005250405.1  DNA replication licensing factor MCM7 isoform X1

    UniProtKB/TrEMBL
    B3KUD7, C9J8M6
    Related
    ENSP00000411295.2, ENST00000425308.6
    Conserved Domains (3) summary
    smart00350
    Location:38 → 534
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:11 → 58
    MCM_N; MCM N-terminal domain
    cl21455
    Location:269 → 408
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101332574..101341242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358252.1 → XP_054214227.1  DNA replication licensing factor MCM7 isoform X1

    UniProtKB/TrEMBL
    C9J8M6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33993.4 GenPept UniProtKB/Swiss-Prot:P33993

Gene LinkOut

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