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MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 4145, updated on 11-Apr-2024

Summary

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Official Symbol
MATKprovided by HGNC
Official Full Name
megakaryocyte-associated tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:6906
See related
Ensembl:ENSG00000007264 MIM:600038; AllianceGenome:HGNC:6906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
Summary
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 4.5), bone marrow (RPKM 3.5) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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See MATK in Genome Data Viewer
Location:
19p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (3777973..3801799, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (3757233..3781064, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3777971..3801797, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3770519-3771018 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene retina and anterior neural fold homeobox 2 Neighboring gene MPRA-validated peak3254 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3784812-3785807 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3787338-3787536 Neighboring gene MPRA-validated peak3255 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3809153-3809388 Neighboring gene zinc finger RNA binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 15218 Neighboring gene MPRA-validated peak3257 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3831251-3831840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3843229-3843728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3849523-3850024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3871123-3871622 Neighboring gene ferritin light chain pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. Belot MP, et al. J Cell Biochem, 2007 Dec 1. PMID 17492661
  2. Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus. Nakayama Y, et al. Exp Cell Res, 2006 Jul 15. PMID 16707123
  3. Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner. Zagozdzon R, et al. Cell Signal, 2006 Jun. PMID 16168623
  4. Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase. Nakayama Y, et al. Exp Cell Res, 2005 Apr 1. PMID 15748901
  5. Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors. Kim SO, et al. Cancer, 2004 Sep 1. PMID 15329911

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1.
    Title: IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells.
  2. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma.
    Title: Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma.
  3. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells.
    Title: Decreased CHK protein levels are associated with Src activation in colon cancer cells.
  4. Progesterone increases MATK in mast cells and reducs cell proliferation.
    Title: Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.
  5. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms
    Title: Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells.
  6. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase
    Title: Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.
  7. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation.
    Title: Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus.
  8. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation.
    Title: Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.
  9. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines
    Title: Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
  10. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells.
    Title: Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1708, MGC2101, DKFZp434N1212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
megakaryocyte-associated tyrosine-protein kinase
Names
CSK homologous kinase
Csk-homologous kinase
Csk-type protein tyrosine kinase
HYL tyrosine kinase
hematopoietic consensus tyrosine-lacking kinase
hydroxyaryl-protein kinase
leukocyte carboxyl-terminal src kinase related
protein kinase HYL
tyrosine kinase MATK
tyrosine-protein kinase CTK
tyrosylprotein kinase
NP_002369.2
NP_647611.1
NP_647612.1
XP_011526320.1
XP_047294798.1
XP_047294799.1
XP_054177010.1
XP_054177011.1
XP_054177012.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002378.4 → NP_002369.2  megakaryocyte-associated tyrosine-protein kinase isoform b

    See identical proteins and their annotated locations for NP_002369.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate region at the 5' end of the coding region and lacks two exons in the coding region, as compared to variant 1. The encoded isoform b has a slightly longer and unique N-terminus compared to isoform a.
    Source sequence(s)
    AK055395, BC000114, DA592994
    Consensus CDS
    CCDS12113.1
    UniProtKB/TrEMBL
    B2RDR6, K7EQY5
    Related
    ENSP00000378485.1, ENST00000395045.6
    Conserved Domains (4) summary
    cd09937
    Location:119 → 216
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:51 → 109
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    smart00221
    Location:236 → 479
    STYKc; Protein kinase; unclassified specificity
    cd05083
    Location:229 → 482
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

  2. NM_139354.3 → NP_647611.1  megakaryocyte-associated tyrosine-protein kinase isoform c

    See identical proteins and their annotated locations for NP_647611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, and utilizes a downstream in-frame start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL137754, BG396388, BQ109562, X77278
    Consensus CDS
    CCDS42468.1
    UniProtKB/TrEMBL
    Q16176
    Related
    ENSP00000378481.1, ENST00000395040.6
    Conserved Domains (3) summary
    cd09937
    Location:77 → 174
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:9 → 67
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    cd05083
    Location:187 → 440
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

  3. NM_139355.3 → NP_647612.1  megakaryocyte-associated tyrosine-protein kinase isoform a

    See identical proteins and their annotated locations for NP_647612.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform a.
    Source sequence(s)
    BC000114, BG396388, BM925586
    Consensus CDS
    CCDS12114.1
    UniProtKB/Swiss-Prot
    B3KNZ9, P42679, Q9NST8
    UniProtKB/TrEMBL
    B2RDR6, F1T0G6, K7EQY5
    Related
    ENSP00000308734.5, ENST00000310132.11
    Conserved Domains (3) summary
    cd09937
    Location:118 → 215
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:50 → 108
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    cd05083
    Location:228 → 481
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    3777973..3801799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438843.1 → XP_047294799.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

  2. XM_047438842.1 → XP_047294798.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

  3. XM_011528018.2 → XP_011526320.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011526320.1

    UniProtKB/Swiss-Prot
    B3KNZ9, P42679, Q9NST8
    UniProtKB/TrEMBL
    B2RDR6, F1T0G6, K7EQY5
    Conserved Domains (3) summary
    cd09937
    Location:118 → 215
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11811
    Location:50 → 108
    SH3_CHK; Src Homology 3 domain of CSK homologous kinase
    cd05083
    Location:228 → 481
    PTKc_Chk; Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    3757233..3781064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321037.1 → XP_054177012.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

  2. XM_054321036.1 → XP_054177011.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

  3. XM_054321035.1 → XP_054177010.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B3KNZ9, P42679, Q9NST8
    UniProtKB/TrEMBL
    F1T0G6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42679.1 GenPept UniProtKB/Swiss-Prot:P42679

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