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MAS1 MAS1 proto-oncogene, G protein-coupled receptor [ Homo sapiens (human) ]

Gene ID: 4142, updated on 5-Mar-2024

Summary

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Official Symbol
MAS1provided by HGNC
Official Full Name
MAS1 proto-oncogene, G protein-coupled receptorprovided by HGNC
Primary source
HGNC:HGNC:6899
See related
Ensembl:ENSG00000130368 MIM:165180; AllianceGenome:HGNC:6899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAS; MGRA
Summary
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Orthologs
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Genomic context

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See MAS1 in Genome Data Viewer
Location:
6q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (159888787..159917447)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (161134461..161165992)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160312020..160338479)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:160210497-160211160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25393 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160215999-160216870 Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:160240240-160240966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160242614-160243420 Neighboring gene PARN like ribonuclease domain containing exonuclease 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160251537-160252270 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:160296296-160296948 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:160339473-160340672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160399030-160400020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:160401011-160402001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25399 Neighboring gene Sharpr-MPRA regulatory region 15614 Neighboring gene Sharpr-MPRA regulatory region 12427 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:160408528-160409102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160417106-160417992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160417993-160418878 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:160419578-160420777 Neighboring gene insulin like growth factor 2 receptor Neighboring gene antisense of IGF2R non-protein coding RNA Neighboring gene uncharacterized LOC124901451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25401

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mas receptor endocytosis and signaling in health and disease. Rukavina Mikusic NL, et al. Prog Mol Biol Transl Sci, 2023. PMID 36631200
  2. Sex Difference in MasR Expression and Functions in the Renal System. Choopani S, et al. J Renin Angiotensin Aldosterone Syst, 2022. PMID 36148474, Free PMC Article
  3. Angiotensin 1-7 formation in breast tissue is attenuated in breast cancer - a study on the metabolism of angiotensinogen in breast cancer cell lines. Bujak-Gizycka B, et al. J Physiol Pharmacol, 2019 Aug. PMID 31642813
  4. The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients. Nakajima T, et al. Gynecol Obstet Invest, 2018. PMID 29982252
  5. Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma. Su YY, et al. J Renin Angiotensin Aldosterone Syst, 2017 Jul-Sep. PMID 28747140, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
    Title: Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.
  2. Mas receptor endocytosis and signaling in health and disease.
    Title: Mas receptor endocytosis and signaling in health and disease.
  3. Sex Difference in MasR Expression and Functions in the Renal System.
    Title: Sex Difference in MasR Expression and Functions in the Renal System.
  4. The function of the ACE2/Ang(1-7)/Mas receptor axis of the renin-angiotensin system in myocardial ischemia reperfusion injury.
    Title: The function of the ACE2/Ang(1-7)/Mas receptor axis of the renin-angiotensin system in myocardial ischemia reperfusion injury.
  5. Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent.
    Title: Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent.
  6. Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome.
    Title: Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome.
  7. Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis.
    Title: Impact of angiotensin II type 1 and G-protein-coupled Mas receptor expression on the pulmonary performance of patients with idiopathic pulmonary fibrosis.
  8. Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle.
    Title: Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle.
  9. Angiotensin- and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease.
    Title: Angiotensin-Ⅱ and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease.
  10. ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease.
    Title: ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables angiotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables angiotensin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables angiotensin type II receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
  
involved_in response to gonadotropin IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene Mas
Names
MAS1 oncogene
Mas-related G protein-coupled receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366704.2 → NP_001353633.1  proto-oncogene Mas

    Status: REVIEWED

    Source sequence(s)
    AL035691
    Consensus CDS
    CCDS5272.1
    UniProtKB/Swiss-Prot
    E1P5B3, P04201, Q2TBC9, Q6FG47
    UniProtKB/TrEMBL
    W8W3P4
    Related
    ENSP00000252660.4, ENST00000252660.5
    Conserved Domains (1) summary
    cd15110
    Location:33 → 307
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_002377.4 → NP_002368.1  proto-oncogene Mas

    See identical proteins and their annotated locations for NP_002368.1

    Status: REVIEWED

    Source sequence(s)
    AL035691, DB475311
    Consensus CDS
    CCDS5272.1
    UniProtKB/Swiss-Prot
    E1P5B3, P04201, Q2TBC9, Q6FG47
    UniProtKB/TrEMBL
    W8W3P4
    Related
    ENSP00000501180.2, ENST00000674077.2
    Conserved Domains (1) summary
    cd15110
    Location:33 → 307
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    159888787..159917447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418776.1 → XP_047274732.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    E1P5B3, P04201, Q2TBC9, Q6FG47
    UniProtKB/TrEMBL
    W8W3P4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    161134461..161165992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355443.1 → XP_054211418.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    E1P5B3, P04201, Q2TBC9, Q6FG47
    UniProtKB/TrEMBL
    W8W3P4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04201.1 GenPept UniProtKB/Swiss-Prot:P04201

Gene LinkOut

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