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MARK3 microtubule affinity regulating kinase 3 [ Homo sapiens (human) ]

Gene ID: 4140, updated on 7-Apr-2024

Summary

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Official Symbol
MARK3provided by HGNC
Official Full Name
microtubule affinity regulating kinase 3provided by HGNC
Primary source
HGNC:HGNC:6897
See related
Ensembl:ENSG00000075413 MIM:602678; AllianceGenome:HGNC:6897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KP78; VIPB; CTAK1; PAR1A; Par-1a
Summary
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 22.5), testis (RPKM 17.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q32.32-q32.33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103385415..103503831)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97621350..97739863)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103851752..103970168)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103838386-103839043 Neighboring gene high mobility group box 3 pseudogene 26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103850577-103851568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103851569-103852558 Neighboring gene ribosomal protein SA pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103866087-103866886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9104 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103921390-103921890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103921891-103922391 Neighboring gene uncharacterized LOC112268130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103984081-103984968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103986745-103987632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6156 Neighboring gene creatine kinase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese. Xiao SM, et al. J Clin Endocrinol Metab, 2013 Nov. PMID 23894155
  2. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Murphy JM, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17726107, Free PMC Article
  3. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. Ono T, et al. Cytogenet Cell Genet, 1997. PMID 9533022
  4. The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Machino H, et al. Commun Biol, 2022 Jan 11. PMID 35017636, Free PMC Article
  5. Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Ansar M, et al. Hum Mol Genet, 2018 Aug 1. PMID 29771303, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
    Title: The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
  2. A non-synonymous homozygous variant (NM_001128918.2: c.1708C > G: p.Arg570Gly) in the MARK3 leads to visual impairment and progressive phthisis bulbi.
    Title: Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.
  3. Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2.
    Title: MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
  4. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1
    Title: Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.
  5. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients.
    Title: Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.
  7. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
  8. interaction between Mitf and C-TAK1 was demonstrated.
    Title: C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.
  9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: New sequence variants associated with bone mineral density.
  10. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain
    Title: Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Visual impairment and progressive phthisis bulbi
MedGen: C4748978 OMIM: 618283 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP/microtubule affinity-regulating kinase 3
Names
C-TAK1
ELKL motif kinase 2
EMK-2
cdc25C-associated protein kinase 1
protein kinase STK10
ser/Thr protein kinase PAR-1
serine/threonine-protein kinase p78
NP_001122390.2
NP_001122391.2
NP_001122392.2
NP_001122393.2
NP_001397984.1
NP_001397985.1
NP_002367.5
XP_005267698.2
XP_005267699.2
XP_005267700.2
XP_011535071.1
XP_016876780.1
XP_016876781.1
XP_016876783.1
XP_016876784.1
XP_016876786.1
XP_016876787.1
XP_016876788.1
XP_016876790.1
XP_047287333.1
XP_047287334.1
XP_047287335.1
XP_047287337.1
XP_047287338.1
XP_047287339.1
XP_047287340.1
XP_047287341.1
XP_047287342.1
XP_047287343.1
XP_047287344.1
XP_047287345.1
XP_047287346.1
XP_047287347.1
XP_047287348.1
XP_047287349.1
XP_047287350.1
XP_047287351.1
XP_047287352.1
XP_054232027.1
XP_054232028.1
XP_054232029.1
XP_054232030.1
XP_054232031.1
XP_054232032.1
XP_054232033.1
XP_054232034.1
XP_054232035.1
XP_054232036.1
XP_054232037.1
XP_054232038.1
XP_054232039.1
XP_054232040.1
XP_054232041.1
XP_054232042.1
XP_054232043.1
XP_054232044.1
XP_054232045.1
XP_054232046.1
XP_054232047.1
XP_054232048.1
XP_054232049.1
XP_054232050.1
XP_054232051.1
XP_054232052.1
XP_054232053.1
XP_054232054.1
XP_054232055.1
XP_054232056.1
XP_054232057.1
XP_054232058.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030339.2 RefSeqGene

    Range
    5052..123468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128918.3 → NP_001122390.2  MAP/microtubule affinity-regulating kinase 3 isoform a

    See identical proteins and their annotated locations for NP_001122390.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF465413, AL133367, BC024773, BX248250, DA707357
    Consensus CDS
    CCDS45165.1
    UniProtKB/Swiss-Prot
    A0A0A0MQR8, A0A0A0MST9, A0A0A0MT23, O60219, P27448, Q86TT8, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34
    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000411397.2, ENST00000429436.7
    Conserved Domains (3) summary
    cd12196
    Location:654 → 751
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  2. NM_001128919.3 → NP_001122391.2  MAP/microtubule affinity-regulating kinase 3 isoform b

    See identical proteins and their annotated locations for NP_001122391.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF387637, AF465413, AL133367, BC024773, BX248250, DA707357
    Consensus CDS
    CCDS45166.1
    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000450772.1, ENST00000553942.5
    Conserved Domains (3) summary
    cd12196
    Location:645 → 742
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  3. NM_001128920.3 → NP_001122392.2  MAP/microtubule affinity-regulating kinase 3 isoform d

    See identical proteins and their annotated locations for NP_001122392.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL133367, BC024773, DA707357, M80359
    Consensus CDS
    CCDS55947.1
    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000216288.7, ENST00000216288.11
    Conserved Domains (3) summary
    cd12196
    Location:614 → 711
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  4. NM_001128921.3 → NP_001122393.2  MAP/microtubule affinity-regulating kinase 3 isoform e

    See identical proteins and their annotated locations for NP_001122393.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL133367, BC024773, BX161395, DA707357, KF456011
    Consensus CDS
    CCDS45167.1
    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000402104.3, ENST00000440884.7
    Conserved Domains (4) summary
    cd12196
    Location:560 → 657
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:56 → 228
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:246 → 288
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:55 → 228
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001411055.1 → NP_001397984.1  MAP/microtubule affinity-regulating kinase 3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL133367, KF456011
    Consensus CDS
    CCDS91938.1
    UniProtKB/TrEMBL
    A0A7I2V2N8
    Related
    ENSP00000502999.1, ENST00000677432.1

  6. NM_001411056.1 → NP_001397985.1  MAP/microtubule affinity-regulating kinase 3 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL133367, KF456011
    Consensus CDS
    CCDS91940.1
    UniProtKB/TrEMBL
    A0A7I2V5G3
    Related
    ENSP00000504493.1, ENST00000678619.1

  7. NM_002376.7 → NP_002367.5  MAP/microtubule affinity-regulating kinase 3 isoform c

    See identical proteins and their annotated locations for NP_002367.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL133367, BC024773, DA707357
    Consensus CDS
    CCDS41993.1
    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000303698.9, ENST00000303622.13
    Conserved Domains (3) summary
    cd12196
    Location:630 → 727
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103385415..103503831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267641.6 → XP_005267698.2  MAP/microtubule affinity-regulating kinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A7I2YQF7, J3KNR0
    Related
    ENSP00000503568.1, ENST00000676938.1
    Conserved Domains (3) summary
    cd12196
    Location:639 → 736
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  2. XM_005267643.6 → XP_005267700.2  MAP/microtubule affinity-regulating kinase 3 isoform X24

    UniProtKB/TrEMBL
    H0YNV4, J3KNR0
    Related
    ENSP00000454169.2, ENST00000560417.6
    Conserved Domains (3) summary
    cd12196
    Location:544 → 641
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  3. XM_005267642.6 → XP_005267699.2  MAP/microtubule affinity-regulating kinase 3 isoform X3

    See identical proteins and their annotated locations for XP_005267699.2

    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000451623.2, ENST00000556744.2
    Conserved Domains (3) summary
    cd12196
    Location:638 → 735
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:325 → 367
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:55 → 307
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  4. XM_017021292.3 → XP_016876781.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

    UniProtKB/TrEMBL
    J3KNR0

  5. XM_017021291.3 → XP_016876780.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

    UniProtKB/TrEMBL
    J3KNR0
    Related
    ENSP00000504859.1, ENST00000678175.1

  6. XM_047431391.1 → XP_047287347.1  MAP/microtubule affinity-regulating kinase 3 isoform X25

  7. XM_047431378.1 → XP_047287334.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

  8. XM_047431382.1 → XP_047287338.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

  9. XM_047431384.1 → XP_047287340.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

  10. XM_047431392.1 → XP_047287348.1  MAP/microtubule affinity-regulating kinase 3 isoform X26

  11. XM_047431388.1 → XP_047287344.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

  12. XM_017021294.3 → XP_016876783.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

    UniProtKB/TrEMBL
    A0A7I2V4G7, A0A7I2V639
    Related
    ENSP00000504622.1, ENST00000677360.1

  13. XM_017021295.3 → XP_016876784.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

    UniProtKB/TrEMBL
    A0A7I2V4G7

  14. XM_017021298.3 → XP_016876787.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

    UniProtKB/TrEMBL
    A0A7I2V3B9, H0YKP9
    Related
    ENSP00000503216.1, ENST00000677829.1

  15. XM_017021297.3 → XP_016876786.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

    UniProtKB/TrEMBL
    A0A7I2V4G7

  16. XM_017021299.3 → XP_016876788.1  MAP/microtubule affinity-regulating kinase 3 isoform X21

    UniProtKB/TrEMBL
    A0A7I2V4G7

  17. XM_047431390.1 → XP_047287346.1  MAP/microtubule affinity-regulating kinase 3 isoform X23

  18. XM_017021301.3 → XP_016876790.1  MAP/microtubule affinity-regulating kinase 3 isoform X27

    UniProtKB/TrEMBL
    A0A7I2V2E3, A0A7I2V4G7
    Related
    ENSP00000502861.1, ENST00000678237.1
    Conserved Domains (3) summary
    cd12196
    Location:523 → 620
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14407
    Location:194 → 236
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:1 → 176
    PKc_like; Protein Kinases, catalytic domain

  19. XM_047431386.1 → XP_047287342.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

  20. XM_047431381.1 → XP_047287337.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

  21. XM_047431385.1 → XP_047287341.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

  22. XM_047431377.1 → XP_047287333.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

  23. XM_047431379.1 → XP_047287335.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

  24. XM_047431387.1 → XP_047287343.1  MAP/microtubule affinity-regulating kinase 3 isoform X14

  25. XM_047431383.1 → XP_047287339.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

  26. XM_047431389.1 → XP_047287345.1  MAP/microtubule affinity-regulating kinase 3 isoform X22

  27. XM_011536769.4 → XP_011535071.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

    UniProtKB/TrEMBL
    A0A7I2V4G7
    Related
    ENST00000676745.1
    Conserved Domains (4) summary
    cd12196
    Location:574 → 671
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    COG0515
    Location:2 → 328
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14407
    Location:245 → 287
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:2 → 227
    PKc_like; Protein Kinases, catalytic domain

  28. XM_047431394.1 → XP_047287350.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

  29. XM_047431393.1 → XP_047287349.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

  30. XM_047431396.1 → XP_047287352.1  MAP/microtubule affinity-regulating kinase 3 isoform X30

  31. XM_047431395.1 → XP_047287351.1  MAP/microtubule affinity-regulating kinase 3 isoform X29

    Related
    ENSP00000450460.1, ENST00000554627.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97621350..97739863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376053.1 → XP_054232028.1  MAP/microtubule affinity-regulating kinase 3 isoform X2

    UniProtKB/TrEMBL
    A0A7I2YQF7

  2. XM_054376075.1 → XP_054232050.1  MAP/microtubule affinity-regulating kinase 3 isoform X24

    UniProtKB/TrEMBL
    H0YNV4

  3. XM_054376054.1 → XP_054232029.1  MAP/microtubule affinity-regulating kinase 3 isoform X3

  4. XM_054376059.1 → XP_054232034.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

  5. XM_054376057.1 → XP_054232032.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

  6. XM_054376076.1 → XP_054232051.1  MAP/microtubule affinity-regulating kinase 3 isoform X25

  7. XM_054376055.1 → XP_054232030.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

  8. XM_054376060.1 → XP_054232035.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

  9. XM_054376062.1 → XP_054232037.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

  10. XM_054376077.1 → XP_054232052.1  MAP/microtubule affinity-regulating kinase 3 isoform X26

  11. XM_054376066.1 → XP_054232041.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

  12. XM_054376067.1 → XP_054232042.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

    UniProtKB/TrEMBL
    A0A7I2V639

  13. XM_054376068.1 → XP_054232043.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

  14. XM_054376071.1 → XP_054232046.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

    UniProtKB/TrEMBL
    A0A7I2V3B9

  15. XM_054376069.1 → XP_054232044.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

  16. XM_054376072.1 → XP_054232047.1  MAP/microtubule affinity-regulating kinase 3 isoform X21

  17. XM_054376074.1 → XP_054232049.1  MAP/microtubule affinity-regulating kinase 3 isoform X23

  18. XM_054376078.1 → XP_054232053.1  MAP/microtubule affinity-regulating kinase 3 isoform X27

    UniProtKB/TrEMBL
    A0A7I2V2E3

  19. XM_054376064.1 → XP_054232039.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

  20. XM_054376058.1 → XP_054232033.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

  21. XM_054376063.1 → XP_054232038.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

  22. XM_054376052.1 → XP_054232027.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

  23. XM_054376056.1 → XP_054232031.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

  24. XM_054376065.1 → XP_054232040.1  MAP/microtubule affinity-regulating kinase 3 isoform X14

  25. XM_054376061.1 → XP_054232036.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

  26. XM_054376073.1 → XP_054232048.1  MAP/microtubule affinity-regulating kinase 3 isoform X22

  27. XM_054376070.1 → XP_054232045.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

  28. XM_054376081.1 → XP_054232056.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

  29. XM_054376080.1 → XP_054232055.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

  30. XM_054376079.1 → XP_054232054.1  MAP/microtubule affinity-regulating kinase 3 isoform X31

  31. XM_054376083.1 → XP_054232058.1  MAP/microtubule affinity-regulating kinase 3 isoform X30

  32. XM_054376082.1 → XP_054232057.1  MAP/microtubule affinity-regulating kinase 3 isoform X29

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27448.5 GenPept UniProtKB/Swiss-Prot:P27448

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