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LASP1 LIM and SH3 protein 1 [ Homo sapiens (human) ]

Gene ID: 3927, updated on 7-Apr-2024

Summary

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Official Symbol
LASP1provided by HGNC
Official Full Name
LIM and SH3 protein 1provided by HGNC
Primary source
HGNC:HGNC:6513
See related
Ensembl:ENSG00000002834 MIM:602920; AllianceGenome:HGNC:6513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLN50; Lasp-1
Summary
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in small intestine (RPKM 79.0), duodenum (RPKM 59.7) and 25 other tissues See more
Orthologs
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Genomic context

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See LASP1 in Genome Data Viewer
Location:
17q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38870058..38921770)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39733108..39784846)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37026311..37078023)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.2188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37024565-37025165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12083 Neighboring gene tRNA-Cys (anticodon GCA) 2-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8444 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:37027573-37028174 Neighboring gene tRNA-Cys (anticodon GCA) 4-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37036179-37036761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37037929-37038511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37049153-37049726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37051813-37052334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37052335-37052856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37052857-37053378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37054945-37055466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37055467-37055986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37057617-37058242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37068165-37069124 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37072928-37073106 Neighboring gene microRNA 6779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37078252-37078862 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:37085946-37086491 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:37086492-37087038 Neighboring gene LASP1 neighbor Neighboring gene F-box protein 47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas. Vanderheijden C, et al. J Neurooncol, 2022 May. PMID 35507100, Free PMC Article
  2. LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway. Xue Q, et al. Can Respir J, 2021. PMID 34912481, Free PMC Article
  3. Endometrial stromal cell proteomic analysis reveals LIM and SH3 protein 1 (LASP1) plays important roles in the progression of adenomyosis. Liu F, et al. Mol Hum Reprod, 2021 Feb 27. PMID 33543750
  4. Long non-coding RNA LINC01207 promotes prostate cancer progression by downregulating microRNA-1972 and upregulating LIM and SH3 protein 1. Wang S, et al. IUBMB Life, 2020 Sep. PMID 32726517
  5. LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion. Yan P, et al. Oncogene, 2020 Aug. PMID 32704133

See all (186) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to facilitate breast cancer progression by upregulating LIM and SH3 protein 1.
    Title: Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to facilitate breast cancer progression by upregulating LIM and SH3 protein 1.
  2. Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis.
    Title: Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis.
  3. TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs.
    Title: TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs.
  4. LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway.
    Title: LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway.
  5. Circ_0001535 Facilitates Tumor Malignant Progression by miR-485-5p/LASP1 Axis in Colorectal Cancer
    Title: Circ_0001535 Facilitates Tumor Malignant Progression by miR-485-5p/LASP1 Axis in Colorectal Cancer.
  6. CERS6-AS1 Facilitates Oncogenesis and Restrains Ferroptosis in Papillary Thyroid Carcinoma by Serving as a ceRNA through miR-497-5p/LASP1 Axis.
    Title: CERS6-AS1 Facilitates Oncogenesis and Restrains Ferroptosis in Papillary Thyroid Carcinoma by Serving as a ceRNA through miR-497-5p/LASP1 Axis.
  7. Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma.
    Title: Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma.
  8. LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas.
    Title: LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas.
  9. Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis.
    Title: Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis.
  10. Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis.
    Title: Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis.
Submit: New GeneRIF Correction See all GeneRIFs (104)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cortical actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LIM and SH3 domain protein 1
Names
metastatic lymph node gene 50 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271608.2 → NP_001258537.1  LIM and SH3 domain protein 1 isoform b

    See identical proteins and their annotated locations for NP_001258537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at an alternate AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which results in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK294704, AK295522, AK309933, BC007560, BQ961916, X82456
    Consensus CDS
    CCDS62164.1
    UniProtKB/Swiss-Prot
    Q14847
    UniProtKB/TrEMBL
    B4DIC4
    Related
    ENSP00000401048.2, ENST00000433206.6
    Conserved Domains (2) summary
    smart00227
    Location:42 → 72
    NEBU; The Nebulin repeat is present also in Las1
    cd11934
    Location:147 → 205
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

  2. NM_006148.4 → NP_006139.1  LIM and SH3 domain protein 1 isoform a

    See identical proteins and their annotated locations for NP_006139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC007560, DC333179, X82456
    Consensus CDS
    CCDS11331.1
    UniProtKB/Swiss-Prot
    B4DGQ0, Q14847, Q96ED2, Q96IG0
    UniProtKB/TrEMBL
    A8K1D2
    Related
    ENSP00000325240.6, ENST00000318008.11
    Conserved Domains (3) summary
    smart00227
    Location:98 → 128
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11934
    Location:203 → 261
    SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RNA

  1. NR_073384.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the longest open reading frame is in a different frame compared to variant 1, and there is no support for the predicted protein encoded by this ORF.
    Source sequence(s)
    AK095958, AK309933, BC007560, DC333179, X82456

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38870058..38921770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435965.1 → XP_047291921.1  LIM and SH3 domain protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39733108..39784846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14847.2 GenPept UniProtKB/Swiss-Prot:Q14847

Gene LinkOut

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