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GLOD5 glyoxalase domain containing 5 [ Homo sapiens (human) ]

Gene ID: 392465, updated on 5-Mar-2024

Summary

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Official Symbol
GLOD5provided by HGNC
Official Full Name
glyoxalase domain containing 5provided by HGNC
Primary source
HGNC:HGNC:33358
See related
Ensembl:ENSG00000171433 MIM:301112; AllianceGenome:HGNC:33358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with a glyoxalase domain. [provided by RefSeq, Sep 2011]
Expression
Biased expression in duodenum (RPKM 3.2), small intestine (RPKM 2.9) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
Xp11.23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (48761747..48773648)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (48172222..48184150)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48620151..48632064)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29608 Neighboring gene SUV39H1 histone lysine methyltransferase Neighboring gene Sharpr-MPRA regulatory region 10462 Neighboring gene RNA, U6 small nuclear 1056, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29611 Neighboring gene CRISPRi-FlowFISH-validated GATA1 regulatory element 1 Neighboring gene Sharpr-MPRA regulatory region 5097 Neighboring gene ACAA2 pseudogene 1 Neighboring gene RNA, U6 small nuclear 29, pseudogene Neighboring gene CRISPRi-validated e-GATA1 enhancer Neighboring gene CRISPRi-FlowFISH-validated GATA1, HDAC6 and PLP2 regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated HDAC6, PLP2 and PQBP1 regulatory element Neighboring gene CRISPRi-FlowFISH-validated PLP2 regulatory element 5 Neighboring gene CRISPRi-FlowFISH-validated PLP2 regulatory element 6 Neighboring gene CRISPRi-FlowFISH-validated PQBP1 regulatory element 1 Neighboring gene GATA binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article
  2. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
glyoxalase domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021291.2 RefSeqGene

    Range
    5002..16903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080489.3 → NP_001073958.2  glyoxalase domain-containing protein 5

    See identical proteins and their annotated locations for NP_001073958.2

    Status: REVIEWED

    Source sequence(s)
    AC231533, AI458936, BC067236, DY655159
    Consensus CDS
    CCDS55410.1
    UniProtKB/Swiss-Prot
    A6NK44
    Related
    ENSP00000302552.6, ENST00000303227.11
    Conserved Domains (1) summary
    cd07253
    Location:35 → 157
    GLOD5; Human glyoxalase domain-containing protein 5 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    48761747..48773648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    48172222..48184150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NK44.3 GenPept UniProtKB/Swiss-Prot:A6NK44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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