U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LAMC1 laminin subunit gamma 1 [ Homo sapiens (human) ]

Gene ID: 3915, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
LAMC1provided by HGNC
Official Full Name
laminin subunit gamma 1provided by HGNC
Primary source
HGNC:HGNC:6492
See related
Ensembl:ENSG00000135862 MIM:150290; AllianceGenome:HGNC:6492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAMB2
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
Expression
Broad expression in placenta (RPKM 116.1), fat (RPKM 63.0) and 19 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LAMC1 in Genome Data Viewer
Location:
1q25.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (183023420..183145592)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (182382573..182504736)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182992555..183114727)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8189 Neighboring gene keratin 18 pseudogene 28 Neighboring gene RNA, U6 small nuclear 41, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182990015-182990514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:182991252-182991807 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:182991808-182992362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:182992918-182993471 Neighboring gene MPRA-validated peak499 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2209 Neighboring gene Sharpr-MPRA regulatory region 7713 Neighboring gene LAMC1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:183128249-183128750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2211 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:183154769-183155968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2212 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:183197656-183197861 Neighboring gene Sharpr-MPRA regulatory region 7016 Neighboring gene laminin subunit gamma 2 Neighboring gene Sharpr-MPRA regulatory region 596 Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene RPS3A pseudogene 8

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis. Fang Y, et al. Int J Biol Sci, 2022. PMID 35541892, Free PMC Article
  2. A Serological Biomarker of Laminin Gamma 1 Chain Degradation Reflects Altered Basement Membrane Remodeling in Crohn's Disease and DSS Colitis. Lindholm M, et al. Dig Dis Sci, 2022 Aug. PMID 34561759
  3. LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3. Fang L, et al. Mol Oncol, 2021 Nov. PMID 34218518, Free PMC Article
  4. LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies. Han ZR, et al. Neoplasma, 2021 Jul. PMID 33884884
  5. Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population. Chen J, et al. Hereditas, 2020 Jul 7. PMID 32635941, Free PMC Article

See all (177) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis.
    Title: Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis.
  2. NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1.
    Title: NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1.
  3. Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis.
    Title: Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis.
  4. Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
    Title: Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
  5. Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.
    Title: Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.
  6. A Serological Biomarker of Laminin Gamma 1 Chain Degradation Reflects Altered Basement Membrane Remodeling in Crohn's Disease and DSS Colitis.
    Title: A Serological Biomarker of Laminin Gamma 1 Chain Degradation Reflects Altered Basement Membrane Remodeling in Crohn's Disease and DSS Colitis.
  7. LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
    Title: LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
  8. LAMC1 upregulation via TGFbeta induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-kappaB-CXCL1-STAT3.
    Title: LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3.
  9. Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B.
    Title: Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B.
  10. A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study.
    Title: A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC87297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix constituent conferring elasticity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables extracellular matrix structural constituent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoderm development TAS
Traceable Author Statement
more info
 PubMed 
involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemidesmosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of muscle cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of basement membrane organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane NAS
Non-traceable Author Statement
more info
 PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space NAS
Non-traceable Author Statement
more info
 PubMed 
part_of laminin-1 complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of laminin-1 complex TAS
Traceable Author Statement
more info
 PubMed 
part_of laminin-10 complex TAS
Traceable Author Statement
more info
 PubMed 
part_of laminin-11 complex TAS
Traceable Author Statement
more info
 PubMed 
part_of protein complex involved in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
laminin subunit gamma-1
Names
S-LAM gamma
S-laminin subunit gamma
laminin B2 chain
laminin, gamma 1 (formerly LAMB2)
laminin-10 subunit gamma
laminin-11 subunit gamma
laminin-2 subunit gamma
laminin-3 subunit gamma
laminin-4 subunit gamma
laminin-6 subunit gamma
laminin-7 subunit gamma
laminin-8 subunit gamma
laminin-9 subunit gamma

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011463.1 RefSeqGene

    Range
    4961..127133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002293.4 → NP_002284.3  laminin subunit gamma-1 precursor

    See identical proteins and their annotated locations for NP_002284.3

    Status: REVIEWED

    Source sequence(s)
    AL354953, AL450304, BC067813, BF507385, BI768612, CF125114, CN388644, DA401791, J03202
    Consensus CDS
    CCDS1351.1
    UniProtKB/Swiss-Prot
    P11047, Q5VYE7
    Related
    ENSP00000258341.3, ENST00000258341.5
    Conserved Domains (11) summary
    cl14654
    Location:1180 → 1336
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00397
    Location:1072 → 1155
    t_SNARE; Helical region found in SNAREs
    smart00136
    Location:44 → 284
    LamNT; Laminin N-terminal domain (domain VI)
    smart00180
    Location:935 → 980
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:553 → 678
    LamB; Laminin B domain
    smart00283
    Location:1091 → 1302
    MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
    cd00055
    Location:724 → 771
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:445 → 492
    Laminin_EGF; Laminin EGF domain
    pfam05276
    Location:1361 → 1592
    SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    pfam06008
    Location:1287 → 1530
    Laminin_I; Laminin Domain I
    cl23763
    Location:1123 → 1255
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    183023420..183145592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    182382573..182504736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11047.3 GenPept UniProtKB/Swiss-Prot:P11047

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous