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ZNF805 zinc finger protein 805 [ Homo sapiens (human) ]

Gene ID: 390980, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF805provided by HGNC
Official Full Name
zinc finger protein 805provided by HGNC
Primary source
HGNC:HGNC:23272
See related
Ensembl:ENSG00000204524 AllianceGenome:HGNC:23272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 2.1), spleen (RPKM 1.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57240632..57262728)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60337173..60359201)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57752000..57774096)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15125 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11072 Neighboring gene zinc finger protein 264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11073 Neighboring gene aurora kinase C Neighboring gene Sharpr-MPRA regulatory region 2652 Neighboring gene NANOG hESC enhancer GRCh37_chr19:57774577-57775110 Neighboring gene ZNF460 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11074 Neighboring gene Sharpr-MPRA regulatory region 5355 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:57791112-57792311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15130 Neighboring gene zinc finger protein 460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57814007-57814506 Neighboring gene PPPDE peptidase domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Lasky-Su J, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18821565
  2. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, et al. Oncogene, 2019 Apr. PMID 30575818, Free PMC Article
  3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  5. TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells. Chen Y, et al. Biochem Biophys Res Commun, 2022 Oct 15. PMID 35944360

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686P08106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 805
Names
CTC-444N24.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001023563.4 → NP_001018857.2  zinc finger protein 805 isoform 1

    See identical proteins and their annotated locations for NP_001018857.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC005261
    Consensus CDS
    CCDS46207.1
    UniProtKB/Swiss-Prot
    B4DNM5, Q5CZA5
    Related
    ENSP00000412999.1, ENST00000414468.3
    Conserved Domains (6) summary
    smart00349
    Location:13 → 73
    KRAB; krueppel associated box
    COG5048
    Location:192 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485 → 505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:399 → 421
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:13 → 52
    KRAB; KRAB box
    pfam13465
    Location:413 → 438
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001145078.2 → NP_001138550.1  zinc finger protein 805 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC005261, AK297977
    Consensus CDS
    CCDS46208.1
    UniProtKB/Swiss-Prot
    Q5CZA5
    Related
    ENSP00000365414.2, ENST00000354309.4
    Conserved Domains (3) summary
    COG5048
    Location:59 → 435
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:280 → 305
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57240632..57262728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60337173..60359201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5CZA5.3 GenPept UniProtKB/Swiss-Prot:Q5CZA5

Gene LinkOut

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