LAMA3 laminin subunit alpha 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LAMA3provided by HGNC
Official Full Name: laminin subunit alpha 3provided by HGNC
Primary source: HGNC:HGNC:6483
See related: Ensembl:ENSG00000053747 MIM:600805; AllianceGenome:HGNC:6483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: E170; LOCS; BM600; JEB2A; JEB2B; JEB2C; LAMNA
Summary: The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression: Broad expression in lung (RPKM 10.8), stomach (RPKM 10.0) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 18q11.2

Exon count:: 79

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (23689453..23955066)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (23883722..24149324)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (21269417..21535030)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
Title: LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
Title: Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
Title: LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
Title: Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
Gene expression profiling of laminin alpha3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
Title: Gene expression profiling of laminin α3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
Title: High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
Title: LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma.
Title: Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma.
Laminin332 mediates proliferation, apoptosis, invasion, migration and epithelialtomesenchymal transition in pancreatic ductal adenocarcinoma.
Title: Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma.
The authors describe the natural history of JEB in three children with the same LAMA3 splice-site mutation. In spite of residual laminin 332, two of them died prematurely.
Title: Natural history and clinical outcome of junctional epidermolysis bullosa generalized intermediate due to a LAMA3 mutation.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Epidermolysis bullosa, junctional 2A, intermediate MedGen: C5676936 OMIM: 619783 GeneReviews: Not available	Compare labs
Epidermolysis bullosa, junctional 2B, severe MedGen: C5676937 OMIM: 619784 GeneReviews: Not available	Compare labs
Junctional epidermolysis bullosa gravis of Herlitz MedGen: C0079683 OMIM: 226700 GeneReviews: Junctional Epidermolysis Bullosa	Compare labs
Laryngo-onycho-cutaneous syndrome MedGen: C1328355 OMIM: 245660 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. EBI GWAS Catalog EBI GWAS CatalogPubMed
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins	PubMed
Tat	tat	Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution	PubMed
	tat	HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1	PubMed
	tat	HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

PMC138037P1 (e-PCR)
- UniSTS:270861

D8S2279 (e-PCR)
- UniSTS:473907

sY3084 (e-PCR)
- UniSTS:515126

D18S1260 (e-PCR)
- UniSTS:72519

STS-D29067 (e-PCR)
- UniSTS:5741

SHGC-145215 (e-PCR)
- UniSTS:174449

SHGC-155337 (e-PCR)
- UniSTS:183168

SHGC-83562 (e-PCR)
- UniSTS:101764

SHGC-156081 (e-PCR)
- UniSTS:183175

PMC113197P1 (e-PCR)
- UniSTS:270249

WI-9358 (e-PCR)
- UniSTS:77751

G18025 (e-PCR)
- UniSTS:49093

A009G17 (e-PCR)
- UniSTS:28617

G42069 (e-PCR)
- UniSTS:93130

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed
involved_in hemidesmosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in basement membrane	TAS Traceable Author Statement more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in hemidesmosome	IEA Inferred from Electronic Annotation more info
part_of laminin-3 complex	IEA Inferred from Electronic Annotation more info
part_of laminin-5 complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: laminin subunit alpha-3

Names: BM600 150kD subunit; LAM3, alpha-3 subunit; epiligrin 170 kda subunit; epiligrin alpha 3 subunit; kalinin 165kD subunit; kalinin subunit alpha; laminin 5, alpha-3 subunit; laminin A3; laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin); laminin-5 alpha 3 chain; laminin-5 subunit alpha; laminin-6 subunit alpha; laminin-7 subunit alpha; nicein 150kD subunit; nicein subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007853.2 RefSeqGene

Range

4856..270469

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000227.6 → NP_000218.3 laminin subunit alpha-3 isoform 2 precursor

See identical proteins and their annotated locations for NP_000218.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a distinct 5' UTR, lacks exons in the 5' coding region, and uses an alternate start codon compared to variant 1. The encoded isoform (2, also known as alpha3a) has a distinct and shorter N-terminus than isoform 1. Variants 2 and 4 encode "a" isoforms.

Source sequence(s)

AA001432, AC010754, AY327115, DA862923, KF456351, L34155

Consensus CDS

CCDS11880.1

UniProtKB/TrEMBL

A0A0A6YYF2, Q59HA6

Related

ENSP00000269217.5, ENST00000269217.11

Conserved Domains (7) summary

COG0840
Location:399 → 779

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:77 → 123

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1549 → 1700

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:125 → 175

Laminin_EGF; Laminin EGF domain

pfam06008
Location:236 → 495

Laminin_I; Laminin Domain I

pfam06009
Location:679 → 807

Laminin_II; Laminin Domain II

cl21509
Location:483 → 647

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001127717.4 → NP_001121189.2 laminin subunit alpha-3 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3, also called b2) lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform 3 (also known as alpha3b2), which is shorter than isoform 1. Variants 1 and 3 encode "b" isoforms.

Source sequence(s)

AA001432, AC010754, AK096422, AY327116, KF456351

Consensus CDS

CCDS45838.1

UniProtKB/TrEMBL

A0A0A0MSA0, B0YJ32

Related

ENSP00000382432.2, ENST00000399516.7

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1514 → 1641

LamB; Laminin B domain

smart00282
Location:2379 → 2514

LamG; Laminin G domain

cd00055
Location:535 → 577

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3102 → 3253

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1266 → 1314

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1845 → 2048

Laminin_I; Laminin Domain I

pfam06009
Location:2232 → 2360

Laminin_II; Laminin Domain II

cl21509
Location:2036 → 2200

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001127718.4 → NP_001121190.2 laminin subunit alpha-3 isoform 4 precursor

See identical proteins and their annotated locations for NP_001121190.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) has a distinct 5' UTR, lacks exons in the 5' coding region, lacks an internal in-frame exon, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 4 encode "a" isoforms.

Source sequence(s)

AA001432, AC010754, AY327114, DA862923, KF456351

Consensus CDS

CCDS59307.1

UniProtKB/TrEMBL

A0A0A0MTS5, Q59HA6

Related

ENSP00000466557.1, ENST00000587184.5

Conserved Domains (6) summary

cd00055
Location:77 → 123

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1493 → 1644

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:125 → 175

Laminin_EGF; Laminin EGF domain

pfam06008
Location:236 → 439

Laminin_I; Laminin Domain I

pfam06009
Location:623 → 751

Laminin_II; Laminin Domain II

cl21509
Location:427 → 591

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001302996.2 → NP_001289925.1 laminin subunit alpha-3 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as LN1) lacks a large portion of the 3' coding region and has a distinct 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5, also known as LaNt alpha31) has a distinct and shorter C-terminus than isoform 1. This variant is supported by experimental data in PMID:19773554.

Source sequence(s)

AC067796, AI125611, AK096422, AY327115

UniProtKB/Swiss-Prot

Q16787

Conserved Domains (3) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:299 → 344

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:356 → 423

Laminin_EGF; Laminin EGF domain
NM_198129.4 → NP_937762.2 laminin subunit alpha-3 isoform 1 precursor

See identical proteins and their annotated locations for NP_937762.2

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as b1, represents the longest transcript and encodes the longest isoform (1, also known as alpha3B1). Variants 1 and 3 encode "b" isoforms.

Source sequence(s)

AB107369, AC010754, AC067796

Consensus CDS

CCDS42419.1

UniProtKB/Swiss-Prot

B0YJ33, Q13679, Q13680, Q16787, Q6VU67, Q6VU68, Q6VU69, Q76E14, Q96TG0

UniProtKB/TrEMBL

B0YJ32

Related

ENSP00000324532.8, ENST00000313654.14

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1514 → 1641

LamB; Laminin B domain

smart00282
Location:2435 → 2570

LamG; Laminin G domain

cd00055
Location:535 → 577

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3158 → 3309

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1266 → 1314

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1845 → 2104

Laminin_I; Laminin Domain I

pfam06009
Location:2288 → 2416

Laminin_II; Laminin Domain II

cl21509
Location:2092 → 2256

ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

NR_130106.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks multiple 3' exons and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon results in an open reading frame without a stop codon and renders the transcript a candidate for non-stop decay.

Source sequence(s)

AK096422, BC033663, BC093406

Related

ENST00000585600.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000018.10 Reference GRCh38.p14 Primary Assembly

Range

23689453..23955066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525978.3 → XP_011524280.1 laminin subunit alpha-3 isoform X1

UniProtKB/TrEMBL

B0YJ32

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1523 → 1650

LamB; Laminin B domain

smart00282
Location:2444 → 2579

LamG; Laminin G domain

cd00055
Location:535 → 577

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3167 → 3318

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1275 → 1323

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1854 → 2113

Laminin_I; Laminin Domain I

pfam06009
Location:2297 → 2425

Laminin_II; Laminin Domain II

cl21509
Location:2101 → 2265

ApoLp-III_like; Apolipophorin-III and similar insect proteins
XM_011525982.3 → XP_011524284.1 laminin subunit alpha-3 isoform X8

UniProtKB/TrEMBL

B0YJ32

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1523 → 1650

LamB; Laminin B domain

smart00282
Location:2345 → 2480

LamG; Laminin G domain

cd00055
Location:535 → 577

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3068 → 3219

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1275 → 1323

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1854 → 2113

Laminin_I; Laminin Domain I

pfam06009
Location:2217 → 2326

Laminin_II; Laminin Domain II

cl21509
Location:2066 → 2196

ApoLp-III_like; Apolipophorin-III and similar insect proteins
XM_011525980.3 → XP_011524282.1 laminin subunit alpha-3 isoform X3

UniProtKB/TrEMBL

B0YJ32

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1517 → 1644

LamB; Laminin B domain

smart00282
Location:2438 → 2573

LamG; Laminin G domain

cd00055
Location:535 → 577

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3161 → 3312

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1269 → 1317

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1848 → 2107

Laminin_I; Laminin Domain I

pfam06009
Location:2291 → 2419

Laminin_II; Laminin Domain II

cl21509
Location:2095 → 2259

ApoLp-III_like; Apolipophorin-III and similar insect proteins
XM_011525979.3 → XP_011524281.1 laminin subunit alpha-3 isoform X2

UniProtKB/TrEMBL

B0YJ32

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1520 → 1647

LamB; Laminin B domain

smart00282
Location:2441 → 2576

LamG; Laminin G domain

cd00055
Location:535 → 577

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3164 → 3315

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1272 → 1320

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1851 → 2110

Laminin_I; Laminin Domain I

pfam06009
Location:2294 → 2422

Laminin_II; Laminin Domain II

cl21509
Location:2098 → 2262

ApoLp-III_like; Apolipophorin-III and similar insect proteins
XM_047437506.1 → XP_047293462.1 laminin subunit alpha-3 isoform X9
XM_011525981.3 → XP_011524283.1 laminin subunit alpha-3 isoform X4

UniProtKB/TrEMBL

B0YJ32

Conserved Domains (9) summary

smart00136
Location:46 → 297

LamNT; Laminin N-terminal domain (domain VI)

smart00281
Location:1479 → 1606

LamB; Laminin B domain

smart00282
Location:2400 → 2535

LamG; Laminin G domain

cd00055
Location:491 → 533

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3123 → 3274

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1231 → 1279

Laminin_EGF; Laminin EGF domain

pfam06008
Location:1810 → 2069

Laminin_I; Laminin Domain I

pfam06009
Location:2253 → 2381

Laminin_II; Laminin Domain II

cl21509
Location:2057 → 2221

ApoLp-III_like; Apolipophorin-III and similar insect proteins
XM_047437503.1 → XP_047293459.1 laminin subunit alpha-3 isoform X5
XM_047437504.1 → XP_047293460.1 laminin subunit alpha-3 isoform X6
XM_047437505.1 → XP_047293461.1 laminin subunit alpha-3 isoform X7
XM_017025743.1 → XP_016881232.1 laminin subunit alpha-3 isoform X10

UniProtKB/TrEMBL

A0A3B3ITG1

Related

ENSP00000497885.1, ENST00000649721.1
XM_017025744.2 → XP_016881233.1 laminin subunit alpha-3 isoform X11