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LAG3 lymphocyte activating 3 [ Homo sapiens (human) ]

Gene ID: 3902, updated on 7-Apr-2024

Summary

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Official Symbol
LAG3provided by HGNC
Official Full Name
lymphocyte activating 3provided by HGNC
Primary source
HGNC:HGNC:6476
See related
Ensembl:ENSG00000089692 MIM:153337; AllianceGenome:HGNC:6476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD223
Summary
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 15.1), lymph node (RPKM 8.3) and 12 other tissues See more
Orthologs
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Genomic context

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See LAG3 in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6772520..6778455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6782086..6788021)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6881686..6887621)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5880 Neighboring gene myeloid leukemia factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4182 Neighboring gene parathymosin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6887480-6888130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6888131-6888782 Neighboring gene Sharpr-MPRA regulatory region 1171 Neighboring gene RNA, 7SL, cytoplasmic 380, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6898178-6898735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5883 Neighboring gene CD4 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928026-6928526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6928527-6929027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis. Pedersen JM, et al. Arthritis Res Ther, 2023 Jun 7. PMID 37287025, Free PMC Article
  2. Lymphocyte-activation gene 3 protein expression in tumor-infiltrating lymphocytes is associated with a poor prognosis of ovarian clear cell carcinoma. Zaitsu S, et al. J Ovarian Res, 2023 May 13. PMID 37179337, Free PMC Article
  3. LAG-3 transcriptomic expression patterns across malignancies: Implications for precision immunotherapeutics. Adashek JJ, et al. Cancer Med, 2023 Jun. PMID 37132280, Free PMC Article
  4. The elevated expression of LAG-3 on CD8+T cells correlates with disease severity of pulmonary TB. Chen J, et al. Microb Pathog, 2023 Jun. PMID 37004963
  5. LAG-3 expression in tumor microenvironment of triple-negative breast cancer. Tahtacı G, et al. Turk J Med Sci, 2023 Feb. PMID 36945923, Free PMC Article

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of lymphocyte activation gene-3 on CD4[+]T cells is regulated by cytokine interleukin-18 in myasthenia gravis.
    Title: Expression of lymphocyte activation gene-3 on CD4(+)T cells is regulated by cytokine interleukin-18 in myasthenia gravis.
  2. Altered immune co-inhibitory receptor expression and correlation of LAG-3 expression to disease severity in NMOSD.
    Title: Altered immune co-inhibitory receptor expression and correlation of LAG-3 expression to disease severity in NMOSD.
  3. LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma.
    Title: LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma.
  4. ATM-AMPKalpha mediated LAG-3 expression suppresses T cell function in prostate cancer.
    Title: ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer.
  5. Characterisation of the protein expression of the emerging immunotherapy targets VISTA, LAG-3 and PRAME in primary uveal melanoma: insights from a southern French patient cohort.
    Title: Characterisation of the protein expression of the emerging immunotherapy targets VISTA, LAG-3 and PRAME in primary uveal melanoma: insights from a southern French patient cohort.
  6. Comprehensive immunophenotyping of solid tumor-infiltrating immune cells reveals the expression characteristics of LAG-3 and its ligands.
    Title: Comprehensive immunophenotyping of solid tumor-infiltrating immune cells reveals the expression characteristics of LAG-3 and its ligands.
  7. Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells.
    Title: Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells.
  8. The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif.
    Title: The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif.
  9. A unique expression pattern of LAG3 distinct from that of other immune checkpoints in diffuse large B-cell lymphoma.
    Title: A unique expression pattern of LAG3 distinct from that of other immune checkpoints in diffuse large B-cell lymphoma.
  10. LAG3 in gastric cancer: it's complicated.
    Title: LAG3 in gastric cancer: it's complicated.
Submit: New GeneRIF Correction See all GeneRIFs (133)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class II protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables antigen binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of regulatory T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasmacytoid dendritic cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
lymphocyte activation gene 3 protein
Names
lymphocyte-activation gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414176.1 → NP_001401105.1  lymphocyte activation gene 3 protein isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC125494

  2. NM_001414177.1 → NP_001401106.1  lymphocyte activation gene 3 protein isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC125494

  3. NM_002286.6 → NP_002277.4  lymphocyte activation gene 3 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_002277.4

    Status: REVIEWED

    Source sequence(s)
    AA687676, AC125494, AI274900, X51985
    Consensus CDS
    CCDS8561.1
    UniProtKB/Swiss-Prot
    A8K7T9, P18627, Q7Z643
    Related
    ENSP00000203629.2, ENST00000203629.3
    Conserved Domains (3) summary
    smart00410
    Location:267 → 348
    IG_like; Immunoglobulin like
    pfam13895
    Location:174 → 259
    Ig_2; Immunoglobulin domain
    cl11960
    Location:263 → 336
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6772520..6778455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6782086..6788021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18627.5 GenPept UniProtKB/Swiss-Prot:P18627

Gene LinkOut

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