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INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 388324, updated on 5-Mar-2024

Summary

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Official Symbol
INCA1provided by HGNC
Official Full Name
inhibitor of CDK, cyclin A1 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:32224
See related
Ensembl:ENSG00000196388 MIM:617374; AllianceGenome:HGNC:32224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD45
Summary
Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 10.5), prostate (RPKM 1.7) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
17p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4988130..4997522, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4878461..4887846, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4891425..4900817, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903901 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene microRNA 6865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8059 Neighboring gene CAMTA2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4902950-4903561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4903562-4904172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4906716-4907915 Neighboring gene kinesin family member 1C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8063 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:4923264-4924463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4925730-4926294 Neighboring gene KIF1C antisense RNA 1 Neighboring gene uncharacterized LOC105371501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11564 Neighboring gene solute carrier family 52 member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. Kang S, et al. J Biol Chem, 2005 Nov 11. PMID 16148011
  2. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. Li XB, et al. Mol Med Rep, 2011 Nov-Dec. PMID 21874239
  3. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). Chen X, et al. Biochem Cell Biol, 2008 Aug. PMID 18756329
  4. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, et al. Int J Cancer, 2005 Aug 20. PMID 15800920
  5. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. Bäumer N, et al. J Biol Chem, 2011 Aug 12. PMID 21540187, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling
    Title: Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.
  2. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.
    Title: The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC148150, MGC148151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein INCA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167985.2 → NP_001161457.1  protein INCA1 isoform 2

    See identical proteins and their annotated locations for NP_001161457.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AY601907, AY604176
    Consensus CDS
    CCDS11064.1
    UniProtKB/Swiss-Prot
    Q0VD86
    Related
    ENSP00000461844.1, ENST00000575780.5
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 175
    INCA1

  2. NM_001167986.2 → NP_001161458.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001161458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AY601906, AY604176, BC119781
    Consensus CDS
    CCDS54074.1
    UniProtKB/Swiss-Prot
    Q0VD86, Q6J273, Q6PKN9
    Related
    ENSP00000458316.1, ENST00000574617.1
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 190
    INCA1

  3. NM_001167987.2 → NP_001161459.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001161459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AY601906, AY604176, BC122873
    Consensus CDS
    CCDS54074.1
    UniProtKB/Swiss-Prot
    Q0VD86, Q6J273, Q6PKN9
    Related
    ENSP00000460673.1, ENST00000576820.5
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 190
    INCA1

  4. NM_001394788.1 → NP_001381717.1  protein INCA1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS54074.1
    UniProtKB/Swiss-Prot
    Q0VD86, Q6J273, Q6PKN9
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 190
    INCA1

  5. NM_001394789.1 → NP_001381718.1  protein INCA1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS54074.1
    UniProtKB/Swiss-Prot
    Q0VD86, Q6J273, Q6PKN9
    Related
    ENSP00000511805.1, ENST00000695324.1
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 190
    INCA1

  6. NM_001394790.1 → NP_001381719.1  protein INCA1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11064.1
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 175
    INCA1

  7. NM_001394791.1 → NP_001381720.1  protein INCA1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11064.1
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 175
    INCA1

  8. NM_213726.3 → NP_998891.2  protein INCA1 isoform 2

    See identical proteins and their annotated locations for NP_998891.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AY601906, AY604176
    Consensus CDS
    CCDS11064.1
    UniProtKB/Swiss-Prot
    Q0VD86
    Related
    ENSP00000347129.3, ENST00000355025.7
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 175
    INCA1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4988130..4997522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256628.6 → XP_005256685.1  protein INCA1 isoform X1

    See identical proteins and their annotated locations for XP_005256685.1

    UniProtKB/Swiss-Prot
    Q0VD86, Q6J273, Q6PKN9
    Conserved Domains (1) summary
    pfam15142
    Location:12 → 190
    INCA1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4878461..4887846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316026.1 → XP_054172001.1  protein INCA1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VD86.1 GenPept UniProtKB/Swiss-Prot:Q0VD86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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