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SLC22A10 solute carrier family 22 member 10 [ Homo sapiens (human) ]

Gene ID: 387775, updated on 3-Apr-2024

Summary

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Official Symbol
SLC22A10provided by HGNC
Official Full Name
solute carrier family 22 member 10provided by HGNC
Primary source
HGNC:HGNC:18057
See related
Ensembl:ENSG00000184999 MIM:607580; AllianceGenome:HGNC:18057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT5; hOAT5
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver (RPKM 17.4) See more
Orthologs
all
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Genomic context

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Location:
11q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63289903..63363144)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63279174..63301052)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63057375..63079255)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 25 Neighboring gene uncharacterized LOC105369334 Neighboring gene cyclin D2 pseudogene 1 Neighboring gene solute carrier family 22 member 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63202489-63203041 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63203042-63203593 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63215327-63216263 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63216264-63217199 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63219920-63220481 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63220482-63221042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63227984-63228595 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene phospholipase A and acyltransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. Eraly SA, et al. Biochem Biophys Res Commun, 2002 Oct 11. PMID 12372408
  2. Isolation of a family of organic anion transporters from human liver and kidney. Sun W, et al. Biochem Biophys Res Commun, 2001 May 4. PMID 11327718
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
  5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 10
Names
organic anion transporter 5
solute carrier family 22 (organic anion/cation transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039752.4 → NP_001034841.3  solute carrier family 22 member 10

    See identical proteins and their annotated locations for NP_001034841.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AB075876, AP001880, BK001421, BX091233, CB162810, DR003989
    Consensus CDS
    CCDS41661.1
    UniProtKB/Swiss-Prot
    Q63ZE4, Q68CJ0
    Related
    ENSP00000327569.6, ENST00000332793.11
    Conserved Domains (2) summary
    cd06174
    Location:143 → 516
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 526
    2A0119; cation transport protein

RNA

  1. NR_134874.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' end and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB075876, AK298430, AP001880, CB162810

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63289903..63363144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426920.1 → XP_047282876.1  solute carrier family 22 member 10 isoform X1

  2. XM_047426924.1 → XP_047282880.1  solute carrier family 22 member 10 isoform X6

  3. XM_047426921.1 → XP_047282877.1  solute carrier family 22 member 10 isoform X3

  4. XM_017017699.2 → XP_016873188.1  solute carrier family 22 member 10 isoform X2

  5. XM_047426922.1 → XP_047282878.1  solute carrier family 22 member 10 isoform X4

    Related
    ENSP00000433048.1, ENST00000533483.5

  6. XM_047426925.1 → XP_047282881.1  solute carrier family 22 member 10 isoform X7

  7. XM_047426923.1 → XP_047282879.1  solute carrier family 22 member 10 isoform X5

RNA

  1. XR_007062480.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63279174..63301052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63ZE4.2 GenPept UniProtKB/Swiss-Prot:Q63ZE4

Gene LinkOut

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